INT92814

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Context Info
Confidence 0.51
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 20.67
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
endothelial cells 2
osteoblasts 1
odontoblasts 1
endothelium 1
limb 1
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 14 99.64 Very High Very High Very High
ischemia 42 99.40 Very High Very High Very High
metalloproteinase 17 97.52 Very High Very High Very High
bradykinin 64 97.16 Very High Very High Very High
agonist 9 95.16 Very High Very High Very High
Glutamate 18 95.00 High High
cytokine 42 93.16 High High
Inflammation 138 92.76 High High
pulpitis 4 90.68 High High
cva 101 89.36 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 18 99.64 Very High Very High Very High
Spasticity 5 99.50 Very High Very High Very High
Cv Unclassified Under Development 33 99.40 Very High Very High Very High
Coronary Artery Disease 57 99.26 Very High Very High Very High
Stress 112 99.08 Very High Very High Very High
Diabetes Mellitus 322 98.94 Very High Very High Very High
Disease 102 98.92 Very High Very High Very High
Targeted Disruption 23 98.92 Very High Very High Very High
Prediabetic State 66 98.74 Very High Very High Very High
Metabolic Syndrome 86 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism by which the Asp298 variant could decrease the eNOS activity remains unclear.
Negative_regulation (decrease) of eNOS
1) Confidence 0.51 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.43 Pain Relevance 0.03
In vitro studies have suggested that the Asp298 variant may be functional and associated with a decreased of eNOS activity [10].
Negative_regulation (decreased) of eNOS
2) Confidence 0.51 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.42 Pain Relevance 0.09
According to the luciferase reporter gene assays performed by Nakayama et al. (23), this mutation reduces eNOS promoter activity and finally causes a reduction in NO levels.
Negative_regulation (reduces) of eNOS
3) Confidence 0.43 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2722006 Disease Relevance 0.78 Pain Relevance 0.19
Experimental studies support an important role for eNOS in the regulation of angiogenesis [4]: mice lacking eNOS gene have severely reduced angiogenesis in response to tissue ischemia [5,6] while eNOS overexpression enhances angiogenesis [7-9].
Negative_regulation (lacking) of eNOS associated with ischemia
4) Confidence 0.42 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.58 Pain Relevance 0.15
We have localized the eNOS and iNOS by immunohistochemistry and have tested their mRNA expression by RT-PCR and protein levels by Western blots. eNOS is present in the endothelial cells and odontoblasts of the healthy pulp, but an elevation of eNOS mRNA and protein levels with a concomitant dilation of vessels was characteristic under pathological conditions.
Negative_regulation (elevation) of eNOS in endothelial cells
5) Confidence 0.41 Published 2004 Journal J. Dent. Res. Section Abstract Doc Link 15044505 Disease Relevance 0.26 Pain Relevance 0.21
If there is a complete loss of eNOS enzyme as in the eNOS -/- knockout mouse model of Duplain and Sherrer [20] insulin resistance, hypertension, and hyperlipidemia develop.
Negative_regulation (loss) of eNOS associated with targeted disruption, hypertension, hyperlipidemia and insulin resistance
6) Confidence 0.39 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.35 Pain Relevance 0.05
eNOS may be impaired by abnormal structure and or function that occurs in gene polymorphisms.
Negative_regulation (impaired) of eNOS
7) Confidence 0.39 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.34 Pain Relevance 0.11
In the present study, we hypothesized that a genetic-mediated decreased eNOS activity may limit collateral development in patients with chronic coronary occlusions.
Negative_regulation (decreased) of eNOS associated with coronary heart disease
8) Confidence 0.37 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.39 Pain Relevance 0.08
We hypothesized that a genetic-mediated decreased eNOS activity may limit collateral development in patients with chronic coronary occlusions.


Negative_regulation (decreased) of eNOS associated with coronary heart disease
9) Confidence 0.37 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1239913 Disease Relevance 0.26 Pain Relevance 0.05
Murohara et al. demonstrated that angiogenesis developing in response to limb ischemia was severely reduced in mice lacking eNOS gene [5].
Negative_regulation (lacking) of eNOS in limb associated with ischemia
10) Confidence 0.37 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.48 Pain Relevance 0.13
This gene polymorphism could interact with the environment to produce an even more defective eNOS enzyme with increasing endothelial cell dysfunction.
Negative_regulation (defective) of eNOS in endothelial cell
11) Confidence 0.34 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.51 Pain Relevance 0
Redox stress and ROS are elevated in the preexisting (un-remodeled) arteriolar endothelial milieu in MS, PD, and T2DM and is associated with endothelial dysfunction with decreased eNOS activity and decreased generation of eNO.
Negative_regulation (decreased) of eNOS associated with stress, diabetes mellitus, prediabetic state and metabolic syndrome
12) Confidence 0.32 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.74 Pain Relevance 0.17
is known to decrease eNOS mRNA levels by increasing the rate of mRNA degradation [18,19].
Negative_regulation (decrease) of eNOS
13) Confidence 0.27 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 1.23 Pain Relevance 0.33
Thus, the impairment in eNOS and eNO (due to redox stress and ROS) [8] could impair the initiation and progression of arteriogenesis and result in a negative effect on remodeling collateralization.
Negative_regulation (impairment) of eNOS associated with stress
14) Confidence 0.27 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC356925 Disease Relevance 1.56 Pain Relevance 0.12
LPS also significantly increased mRNA of iNOS, protein level of NF-kappaB and decreased mRNA of eNOS (P < 0.05).
Negative_regulation (decreased) of eNOS
15) Confidence 0.25 Published 2006 Journal Inflamm. Res. Section Body Doc Link 17122960 Disease Relevance 0 Pain Relevance 0
Schiessl on the other hand, found no differences in immunohistochemical expression of eNOS in the syncytiotrophoblast and extravillous trophoblast of placentas of normal controls and preeclamptic mothers, although placentas with IUGR show a decreased immunoreactivity and eNOS protein content, as estimated by Western blotting[119].
Negative_regulation (decreased) of eNOS in placentas
16) Confidence 0.22 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.24 Pain Relevance 0
When HTB-11 cells were treated with L-NAME, a cNOS inhibitor; the effects of morphine were blocked.
Negative_regulation (inhibitor) of cNOS
17) Confidence 0.22 Published 2005 Journal Med. Sci. Monit. Section Body Doc Link 16192893 Disease Relevance 0.14 Pain Relevance 0
leptin-induced ECs migration through inhibition of Akt and eNOS signaling [84].
Negative_regulation (inhibition) of eNOS
18) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.31 Pain Relevance 0.03
The defective eNOS-driven NO synthesis causes insulin
Negative_regulation (defective) of eNOS
19) Confidence 0.20 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.49 Pain Relevance 0.03
In studies with human osteoblasts, however, eNOS inhibition did not prevent the action of statins on bone formation [48,49,13].
Negative_regulation (inhibition) of eNOS in osteoblasts
20) Confidence 0.16 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.32 Pain Relevance 0

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