INT92777

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 7.49
Pain Relevance 9.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ABAT)
Anatomy Link Frequency
brain 8
neurons 6
neuronal 4
epithelial cells 2
interneurons 2
ABAT (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 246 100.00 Very High Very High Very High
agonist 43 100.00 Very High Very High Very High
Nicotine 9 99.98 Very High Very High Very High
Gabapentin 45 99.96 Very High Very High Very High
cytokine 6 99.66 Very High Very High Very High
Glutamate 48 99.48 Very High Very High Very High
cocaine 92 99.16 Very High Very High Very High
dorsal root ganglion 21 99.00 Very High Very High Very High
GABAergic 65 97.86 Very High Very High Very High
Neurotransmitter 64 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 30 100.00 Very High Very High Very High
Convulsion 22 99.38 Very High Very High Very High
Ganglion Cysts 21 99.00 Very High Very High Very High
Recurrence 16 98.72 Very High Very High Very High
Frailty 13 94.48 High High
Hyperalgesia 2 93.92 High High
Amphetamine Dependence 3 93.84 High High
Manic Depressive Disorder 26 92.96 High High
Neuropathic Pain 19 92.92 High High
Epilepsy 27 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, gabapentin has not been identified as a GABA reuptake inhibitor, and it is not converted to a GABA agonist.15,17 Gabapentin is a ligand of the ?
Neg (not) Positive_regulation (converted) of Gene_expression (agonist.15,17) of GABA associated with gaba, agonist and gabapentin
1) Confidence 0.44 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987504 Disease Relevance 0.34 Pain Relevance 1.25
In addition to increasing cerebral levels of GABA and facilitating GABA neurotransmission (Kuzniecky et al., 1998), topiramate weakens the action of glutamate, a neurotransmitter that opposes GABA’s potentially therapeutic reduction of dopamine activity.
Positive_regulation (increasing) of Gene_expression (levels) of GABA associated with dopamine, neurotransmitter, glutamate and gaba
2) Confidence 0.40 Published 2008 Journal Addiction Science & Clinical Practice Section Body Doc Link PMC2797110 Disease Relevance 0.48 Pain Relevance 0.82
In general, the magnitude of the excitability index change produced by GABA (30 µM) or muscimol (30 µM) increases with increasing basal stimulus rate, i.e. as the prevailing excitability index decreases (Figure 3C & 5D).


Positive_regulation (increases) of Gene_expression (produced) of GABA associated with gaba
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0 Pain Relevance 0.60
This suggests that the sequential activation of nicotinic signaling followed by GABAergic signaling is necessary for nicotine to stimulate bronchial epithelial mucus production, and that nicotine-induced mucin overproduction is, in part, dependent on GABA-A receptor signaling in bronchial epithelial cells.
Positive_regulation (induced) of Gene_expression (overproduction) of GABA in epithelial cells associated with gaba, nicotine and gabaergic
4) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.20 Pain Relevance 0.84
GABA expression is gradually upregulated toward term forming networks of GABA-positive fibers and neurons.
Positive_regulation (upregulated) of Gene_expression (expression) of GABA in neurons associated with gaba
5) Confidence 0.23 Published 2000 Journal Histochem. J. Section Abstract Doc Link 11127973 Disease Relevance 0 Pain Relevance 0.62
Because glutamate is the substrate for GAD-mediated GABA biosynthesis, we examined MSCs for glutamate expression during the entire course of neuronal induction (Fig. 2C).
Positive_regulation (mediated) of Gene_expression (biosynthesis) of GABA in neuronal associated with gaba and glutamate
6) Confidence 0.10 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.65 Pain Relevance 0.87
This pathway, referred to as “tuberoinfundibular-GABA (TI-GABA) system”, has been shown to modulate prolactin secretion in humans, possibly through serotoninergic stimulation of GABA interneurons (that express the 5HT1A membrane receptor) resulting in inhibition of TIDA cells and prolactin secretion (Emiliano and Fudge 2004).
Spec (possibly) Positive_regulation (stimulation) of Gene_expression (interneurons) of GABA in interneurons associated with gaba
7) Confidence 0.08 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0 Pain Relevance 0.54
In the human brain, valproic acid affects neurotransmitter GABA function by potentiating GABA inhibitory activity by several means, including inhibition of GABA degradation, increased GABA synthesis, and decreased GABA turnover.
Positive_regulation (increased) of Gene_expression (synthesis) of GABA in brain associated with gaba and neurotransmitter
8) Confidence 0.07 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.38 Pain Relevance 0.34
We also found that subcutaneous inoculation of rdvGAD67 resulted in enhanced production of GAD and tonical GABA release from transduced DRG neurons.
Positive_regulation (resulted) of Gene_expression (production) of GABA in neurons associated with dorsal root ganglion, gaba and generalized anxiety disorder
9) Confidence 0.05 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18180106 Disease Relevance 1.41 Pain Relevance 1.01
We also found that subcutaneous inoculation of rdvGAD67 resulted in enhanced production of GAD and tonical GABA release from transduced DRG neurons.
Positive_regulation (enhanced) of Gene_expression (production) of GABA in neurons associated with dorsal root ganglion, gaba and generalized anxiety disorder
10) Confidence 0.05 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18180106 Disease Relevance 1.41 Pain Relevance 1.00
Induced cells with Neuronal Progenitor Basal Medium (NPBM medium) or Neurobasal added with a mix cytokines, demonstrate an increased expression of Tyrosine Hydroxylase (TH), MAP-2, NF, NeuN, GABA, nestin and GFAP [14,16].
Positive_regulation (increased) of Gene_expression (expression) of GABA in Neuronal associated with gaba and cytokine
11) Confidence 0.04 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.07 Pain Relevance 0.17
In the human brain, VPA alters the activity of the neurotransmitter Gamma Amino Butyrate (GABA) by potentialising the inhibitory activity of GABA through several mechanisms, including inhibition of GABA degradation, inhibition of GABA Transaminobutyratre (ABAT), increased GABA synthesis, and decreased turnover [5].
Positive_regulation (increased) of Gene_expression (synthesis) of GABA in brain associated with gaba and neurotransmitter
12) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.65 Pain Relevance 0.48
-aminobutyric acid (GABA)ergic functions in some specific brain regions that are thought to be involved in the control of seizure generation and propagation by increasing both GABA synthesis and release [8].
Positive_regulation (increasing) of Gene_expression (synthesis) of GABA in brain associated with gaba and convulsion
13) Confidence 0.03 Published 2005 Journal Crit Care Section Body Doc Link PMC1297603 Disease Relevance 1.25 Pain Relevance 0.26
In the human brain, VPA alters the activity of the neurotransmitter Gamma Amino Butyrate (GABA) by potentialising the inhibitory activity of GABA through several mechanisms, including inhibition of GABA degradation, inhibition of GABA Transaminobutyratre (ABAT), increased GABA synthesis, and decreased turnover [5].
Positive_regulation (increased) of Gene_expression (synthesis) of GABA in brain associated with gaba and neurotransmitter
14) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.65 Pain Relevance 0.48

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