INT92741

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.44
Pain Relevance 6.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
neuronal 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 20 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 5 100.00 Very High Very High Very High
Morphine 183 99.98 Very High Very High Very High
Kinase C 78 99.80 Very High Very High Very High
Hippocampus 12 98.72 Very High Very High Very High
tolerance 57 98.64 Very High Very High Very High
Periaqueductal grey 36 97.12 Very High Very High Very High
Spinal cord 19 96.08 Very High Very High Very High
opioid receptor 170 94.68 High High
Lasting pain 4 93.92 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 36 97.12 Very High Very High Very High
Nociception 16 94.80 High High
Pain 6 93.92 High High
Targeted Disruption 26 93.88 High High
Injury 29 91.68 High High
Stress 3 89.36 High High
Cv Unclassified Under Development 25 72.16 Quite High
Apoptosis 15 67.80 Quite High
Necrosis 8 67.24 Quite High
Sprains And Strains 19 54.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The MOR(-/-) mice showed a significantly higher morphine-induced nNOS expression level (+103%) or a lower cocaine-induced nNOS expression level (+38%) in the DG than in the morphine- or cocaine-treated MOR(+/+) mice.
Positive_regulation (induced) of Positive_regulation (induced) of nNOS associated with hippocampus, cocaine and morphine
1) Confidence 0.47 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300892 Disease Relevance 0.08 Pain Relevance 1.73
The MOR(-/-) mice showed a significantly higher morphine-induced nNOS expression level (+103%) or a lower cocaine-induced nNOS expression level (+38%) in the DG than in the morphine- or cocaine-treated MOR(+/+) mice.
Positive_regulation (induced) of Positive_regulation (induced) of nNOS associated with hippocampus, cocaine and morphine
2) Confidence 0.47 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300892 Disease Relevance 0.08 Pain Relevance 1.73
Moreover, we discovered that agmatine causes a 3-fold increase in the NADPH oxidase activity of nNOS leading to the production of H2O2 and is a likely cause for the inactivation of the enzyme.
Positive_regulation (increase) of Positive_regulation (leading) of nNOS
3) Confidence 0.44 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11125020 Disease Relevance 0.09 Pain Relevance 0.11
The present study was designed to determine whether high-dose i.t. morphine could influence the activation of the extracellular signal-regulated kinase (ERK), a mitogen-activated protein (MAP) kinase in neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS) activation.
Positive_regulation (activation) of Positive_regulation (activation) of nNOS in neuronal associated with neuronal nitric oxide synthase and morphine
4) Confidence 0.42 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17353023 Disease Relevance 0.17 Pain Relevance 0.76
Importantly, the action of nNOS and those of exogenous NO are exerted downstream of mitoKATP channels and upstream of p38 MAPK.
Positive_regulation (exerted) of Positive_regulation (action) of nNOS
5) Confidence 0.41 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.68 Pain Relevance 0.12
In summary, early activation of Akt and nNOS initiates the PKC?
Positive_regulation (initiates) of Positive_regulation (activation) of nNOS associated with kinase c
6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.11
Interestingly, NMDAR signaling elicits nNOS activation via the PI3K-Akt pathway [38].
Positive_regulation (elicits) of Positive_regulation (activation) of nNOS
7) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.19 Pain Relevance 0.88
Western blot analysis confirmed the immunolabeling results obtained in situ, and indicated that axotomy did not result in statistically significant nNOS activity upregulation (Figure 6E).
Neg (not) Positive_regulation (result) of Positive_regulation (upregulation) of nNOS
8) Confidence 0.30 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.15 Pain Relevance 0.15

General Comments

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