INT92738

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Context Info
Confidence 0.00
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.43
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) cell adhesion (Ephb1)
plasma membrane (Ephb1) kinase activity (Ephb1) cytoplasm (Ephb1)
Ephb1 (Mus musculus)
Tcas1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tricyclic antidepressant 10 100.00 Very High Very High Very High
Analgesic 4 99.76 Very High Very High Very High
analgesia 10 98.72 Very High Very High Very High
opiate 4 98.34 Very High Very High Very High
antinociception 6 97.80 Very High Very High Very High
agonist 2 94.84 High High
Morphine 4 93.52 High High
Antinociceptive 2 92.16 High High
Desipramine 6 89.40 High High
Eae 2 88.36 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 80.48 Quite High
Stress 2 70.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, these results demonstrate in a genetic model that both endogenous and exogenous opiate-mediated analgesia can be enhanced by elimination of the NET, indicating that the interaction of TCAs with NET mediates these effects.
NET Binding (interaction) of TCAs associated with opiate, tricyclic antidepressant and analgesia
1) Confidence 0.00 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11124980 Disease Relevance 0.21 Pain Relevance 1.19
It has been postulated that the analgesic effects of TCAs are determined by their ability to inhibit norepinephrine reuptake via interactions with the NET.
NET Binding (interactions) of TCAs associated with analgesic and tricyclic antidepressant
2) Confidence 0.00 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11124980 Disease Relevance 0.22 Pain Relevance 1.48

General Comments

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