INT92755

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Context Info
Confidence 0.27
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 3.63
Pain Relevance 7.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MRGPRX1) signal transducer activity (MRGPRX1)
Anatomy Link Frequency
sensory nerve 1
ovary 1
MRGPRX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 542 100.00 Very High Very High Very High
Analgesic 20 99.44 Very High Very High Very High
Enkephalin 22 99.42 Very High Very High Very High
Cannabinoid receptor 6 99.32 Very High Very High Very High
Neurotransmitter 4 98.68 Very High Very High Very High
opiate 9 98.62 Very High Very High Very High
Opioid 98 98.48 Very High Very High Very High
opioid receptor 213 98.34 Very High Very High Very High
antagonist 132 98.12 Very High Very High Very High
Pain 107 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 215 99.86 Very High Very High Very High
Disease 63 99.16 Very High Very High Very High
Pain 139 98.12 Very High Very High Very High
INFLAMMATION 117 97.76 Very High Very High Very High
Metabolic Syndrome 2 97.12 Very High Very High Very High
Bordatella Infection 34 93.76 High High
Diabetes Mellitus 2 91.04 High High
Starvation 5 87.76 High High
Osteoporosis 2 84.40 Quite High
Pressure And Volume Under Development 11 82.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate the generally important role for PLD2 in the regulation of agonist-dependent and agonist-independent G protein-coupled receptor (GPCR) endocytosis.
Regulation (regulation) of GPCR associated with agonist
1) Confidence 0.27 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16539674 Disease Relevance 0 Pain Relevance 0.67
Endocytic membrane trafficking plays multiple roles in GPCR signaling and regulation.
Regulation (regulation) of GPCR
2) Confidence 0.27 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607249 Disease Relevance 0 Pain Relevance 0.14
This information is essential to the design of oligomerization-disrupting mutants directed towards modulating GPCR function.
Regulation (modulating) of GPCR
3) Confidence 0.26 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
Antibodies that selectively target GPCR oligomers will also be included in the information system.

10.

Regulation (target) of GPCR
4) Confidence 0.26 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0.05
However, such heterodimer specific allosteric ligands offer obvious opportunities, modulating the function of the partner GPCR only in the presence of the orthosteric ligand for that receptor and doing so only in cells and tissues in which the relevant heterodimer is expressed [25].
Regulation (modulating) of GPCR
5) Confidence 0.26 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.07
The six major GPCR clades identified in this study represent the distance down the tree from the tips the ancestor reconstruction analysis could be carried out before the distance between ancestors exceeded our value for ?
Regulation (six) of GPCR
6) Confidence 0.22 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684142 Disease Relevance 0 Pain Relevance 0
The scope of the data presented suggests this occurs by direct interaction with a structural motif common to a large number of GPCRs or by activation/inhibition of an unidentified accessory protein that regulates GPCR function.
Regulation (regulates) of GPCR
7) Confidence 0.22 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11125021 Disease Relevance 0.06 Pain Relevance 0.30
Cannabinoid receptors remain one of the most important GPCR drug discovery target due to the intense interest in CB(1) receptor antagonists for treating obesity and metabolic syndrome.
Regulation (target) of GPCR associated with cannabinoid receptor, antagonist and metabolic syndrome
8) Confidence 0.18 Published 2007 Journal Recent patents on CNS drug discovery Section Abstract Doc Link 18221221 Disease Relevance 0.34 Pain Relevance 0.70
To further complicate the relationship between GPCR responsiveness and asthma, evidence suggests that both glucocorticoids and beta-agonists, the two most widely used drugs in the treatment of asthma, also regulate GPCR responsiveness, primarily via changes in receptor expression and coupling.
Regulation (regulate) of GPCR associated with asthma and agonist
9) Confidence 0.17 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.53 Pain Relevance 0.23
Taken together, these data provide evidence that M6a may act as a scaffolding molecule in the regulation of GPCR endocytosis and intracellular trafficking.
Regulation (regulation) of GPCR
10) Confidence 0.16 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17548356 Disease Relevance 0 Pain Relevance 0.63
RSNOs modulate GPCR signaling in native tissues in a highly receptor-specific manner
Regulation (modulate) of GPCR
11) Confidence 0.16 Published 2005 Journal BMC Cell Biol Section Body Doc Link PMC1090567 Disease Relevance 0 Pain Relevance 0.07
The top four panels show the histograms of the degree of drugs targeting enzyme, ion channel, GPCR and nuclear receptor, respectively.
Regulation (targeting) of GPCR
12) Confidence 0.15 Published 2008 Journal Bioinformatics Section Body Doc Link PMC2718640 Disease Relevance 0 Pain Relevance 0
A pharmacologically important question is to what extent does phylogenetic mosaicism affect GPCR function?
Regulation (affect) of GPCR
13) Confidence 0.13 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684142 Disease Relevance 0 Pain Relevance 0
However, Shore, Fredberg, and colleagues have developed a model for examining agonist-induced changes in stiffness of cultured ASM cells that has provided useful information linking regulation of GPCR signaling with ASM contractile state [23].
Regulation (regulation) of GPCR associated with agonist
14) Confidence 0.13 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.09 Pain Relevance 0.05
On another level we can consider the contribution of altered GPCR responsiveness to a given level of agonist presented to ASM, such that the sum of GPCR-generated signals results in higher than normal increases in intracellular calcium.
Regulation (contribution) of GPCR associated with agonist
15) Confidence 0.13 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.43 Pain Relevance 0.31
Agonist-promoted receptor endocytosis significantly affects the pharmacodynamics of a GPCR but is not yet investigated for hMrgX1.
Regulation (affects) of GPCR associated with agonist
16) Confidence 0.12 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20424127 Disease Relevance 0.09 Pain Relevance 0.37
Furthermore, we demonstrate that the GPCR models can be more sensitive in determining ligand specificity than sequence-based methods, as is evidenced by the TASSER model of RDC1.
Regulation (sensitive) of GPCR
17) Confidence 0.11 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1364505 Disease Relevance 0 Pain Relevance 0.04
In such a situation the ligand at the first GPCR would act as an allosteric agent for the orthosteric agonist of the second GPCR and this would be a heterodimer-specific effect [25] because the ligand would display no direct effect on the second GPCR in assays in which the second GPCR was expressed alone.
Neg (no) Regulation (effect) of GPCR associated with agonist
18) Confidence 0.11 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.22
Fig. 1.Scatter-plots of pharmacological effect similarity scores and chemical structure similarity scores for drugs targeting enzyme, ion channel, GPCR and nuclear receptor, respectively.
Regulation (targeting) of GPCR
19) Confidence 0.11 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2881361 Disease Relevance 0 Pain Relevance 0
We learned that the degree of allosteric enhancement is dependent on the orthosteric ligand examined, which was quantified using a mathematical model [19], adding further subtlety to this new concept of GPCR regulation.


Regulation (regulation) of GPCR
20) Confidence 0.08 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.64

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