INT92684

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.79
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col3a1) extracellular region (Col3a1) proteinaceous extracellular matrix (Col3a1)
Anatomy Link Frequency
uterus 3
PSC 1
extracellular matrix 1
Col3a1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 59 99.82 Very High Very High Very High
Chronic pancreatitis 1 65.84 Quite High
Inflammation 19 61.72 Quite High
cytokine 24 37.68 Quite Low
metalloproteinase 36 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 3 100.00 Very High Very High Very High
Fibrosis 48 99.82 Very High Very High Very High
Pulmonary Fibrosis 29 99.50 Very High Very High Very High
Targeted Disruption 4 75.00 Quite High
Cancer 4 74.48 Quite High
Necrosis 3 73.92 Quite High
Pancreatitis 1 65.84 Quite High
INFLAMMATION 16 61.72 Quite High
Adhesions 3 59.12 Quite High
Apoptosis 5 49.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the microarray data showed consistent, reproducible upregulation of COL3A1, BGN, SPARC and NID1 in IL11Ra-/- compared to wild type uterus, this effect was not statistically significant when real-time RT-PCR was used as an alternative quantitation method.
Positive_regulation (upregulation) of COL3A1 in uterus
1) Confidence 0.56 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.06 Pain Relevance 0
Together with data from this study showing increased COL3A1 mRNA and mature collagen III protein in IL11Ra-/- uterus at 48 h of decidualization, it appears that successful decidualization involves downregulation of COL3A1 transcription.
Positive_regulation (increased) of COL3A1 in uterus
2) Confidence 0.40 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.15 Pain Relevance 0
The ECM genes COL3A1, SPARC, BGN and NID1 were among those upregulated in IL11Ra-/- uterus compared to wild type.
Positive_regulation (upregulated) of COL3A1 in uterus
3) Confidence 0.37 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
This confirms that TGF-beta1 mediates pancreatic fibrosis through activation of PSC and deposition of collagen type I and III at early time points.
Positive_regulation (activation) of collagen type I and III in PSC associated with fibrosis and primary sclerosing cholangitis
4) Confidence 0.31 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.88 Pain Relevance 0.19
Lung fibrosis is characterized by the accumulation of extracellular matrix proteins, such as collagen III.
Positive_regulation (accumulation) of collagen III in extracellular matrix associated with fibrosis and pulmonary fibrosis
5) Confidence 0.07 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.70 Pain Relevance 0.26

General Comments

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