INT92733

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Context Info
Confidence 0.51
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 8.56
Pain Relevance 17.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) cell adhesion (Ephb1)
plasma membrane (Ephb1) kinase activity (Ephb1) cytoplasm (Ephb1)
Anatomy Link Frequency
nucleus accumbens 2
retina 1
neuron 1
striatum 1
cortex 1
Ephb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 383 99.98 Very High Very High Very High
withdrawal 105 99.90 Very High Very High Very High
Desipramine 68 99.90 Very High Very High Very High
antidepressant 4 99.84 Very High Very High Very High
Morphine 207 99.68 Very High Very High Very High
Dopamine 156 99.60 Very High Very High Very High
hyperexcitability 60 99.48 Very High Very High Very High
local anesthetic 21 99.22 Very High Very High Very High
intrathecal 15 99.20 Very High Very High Very High
Antinociceptive 1 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 74 99.50 Very High Very High Very High
Nervous System Injury 130 99.32 Very High Very High Very High
Convulsion 31 98.68 Very High Very High Very High
Hyperalgesia 210 97.84 Very High Very High Very High
Hypersensitivity 20 94.48 High High
Morphine Dependence 135 93.88 High High
Nociception 10 90.24 High High
Neuropathic Pain 210 90.00 High High
Injury 30 89.08 High High
Handedness 12 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of Na(+) channels by local anesthetics may regulate desipramine-induced down-regulation of NET function.
Negative_regulation (regulation) of NET associated with desipramine and local anesthetic
1) Confidence 0.51 Published 2006 Journal Brain Res. Section Abstract Doc Link 16725121 Disease Relevance 0.39 Pain Relevance 1.47
We began by confirming and extending our earlier demonstrations in rats that multiple intrathecal administration (i.t.) of EphB receptor blocking reagent EphB1-Fc or EphB2-Fc can inhibit production of CCI-induced thermal hyperalgesia [29].
Negative_regulation (blocking) of EphB1 associated with thermal hyperalgesia and intrathecal
2) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.35 Pain Relevance 1.15
If so, loss of postsynaptic EphB1 receptor in the EphB1-/- mice may result in loss of reverse signaling and therefore the subsequent activities.
Negative_regulation (loss) of EphB1
3) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.30 Pain Relevance 1.21
The present study further shows that the behavioral signs of morphine withdrawal are prevented in EphB1 receptor protein-null mice.
Negative_regulation (prevented) of EphB1 associated with withdrawal and morphine
4) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.93 Pain Relevance 0.96
Nerve injury-induced DRG neuron hyperexcitability are prevented or largely diminished in EphB1-/- and EphB1+/- mice
Negative_regulation (diminished) of EphB1 in neuron associated with nervous system injury and hyperexcitability
5) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.02 Pain Relevance 0.78
The co-administration of local anesthetics with desipramine reversed the behavioral sensitization and down-regulation of NET function induced by desipramine.
Negative_regulation (down-regulation) of NET associated with desipramine and local anesthetic
6) Confidence 0.43 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17981365 Disease Relevance 0.09 Pain Relevance 0.81
The signaling would be lost in the knockout or down mice DRG due to loss of the postsynaptic EphB1.
Negative_regulation (loss) of EphB1 associated with targeted disruption
7) Confidence 0.38 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.15 Pain Relevance 0.98
Alterations of norepinephrine transporter (NET) function by chronic inhibition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied in mice.
Negative_regulation (inhibition) of NET associated with convulsion, local anesthetic and cocaine
8) Confidence 0.38 Published 2006 Journal Brain Res. Section Abstract Doc Link 16725121 Disease Relevance 0.28 Pain Relevance 0.63
These results suggest that down-regulation of hippocampal NET induced by chronic administration of desipramine may be relevant to desipramine-induced sensitization of lidocaine convulsions.
Negative_regulation (regulation) of NET associated with desipramine, convulsion and lidocaine
9) Confidence 0.38 Published 2006 Journal Brain Res. Section Abstract Doc Link 16725121 Disease Relevance 0.42 Pain Relevance 1.51
Daily administration of desipramine, an inhibitor of the NET, for 5 days decreased [(3)H]norepinephrine uptake in the P2 fractions of hippocampus but not cortex, striatum or amygdalae.
Negative_regulation (inhibitor) of NET in striatum associated with desipramine and hippocampus
10) Confidence 0.38 Published 2006 Journal Brain Res. Section Abstract Doc Link 16725121 Disease Relevance 0.30 Pain Relevance 0.90
To test this idea, we studied mice lacking a functional NET in spontaneous and morphine-induced antinociceptive paradigms.
Negative_regulation (lacking) of NET associated with antinociceptive and morphine
11) Confidence 0.37 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11124980 Disease Relevance 0.23 Pain Relevance 1.52
In mice lacking EphB1, expression of Sert in the retina was maintained in a pattern indistinguishable from wild type (Figure 8B).
Negative_regulation (lacking) of EphB1 in retina
12) Confidence 0.31 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.20 Pain Relevance 0
Long-term inhibition of the NET by antidepressants has been reported to change the density and function of pre- and postsynaptic ARs, which may contribute to the antidepressant effects of NET inhibitors such as desipramine.
Negative_regulation (inhibition) of NET associated with desipramine and antidepressant
13) Confidence 0.30 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16417582 Disease Relevance 0.07 Pain Relevance 0.24
If true, cocaine could elevate DA levels through its inhibition of the NET.
Negative_regulation (inhibition) of NET associated with dopamine and cocaine
14) Confidence 0.22 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12006604 Disease Relevance 0.16 Pain Relevance 1.19
We report that both cocaine and desipramine, a potent NET inhibitor, failed to change DA clearance or evoked release in the NAc of mutant mice.
Negative_regulation (inhibitor) of NET in NAc associated with nucleus accumbens, dopamine, desipramine and cocaine
15) Confidence 0.22 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12006604 Disease Relevance 0.15 Pain Relevance 1.22
Together with recent microdialysis data, these results support the hypothesis that prefrontal cortical NET blockade and consequent enhancement of prefrontal cortical extracellular dopamine mediates the reversal of PPI deficits in DAT KO mice.
Negative_regulation (blockade) of NET in prefrontal associated with dopamine
16) Confidence 0.14 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16407898 Disease Relevance 0.13 Pain Relevance 0.40
It is not clear whether cocaine inhibition of SERT or NET enhances or dampens locomotor stimulation in wild type mice where DAT is also inhibited.
Spec (whether) Negative_regulation (inhibition) of NET associated with cocaine
17) Confidence 0.14 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.61
Daily administration of desipramine, an inhibitor of the NET, for 5 days decreased [(3)H]norepinephrine uptake in the P2 fractions of hippocampus but not cortex, striatum or amygdalae.
Negative_regulation (inhibitor) of NET in cortex associated with desipramine and hippocampus
18) Confidence 0.13 Published 2006 Journal Brain Res. Section Abstract Doc Link 16725121 Disease Relevance 0.30 Pain Relevance 0.90
For example, inhibition of SERT or NET with selective inhibitors elevates DA levels in the nucleus accumbens and produces reward in DAT-KO mice but not in wild type mice [24].
Negative_regulation (inhibition) of NET in nucleus accumbens associated with nucleus accumbens and dopamine
19) Confidence 0.10 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.05 Pain Relevance 0.50
Cocaine inhibition of DAT, SERT, and NET and the resulting enhancement of neurotransmission in all three systems may contribute to the locomotor effect in wild type mice.
Negative_regulation (inhibition) of NET associated with cocaine
20) Confidence 0.10 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.73

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