INT92716

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Context Info
Confidence 0.51
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.82
Pain Relevance 6.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PAG1) plasma membrane (PAG1) intracellular (PAG1)
Anatomy Link Frequency
hypothalamus 1
brain 1
ventral 1
PAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 182 100.00 Very High Very High Very High
Pain 138 100.00 Very High Very High Very High
Chronic low back pain 63 100.00 Very High Very High Very High
Thalamus 19 100.00 Very High Very High Very High
insula 13 100.00 Very High Very High Very High
Periaqueductal grey 6 100.00 Very High Very High Very High
medulla 5 100.00 Very High Very High Very High
Anterior cingulate cortex 3 100.00 Very High Very High Very High
Nucleus accumbens 8 99.96 Very High Very High Very High
analgesia 5 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 248 100.00 Very High Very High Very High
Pain 170 100.00 Very High Very High Very High
Low Back Pain 64 100.00 Very High Very High Very High
Nociception 6 99.84 Very High Very High Very High
Stress 198 98.72 Very High Very High Very High
Knee Osteoarthritis 75 94.88 High High
Panic Disorder 66 88.36 High High
INFLAMMATION 3 88.12 High High
Anxiety Disorder 125 86.04 High High
Neuropathic Pain 11 80.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extent to which lidocaine can penetrate these injured structures in the deep tissue may be one explanation for its better effectiveness in CBP.
Negative_regulation (effectiveness) of CBP associated with chronic low back pain, deep tissue and lidocaine
1) Confidence 0.51 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584040 Disease Relevance 1.52 Pain Relevance 2.30
that electrical and chemical stimulations of the PAG cause urgent defensive
Negative_regulation (defensive) of PAG associated with urological neuroanatomy
2) Confidence 0.36 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2654309 Disease Relevance 1.23 Pain Relevance 0.33
Blood flow measurement using functional magnetic resonance imaging and positron emission tomography (PET) has revealed that analgesia is related to decreased neural activities in pain-modulatory brain regions, such as the rostral anterior cingulate cortex (rACC), insula, thalamus, and brainstem including periaqueductal gray (PAG) and ventromedial medulla.
Negative_regulation (decreased) of PAG in brain associated with pain, insula, thalamus, central grey, anterior cingulate cortex, analgesia, medulla, positron emission tomography and imagery
3) Confidence 0.32 Published 2009 Journal Neurosci Bull Section Abstract Doc Link 19784082 Disease Relevance 0.53 Pain Relevance 1.63
These animals had a decreased activity of dynorphin B-ir in the nucleus accumbens, decreased levels of MEAP-ir in the periaqueductal gray (PAG) and higher levels of MEAP-ir in the hypothalamus compared to controls.
Negative_regulation (decreased) of PAG in hypothalamus associated with nucleus accumbens, dynorphin, urological neuroanatomy and central grey
4) Confidence 0.18 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11124391 Disease Relevance 0.26 Pain Relevance 0.71
We conclude that a component of PAG mediated inhibition of nociception is inactive under normal conditions.
Negative_regulation (inhibition) of PAG associated with nociception and periaqueductal grey
5) Confidence 0.07 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11154838 Disease Relevance 0.99 Pain Relevance 0.80
ventral PAG are normally delayed
Negative_regulation (delayed) of PAG in ventral associated with central grey
6) Confidence 0.05 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.56 Pain Relevance 0.22
This was done by converting the raw PAG and raw whole section densitometry data to OD
Negative_regulation (converting) of PAG associated with central grey
7) Confidence 0.05 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.73 Pain Relevance 0.34

General Comments

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