INT92685

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Context Info
Confidence 0.72
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.92
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) Golgi apparatus (Ctgf) proteinaceous extracellular matrix (Ctgf)
Anatomy Link Frequency
PSC 2
fibroblasts 2
joints 1
connective tissue 1
Ctgf (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 100.00 Very High Very High Very High
Paracetamol 8 98.40 Very High Very High Very High
alcohol 6 91.92 High High
fibrosis 70 88.76 High High
Inflammation 16 85.44 High High
Chronic pancreatitis 4 82.52 Quite High
Inflammatory mediators 2 74.96 Quite High
Osteoarthritis 1 50.00 Quite Low
cytokine 2 43.12 Quite Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 24 99.44 Very High Very High Very High
Stress 3 99.18 Very High Very High Very High
Targeted Disruption 13 92.80 High High
Fibrosis 93 91.44 High High
Injury 3 87.60 High High
INFLAMMATION 23 85.44 High High
Pancreatitis 4 82.52 Quite High
Hepatotoxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show the production of acetaldehyde and oxidant stress in mouse PSC are the cause of increased CCN2 mRNA and protein production after exposure of the cells to ethanol.
Transcription (production) of CCN2 in PSC associated with stress and primary sclerosing cholangitis
1) Confidence 0.72 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.47 Pain Relevance 0.03
In the presence of 4MP, DAS, or the anti-oxidants vitamin D or catalase, there was a substantial decrease in the ability of ethanol to stimulate CCN2 mRNA expression and a concomitant decrease in CCN2-positive PSC.
Transcription (expression) of CCN2 in PSC associated with primary sclerosing cholangitis
2) Confidence 0.72 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.72 Pain Relevance 0.20
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Transcription (Expression) of CTGF in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
3) Confidence 0.59 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.22 Pain Relevance 0.77
CCN2 production, assessed by reverse-transcriptase polymerase chain reaction to measure CCN2 mRNA levels or by fluorescence activated cell sorting to assess CCN2 protein, was enhanced in a dose-dependent manner by ethanol or acetaldehyde.
Transcription (levels) of CCN2
4) Confidence 0.53 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.61 Pain Relevance 0.23
As measured by quantitative real-time RT-PCR, the transcripts of Col1a2, Ctgf and SPARC showed increased expression in the fibroblasts from TBR1CA; Cre-ER mice injected with 4-OHT, in which Tgfbr1 was constitutively active, compared with those in the cells from TBR1CA; Cre-ER mice injected with oil (Figure 1).
Transcription (transcripts) of Ctgf in fibroblasts
5) Confidence 0.51 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0 Pain Relevance 0
In OA joints, the tissue distribution of CTGF was similar to NOC but more intense staining was observed, and in addition some matrix staining was evident that was not present in the negative control sections.
Transcription (distribution) of CTGF in joints
6) Confidence 0.37 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 0 Pain Relevance 0
On day 70, the ECM composition was expanded by increased deposition of fibronectin, whereas connective tissue growth factor, fibroblast growth factor (FGF)-1, and FGF-2 mRNA expression levels were elevated in addition to TGF-beta1.
Transcription (expression) of tissue growth factor in fibroblast
7) Confidence 0.18 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123210 Disease Relevance 0.90 Pain Relevance 0.20

General Comments

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