INT927

Context Info Confidence 0.78 First Reported 1978 Last Reported 2011 Negated 9 Speculated 5 Reported most in Abstract Documents 184 Total Number 189 Disease Relevance 44.71 Pain Relevance 35.79

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)

Anatomy Link Frequency plasma 15 uterine 9 neurons 6 P19 3 CSF 3 Oxt (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 572 100.00 Neuropeptide 66 100.00 Analgesic 35 100.00 substance P 28 100.00 Enkephalin 27 100.00 anesthesia 23 100.00 Somatostatin 13 100.00 Serotonin 12 100.00 analgesia 124 99.96 antinociception 2 99.96

Disease Link Frequency Relevance Heat Anxiety Disorder 424 100.00 Targeted Disruption 192 100.00 Pollakiuria 15 99.96 Drug Dependence 46 99.92 Cocaine Dependence 3 99.92 Asthma 553 99.90 Xerostomia 39 99.84 Pain 21 99.80 Opiate Addiction 10 99.76 Embryonal Carcinoma 668 99.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, bidirectional signaling has been demonstrated between the SCN and supraoptic nucleus, another site of oxytocin synthesis destined for systemic secretion [12].

Gene_expression (synthesis) of oxytocin in supraoptic nucleus

1) Confidence 0.78 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1976559 Disease Relevance 0 Pain Relevance 0.04

Taken together, our data suggest that the reduced sodium ingestion observed in beta-endorphin deficient mice could be due to a higher expression of the OT gene.

Gene_expression (expression) of OT gene

2) Confidence 0.75 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.20 Pain Relevance 0

To investigate the role of this opioid peptide in the control of oxytocin (OT) synthesis and sodium appetite regulation we used mice with gene dosage-dependent variations in brain beta-endorphin content, expressing either 100%, 50%, or 0% of normal beta-endorphin content.

Gene_expression (synthesis) of oxytocin in brain associated with appetite loss and opioid

3) Confidence 0.75 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.26 Pain Relevance 0.27

Reduced sodium appetite and increased oxytocin gene expression in mutant mice lacking beta-endorphin.

Gene_expression (expression) of oxytocin

4) Confidence 0.75 Published 2003 Journal Neuroscience Section Title Doc Link 14580937 Disease Relevance 0.22 Pain Relevance 0.27

The mean +/- SEM total oxytocin administered was significantly less in the pulsed group (3564 +/- 487 mU) than in the continuous group (7684 +/- 844 mU; p less than 0.0001); the average dose of oxytocin administered per minute was significantly lower in the pulsed group (3.9 +/- 0.3 mU/min) than in the continuous group (7.8 +/- 0.4 mU/min; p less than 0.0001); the peak or highest administered dose of oxytocin expressed per minute was also signficantly lower in the pulsed group (9.6 +/- 0.8 mU/min) than in the continuous group (14.1 +/- 0.7 mU/min; p less than 0.0001).

Gene_expression (expressed) of oxytocin in 14.1

5) Confidence 0.75 Published 1990 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 2256497 Disease Relevance 0 Pain Relevance 0.08

The data suggests that the Avpr1b is required to drive the HPA axis response to acute antidepressant treatment and provides further evidence of a sexual dichotomy in the regulation of PVN Avp/Oxt gene expression following antidepressant administration.

Gene_expression (expression) of Oxt in PVN associated with antidepressant

6) Confidence 0.73 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.39 Pain Relevance 0.81

While oxytocin is not synthesized in the SCN, oxytocin neurons in the paraventricular nucleus of the hypothalamus are targets of vasoactive intestinal peptide secreting neurons of the suprachiamatic nucleus [10], [11].

Neg (not) Gene_expression (synthesized) of oxytocin in neurons

7) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1976559 Disease Relevance 0 Pain Relevance 0.05

We found that oxytocin levels were rhythmic in the unshifted mice (peak-to-trough amplitude of 260 pg/ml, P?

Gene_expression (levels) of oxytocin

8) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1976559 Disease Relevance 0 Pain Relevance 0.09

While oxytocin is not synthesized in the SCN, oxytocin neurons in the paraventricular nucleus of the hypothalamus are targets of vasoactive intestinal peptide secreting neurons of the suprachiamatic nucleus [10], [11].

Gene_expression (neurons) of oxytocin in neurons

9) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1976559 Disease Relevance 0 Pain Relevance 0.04

[Misoprostol and oxytocin in induction of labour in women with prolonged pregnancy--safety and effectiveness comparison].

Gene_expression ([Misoprostol) of oxytocin associated with prolonged pregnancy

10) Confidence 0.67 Published 2001 Journal Wiad. Lek. Section Title Doc Link 11928554 Disease Relevance 0.27 Pain Relevance 0.08

[External fetal electrocardiography, the maternal effort test and the oxytocin challenge in cases of fetomaternal rhesus isoimmunisation (author's transl)].

Gene_expression (challenge) of oxytocin in External

11) Confidence 0.66 Published 1979 Journal J Gynecol Obstet Biol Reprod (Paris) Section Title Doc Link 113446 Disease Relevance 0.10 Pain Relevance 0.12

There was no significant increase in plasma oxytocin levels during this study in either test responders or nonresponders.

Gene_expression (levels) of oxytocin in plasma

12) Confidence 0.66 Published 1986 Journal Am J Perinatol Section Abstract Doc Link 3942612 Disease Relevance 0.43 Pain Relevance 0.17

However, the precise magnitude of the increased risk cannot be accurately determined. 4) Certain basic safety requirements such as available operating room facilities and adequate personnel for careful observation are mandatory, but other management policies that remain controversial include use of regional anesthesia, oxytocin administration, timing of hospital admission, artificial rupture of membranes, mode of delivery, proper method to evaluate the uterine scar, and delivery of fetuses in breech presentation and twins. 5) A policy of selective vaginal deliveries among patients with prior cesarean sections will result in cost reductions due to decreased postpartum hospitalization.

Gene_expression (administration) of oxytocin in uterine associated with cicatrix, breech presentation, rupture and regional anesthesia

13) Confidence 0.66 Published 1982 Journal Obstet Gynecol Section Abstract Doc Link 7078857 Disease Relevance 0.66 Pain Relevance 0.10

Haemodynamic effects of oxytocin (syntocinon) and methyl ergometrine (methergin) on the systemic and pulmonary circulations of pregnant anaesthetized women.

Gene_expression (effects) of oxytocin

14) Confidence 0.66 Published 1978 Journal Acta Obstet Gynecol Scand Section Title Doc Link 636863 Disease Relevance 0.15 Pain Relevance 0.09

These data support the hypothesis that oxytocin acts directly on myometrial cells and not primarily by prior generation of prostaglandin synthesis in the membranes.

Neg (not) Gene_expression (acts) of oxytocin

15) Confidence 0.66 Published 1986 Journal Obstet Gynecol Section Abstract Doc Link 3763070 Disease Relevance 0.10 Pain Relevance 0.10

However, the requirement for oxytocin augmentation during the first and second stages of labour was significantly less in the lignocaine group (p = 0.004).

Gene_expression (augmentation) of oxytocin

16) Confidence 0.66 Published 1992 Journal Anaesthesia Section Abstract Doc Link 1489026 Disease Relevance 0.25 Pain Relevance 0.29

There was a significant reduction in the requirement for oxytocin augmentation in women treated with PGE2: primigravidae, odds ratio (OR), 0.27 and 95% confidence interval (CI), 0.12-0.61; multiparae, OR, 0.19 and 95% CI, 0.08-0.45.

Gene_expression (augmentation) of oxytocin in PGE2

17) Confidence 0.66 Published 1995 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 7774735 Disease Relevance 0 Pain Relevance 0.50

The effect of a potent oxytocin antagonist, produced in our laboratories, on spontaneous uterine contractions in the pregnant baboon was examined.

Gene_expression (produced) of oxytocin in uterine associated with antagonist and dismenorea

18) Confidence 0.66 Published 1990 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 2256498 Disease Relevance 0.26 Pain Relevance 0.43

Patients who had increased uterine contractions had significantly higher plasma oxytocin levels but lower PGFM levels than those without contractions.

Gene_expression (levels) of oxytocin in uterine associated with dismenorea

19) Confidence 0.66 Published 1991 Journal Obstet Gynecol Section Abstract Doc Link 2030861 Disease Relevance 0.27 Pain Relevance 0.10

Oxytocin was not used in this study.

Neg (not) Gene_expression (used) of Oxytocin

20) Confidence 0.66 Published 1987 Journal Am J Perinatol Section Abstract Doc Link 3566882 Disease Relevance 0.07 Pain Relevance 0.24

General Comments

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