INT92734

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.86
Pain Relevance 7.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) cell adhesion (Ephb1)
plasma membrane (Ephb1) kinase activity (Ephb1) cytoplasm (Ephb1)
Anatomy Link Frequency
nerve 1
Ephb1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 63 99.92 Very High Very High Very High
addiction 114 99.88 Very High Very High Very High
Morphine 125 99.48 Very High Very High Very High
long-term potentiation 252 99.00 Very High Very High Very High
Hyperalgesia 84 98.92 Very High Very High Very High
spinal dorsal horn 153 98.68 Very High Very High Very High
Eae 7 98.34 Very High Very High Very High
Pain 42 98.24 Very High Very High Very High
hyperexcitability 36 98.08 Very High Very High Very High
analgesia 11 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Morphine Dependence 81 99.88 Very High Very High Very High
Hyperalgesia 150 98.92 Very High Very High Very High
Neuropathic Pain 135 98.68 Very High Very High Very High
Pain 51 98.24 Very High Very High Very High
Nervous System Injury 81 97.88 Very High Very High Very High
Nociception 9 85.20 High High
Targeted Disruption 35 82.92 Quite High
Stress 1 78.60 Quite High
Opiate Addiction 33 76.00 Quite High
Drug Dependence 12 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EphB1 receptor is necessary for development of neuropathic hyperalgesia and morphine dependence
EphB1 Binding (receptor) of associated with addiction, hyperalgesia, neuropathic pain and morphine
1) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.41 Pain Relevance 1.70
EphB1 receptor is necessary for development of sensory neuron hyperexcitability after nerve injury
EphB1 Binding (receptor) of in nerve associated with nervous system injury and hyperexcitability
2) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.04 Pain Relevance 1.12
The present study further shows that binding to the EphB1 receptor is required for ephrinBs such as ephrinB1-Fc, which may also bind to EphB1-4 and EphA4 receptors, to promote behavioral hyperalgesia and that the EphB1 receptor protein-null mutant mice fail to development hyperalgesia or morphine dependence.
EphB1 Binding (binding) of associated with addiction, hyperalgesia and morphine
3) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.18 Pain Relevance 1.40
LTP in the mouse DH in vivo was prevented by either EphB2-Fc or targeted mutation of EphB1 receptor
EphB1 Binding (receptor) of associated with spinal dorsal horn and long-term potentiation
4) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.43
EphB1 receptor, a mechanism underlying LTP
EphB1 Binding (receptor) of associated with long-term potentiation
5) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.43
Activation of CaMKII, ERK and CREB proteins and expression of c-Fos following HFS were prevented by either EphB2-Fc or targeted mutation of the EphB1 receptor
EphB1 Binding (receptor) of
6) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.36
In the NET-KO mice, DMI did not further enhance analgesia but was still able to produce inhibitory effects on the locomotor activity of these mutants, suggesting that the effects of this TCA are not exclusively via interactions with the NET.
NET Neg (not) Binding (interactions) of associated with desipramine, eae and analgesia
7) Confidence 0.31 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11124980 Disease Relevance 0.23 Pain Relevance 1.57

General Comments

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