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Context Info
Confidence 0.03
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6, GRHPR) oxidoreductase activity (GRHPR) endoplasmic reticulum (CYP2B6)
cellular nitrogen compound metabolic process (GRHPR) cytoplasm (GRHPR)
Anatomy Link Frequency
1A2 1
CYP2B6 (Homo sapiens)
GRHPR (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 7 90.80 High High
Disease Link Frequency Relevance Heat
Aging 1 52.88 Quite High
Hypoxia 1 51.52 Quite High
Arrhythmias 2 Under Development 1 29.52 Quite Low
Heart Rate Under Development 1 27.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because R-warfarin is a weak inhibitor of vitamin K epoxide reductase and is metabolized by cytochrome P450 (CYP) 1A2 and 3A4, it is hypothesized that simultaneous competition with R-warfarin for CYP1A2 and 3A4 is required for drug interactions to be clinically significant with compounds exclusively affecting the R enantiomer, such as acetaminophen.
P450 Binding (metabolized) of reductase in 1A2 associated with paracetamol
1) Confidence 0.03 Published 2000 Journal Pharmacotherapy Section Abstract Doc Link 11130219 Disease Relevance 0.10 Pain Relevance 0.47

General Comments

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