INT92774

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.47
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PVALB)
Anatomy Link Frequency
caudate nucleus 2
globus pallidus 2
cortex 1
PVALB (Homo sapiens)
Pain Link Frequency Relevance Heat
Limbic system 5 99.04 Very High Very High Very High
Serotonin 24 98.94 Very High Very High Very High
substance P 5 97.04 Very High Very High Very High
Enkephalin 6 96.16 Very High Very High Very High
Dynorphin 4 96.08 Very High Very High Very High
gABA 7 92.60 High High
Thalamus 41 91.96 High High
Neurotransmitter 15 88.08 High High
Neuropeptide 5 86.56 High High
Central nervous system 2 84.52 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 8 89.52 High High
Syndrome 312 88.40 High High
Congenital Anomalies 24 87.40 High High
Disease 12 81.20 Quite High
Tics 248 68.84 Quite High
Aggression 4 57.24 Quite High
Dystonia 8 17.68 Low Low
Anxiety Disorder 28 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 20 5.00 Very Low Very Low Very Low
Obsessive-compulsive Disorder 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we carried out histochemical and immunohistochemical procedures in the Pa of normal individuals to visualize the pattern of distribution of acetylcholinesterase (AChE), calbindin D-28k (CB), parvalbumin (PV), calretinin (CR), limbic system-associated membrane protein (LAMP), substance P (SP), and enkephalin (ENK).
Gene_expression (distribution) of parvalbumin associated with enkephalin, limbic system and substance p
1) Confidence 0.37 Published 2004 Journal Synapse Section Abstract Doc Link 14666515 Disease Relevance 0 Pain Relevance 0.38
Calcium binding proteins, calbindin D28K and parvalbumin, make their first appearance in the cortex and deep nuclei at 14 weeks and then their expression decreases toward term, while calretinin appears later at 21 weeks but its expression increases with fetal age.
Gene_expression (expression) of parvalbumin in cortex
2) Confidence 0.37 Published 2000 Journal Histochem. J. Section Abstract Doc Link 11127973 Disease Relevance 0 Pain Relevance 0.59
For example, studies have reported decreased levels of dynorphin-like immunoreactivity in the striatum and globus pallidus (Haber et al 1986; Haber and Wolfer 1992), decreased subcortical levels of serotonin (Anderson et al 1992), increased numbers of neurons expressing parvalbumin in the globus pallidus pars internus (GPi) and decreased numbers of neurons expressing parvalbumin in the caudate nucleus and globus pallidus pars externus (GPe) (Kalanithi et al 2005).
Gene_expression (expressing) of parvalbumin in globus pallidus associated with dynorphin and serotonin
3) Confidence 0.09 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646643 Disease Relevance 0.84 Pain Relevance 0.17
For example, studies have reported decreased levels of dynorphin-like immunoreactivity in the striatum and globus pallidus (Haber et al 1986; Haber and Wolfer 1992), decreased subcortical levels of serotonin (Anderson et al 1992), increased numbers of neurons expressing parvalbumin in the globus pallidus pars internus (GPi) and decreased numbers of neurons expressing parvalbumin in the caudate nucleus and globus pallidus pars externus (GPe) (Kalanithi et al 2005).
Gene_expression (expressing) of parvalbumin in globus pallidus associated with dynorphin and serotonin
4) Confidence 0.09 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646643 Disease Relevance 0.89 Pain Relevance 0.16
For example, studies have reported decreased levels of dynorphin-like immunoreactivity in the striatum and globus pallidus (Haber et al 1986; Haber and Wolfer 1992), decreased subcortical levels of serotonin (Anderson et al 1992), increased numbers of neurons expressing parvalbumin in the globus pallidus pars internus (GPi) and decreased numbers of neurons expressing parvalbumin in the caudate nucleus and globus pallidus pars externus (GPe) (Kalanithi et al 2005).
Gene_expression (expressing) of parvalbumin in caudate nucleus associated with dynorphin and serotonin
5) Confidence 0.03 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646643 Disease Relevance 0.84 Pain Relevance 0.17
For example, studies have reported decreased levels of dynorphin-like immunoreactivity in the striatum and globus pallidus (Haber et al 1986; Haber and Wolfer 1992), decreased subcortical levels of serotonin (Anderson et al 1992), increased numbers of neurons expressing parvalbumin in the globus pallidus pars internus (GPi) and decreased numbers of neurons expressing parvalbumin in the caudate nucleus and globus pallidus pars externus (GPe) (Kalanithi et al 2005).
Gene_expression (expressing) of parvalbumin in caudate nucleus associated with dynorphin and serotonin
6) Confidence 0.03 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646643 Disease Relevance 0.89 Pain Relevance 0.16

General Comments

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