INT92686

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 51
Total Number 55
Disease Relevance 34.40
Pain Relevance 11.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) Golgi apparatus (Ctgf) proteinaceous extracellular matrix (Ctgf)
Anatomy Link Frequency
connective tissue 12
fibroblasts 7
PSC 6
lungs 3
joints 2
Ctgf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 331 100.00 Very High Very High Very High
chemokine 80 100.00 Very High Very High Very High
metalloproteinase 30 100.00 Very High Very High Very High
Inflammatory mediators 15 99.88 Very High Very High Very High
Paracetamol 37 99.82 Very High Very High Very High
fibrosis 818 99.48 Very High Very High Very High
cytokine 103 99.38 Very High Very High Very High
alcohol 40 99.28 Very High Very High Very High
antagonist 73 98.78 Very High Very High Very High
Chronic pancreatitis 53 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 385 100.00 Very High Very High Very High
Cancer 285 100.00 Very High Very High Very High
Metastasis 230 100.00 Very High Very High Very High
Necrosis 31 100.00 Very High Very High Very High
Stress 14 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 61 99.84 Very High Very High Very High
Infection 82 99.70 Very High Very High Very High
Fibrosis 1180 99.68 Very High Very High Very High
Targeted Disruption 202 99.16 Very High Very High Very High
Alcoholic Pancreatitis 4 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells.
Gene_expression (expression) of CCN2 in stellate cells
1) Confidence 0.77 Published 2009 Journal Growth Factors Section Title Doc Link 19280452 Disease Relevance 0.64 Pain Relevance 0.27
The potential therapeutic effects of inhibitors of ethanol metabolism or anti-oxidants in alcoholic pancreatitis may arise in part through their ability to attenuate CCN2 production by PSC.
Gene_expression (production) of CCN2 in PSC associated with primary sclerosing cholangitis and alcoholic pancreatitis
2) Confidence 0.77 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.53 Pain Relevance 0.03
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Gene_expression (expression) of CTGF associated with paracetamol
3) Confidence 0.75 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.89 Pain Relevance 0.84
We used Ctgf siRNA as a positive control for inhibition of Ctgf and collagen expression.
Gene_expression (expression) of Ctgf
4) Confidence 0.74 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
Recently, while examining SPARC regulatory role on the ECM components in human fibroblasts using linear structure equations, we demonstrated that SPARC positively controlled the expression of CTGF [26].
Gene_expression (expression) of CTGF in fibroblasts
5) Confidence 0.74 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.48 Pain Relevance 0.06
These results appear to contradict our previous report of parallel inhibition of SPARC and CTGF expression in human fibroblasts by SPARC siRNA [14].
Gene_expression (expression) of CTGF in fibroblasts
6) Confidence 0.74 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.38 Pain Relevance 0.09
It should be noted that the Ctgf expression in the fibroblasts was not reduced upon SPARC inhibition.
Gene_expression (expression) of Ctgf in fibroblasts
7) Confidence 0.74 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.26 Pain Relevance 0.03
Seventy-two hours after SPARC siRNA or Ctgf siRNA transfection, significant reductions of SPARC (95%) by SPARC siRNA and Ctgf (64%) by Ctgf siRNA were observed in the fibroblasts (Figure 2A).
Gene_expression (transfection) of Ctgf siRNA in fibroblasts
8) Confidence 0.74 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.07 Pain Relevance 0
Expression of macrophage chemotactic protein-1 (MCP-1), KC/gro, interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9), and connective tissue growth factor (CTGF), inflammatory mediators known to participate in tissue repair, as well as the anti-inflammatory cytokine, interleukin-10 (IL-10), also increased in the liver following acetaminophen administration.
Gene_expression (Expression) of connective tissue growth factor in connective tissue associated with paracetamol, inflammatory mediators, inflammation, metalloproteinase and cytokine
9) Confidence 0.73 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 1.10 Pain Relevance 0.77
The aim of this study was to establish a model of ACP in mice, a species that is usually resistant to the toxic effects of alcohol, and to identify the cell type(s) responsible for production of connective tissue growth factor (CTGF), a pro-fibrotic molecule.
Gene_expression (production) of connective tissue growth factor in connective tissue associated with fibrosis, chronic pancreatitis and alcohol
10) Confidence 0.72 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 0.95 Pain Relevance 0.48
In mice receiving ethanol plus cerulein, there was increased collagen deposition as compared with other treatment groups as well as increased frequency of alpha-smooth muscle actin and desmin-positive PSC, which also showed significantly enhanced CTGF protein production.
Gene_expression (production) of CTGF in PSC associated with primary sclerosing cholangitis
11) Confidence 0.72 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.28 Pain Relevance 0.69
The aim of this study was to establish a model of ACP in mice, a species that is usually resistant to the toxic effects of alcohol, and to identify the cell type(s) responsible for production of connective tissue growth factor (CTGF), a pro-fibrotic molecule.
Gene_expression (production) of CTGF in connective tissue associated with fibrosis, chronic pancreatitis and alcohol
12) Confidence 0.72 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 0.95 Pain Relevance 0.48
Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells.
Gene_expression (expression) of tissue growth factor in stellate cells
13) Confidence 0.68 Published 2009 Journal Growth Factors Section Title Doc Link 19280452 Disease Relevance 0.64 Pain Relevance 0.27
CCN2 production, assessed by reverse-transcriptase polymerase chain reaction to measure CCN2 mRNA levels or by fluorescence activated cell sorting to assess CCN2 protein, was enhanced in a dose-dependent manner by ethanol or acetaldehyde.
Gene_expression (production) of CCN2
14) Confidence 0.68 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.61 Pain Relevance 0.25
In NOS II knockout mice treated with acetaminophen, hepatic expression of TNF-alpha, as well as CTGF, was significantly increased compared to wild-type mice.
Gene_expression (expression) of CTGF associated with targeted disruption and paracetamol
15) Confidence 0.66 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.09 Pain Relevance 0.81
A possible explanation is that over-expressed Ctgf from constitutively activated TGF-?
Gene_expression (expressed) of Ctgf
16) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.45 Pain Relevance 0.13
In conclusion, a mouse model of ACP has been developed that mimics key pathophysiological features of the disease in humans and which shows that activated PSC are the principal producers of collagen and CTGF.
Gene_expression (producers) of CTGF in PSC associated with primary sclerosing cholangitis, disease and chronic pancreatitis
17) Confidence 0.63 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 0.96 Pain Relevance 0.57
Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis.
Gene_expression (production) of Connective tissue growth factor in Connective tissue associated with chronic pancreatitis
18) Confidence 0.63 Published 2010 Journal Lab. Invest. Section Title Doc Link 20368699 Disease Relevance 1.06 Pain Relevance 0.55
In contrast to past alcohol consumption, present alcohol intake appears associated with the expression of immediate response genes to tissue damage, repair and remodeling, inflammatory and stress response (IFITM1, CRHBP, TIMP 2 and 3, DUSP1, CTGF).


Gene_expression (expression) of CTGF associated with stress, inflammation and alcohol
19) Confidence 0.58 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1774576 Disease Relevance 0.79 Pain Relevance 0.26
Expression of macrophage chemotactic protein-1 (MCP-1), KC/gro, interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9), and connective tissue growth factor (CTGF), inflammatory mediators known to participate in tissue repair, as well as the anti-inflammatory cytokine, interleukin-10 (IL-10), also increased in the liver following acetaminophen administration.
Gene_expression (Expression) of CTGF in connective tissue associated with paracetamol, inflammatory mediators, inflammation, metalloproteinase and cytokine
20) Confidence 0.58 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 1.10 Pain Relevance 0.77

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox