INT9282

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 48
Total Number 51
Disease Relevance 12.15
Pain Relevance 22.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1B) cytoplasm (HTR1B) signal transducer activity (HTR1B)
Anatomy Link Frequency
caudate putamen 2
medial 2
plasma 1
striatum 1
brain 1
HTR1B (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 122 100.00 Very High Very High Very High
Serotonin 73 100.00 Very High Very High Very High
Neuropeptide 9 100.00 Very High Very High Very High
Substantia nigra 8 100.00 Very High Very High Very High
Sumatriptan 177 99.88 Very High Very High Very High
adenocard 8 99.72 Very High Very High Very High
cerebral cortex 4 99.68 Very High Very High Very High
5HT 564 99.46 Very High Very High Very High
Periaqueductal grey 4 99.44 Very High Very High Very High
Migraine 85 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cluster Headache 6 100.00 Very High Very High Very High
Glioma 47 99.86 Very High Very High Very High
Increased Venous Pressure Under Development 21 99.82 Very High Very High Very High
Atherosclerosis 4 99.44 Very High Very High Very High
Headache 99 99.38 Very High Very High Very High
Aging 5 98.34 Very High Very High Very High
Pain 37 98.08 Very High Very High Very High
Nociception 5 98.00 Very High Very High Very High
Depression 57 97.52 Very High Very High Very High
Coronary Artery Disease 2 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the Ca2+-dependent K+ channel blockers iberiotoxin (0.1 microM) and tetraethylammonium (TEA, 1 mM) abolished sumatriptan-induced increases in IK (-0.5+/-1.0%, n=4 and -3.9+/-3.1%, n=4, respectively, P=NS in each case) in C6 cells expressing h 5-HT1B receptors, confirming the involvement of Ca2+-dependent K+ channels.
Gene_expression (expressing) of 5-HT1B associated with sumatriptan
1) Confidence 0.75 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9879718 Disease Relevance 0.14 Pain Relevance 0.46
Outward K+ currents (IK) were examined in nontransfected C6 glioma cells and in cells expressing cloned h 5-HT1B or h 5-HT1D receptors using the patch-clamp technique in the whole-cell configuration.
Gene_expression (expressing) of 5-HT1B associated with glioma
2) Confidence 0.75 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9879718 Disease Relevance 0.36 Pain Relevance 0.14
In C6 cells expressing cloned h 5-HT1B receptors, sumatriptan (1 microM) similarly failed to significantly increase IK in the presence of dibutyryl cAMP (10 microM) or when a nominally Ca2+-free medium was included in the patch pipette (-19.4+/-5.1%, n=5 and -5.2+/-4.3%, n=5, respectively, P=NS in each case).
Gene_expression (expressing) of 5-HT1B associated with sumatriptan
3) Confidence 0.75 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9879718 Disease Relevance 0.07 Pain Relevance 0.59
Studies from ours and other laboratories have shown that 5-HT1B receptors are densely expressed in the ventral pallidum, globus pallidus, substantia nigra and dorsal subiculum and moderately expressed in the cerebral cortex, the molecular layer of the hippocampus, the entopeduncular nucleus, the superficial gray layer of the superior colliculus, the caudate putamen and the deep nuclei of the cerebellum.
Gene_expression (expressed) of 5-HT1B in caudate putamen associated with substantia nigra, hippocampus and cerebral cortex
4) Confidence 0.75 Published 2004 Journal Neurosci Biobehav Rev Section Abstract Doc Link 15527863 Disease Relevance 0 Pain Relevance 0.33
The putative coupling between stably expressed recombinant h 5-HT1B or h 5-HT1D receptors and K+ channels which regulate excitability was investigated in C6 glioma cells.
Gene_expression (expressed) of 5-HT1B associated with glioma
5) Confidence 0.75 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9879718 Disease Relevance 0.33 Pain Relevance 0.06
In the presence of the mixed 5-HT1B/D receptor antagonist GR 127935 (0.1 microM), sumatriptan (1 microM) failed to significantly increase IK in C6 cells expressing h 5-HT1B receptors (-7.5+/-3.5%, P=NS, n=6), although a higher concentration of GR 127935 (1 microM) was required to significantly inhibit sumatriptan-evoked increases in IK in C6 cells expressing h 5-HT1D receptors (-1.8+/-3.5%, P=NS, n=6), confirming that sumatriptan-evoked responses were indeed mediated by h 5-HT1B and h 5-HT1D receptors, respectively.
Gene_expression (expressing) of 5-HT1B associated with sumatriptan and antagonist
6) Confidence 0.75 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9879718 Disease Relevance 0.27 Pain Relevance 0.56
Kinetic studies comparing the binding of [3H]eletriptan and [3H]sumatriptan to the human recombinant 5-HT1B and 5-HT1D receptors expressed in HeLa cells revealed that both radioligands bound with high specificity (>90%) and reached equilibrium within 10-15 min.
Gene_expression (expressed) of 5-HT1B in HeLa associated with sumatriptan
7) Confidence 0.75 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10193663 Disease Relevance 0.09 Pain Relevance 0.48
Studies from ours and other laboratories have shown that 5-HT1B receptors are densely expressed in the ventral pallidum, globus pallidus, substantia nigra and dorsal subiculum and moderately expressed in the cerebral cortex, the molecular layer of the hippocampus, the entopeduncular nucleus, the superficial gray layer of the superior colliculus, the caudate putamen and the deep nuclei of the cerebellum.
Gene_expression (expressed) of 5-HT1B in caudate putamen associated with substantia nigra, hippocampus and cerebral cortex
8) Confidence 0.75 Published 2004 Journal Neurosci Biobehav Rev Section Abstract Doc Link 15527863 Disease Relevance 0 Pain Relevance 0.35
We analyzed the expression of three types of serotonin receptors: 5-HT1B, 5-HT2C and 5-HT1D by reverse transcription-polymerase chain reaction in mouse unfertilized oocytes and preimplantation embryos from zygotes to the blastocyst stage in vivo.
Spec (analyzed) Gene_expression (expression) of 5-HT1B in zygotes associated with serotonin
9) Confidence 0.75 Published 2003 Journal Physiol Res Section Abstract Doc Link 12678665 Disease Relevance 0 Pain Relevance 0.38
In C6 cells expressing human 5-HT1B or human 5-HT1D receptors, F 11356 was the most potent compound in inhibiting forskolin-induced cyclic AMP formation (pD2 = 8.9 and 9.6), and in contrast to tryptamine and derivatives, it produced maximal enhancement of [35S]guanosine-5'-O-(3-thio)triphosphate-specific binding equivalent to 5-HT.
Gene_expression (expressing) of 5-HT1B
10) Confidence 0.75 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10381763 Disease Relevance 0.14 Pain Relevance 0.15
The 'triptan' anti-migraine agents (e.g. sumatriptan, rizatriptan, zolmitriptan naratriptan) are serotonergic agonists that have been shown to act selectively by causing vasoconstriction through 5-HT1B receptors that are expressed in human intracranial arteries and by inhibiting nociceptive transmission through an action at 5-HT1D receptors on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brain stem sensory nuclei.
Gene_expression (expressed) of 5-HT1B in meninges associated with nociception, sumatriptan, migraine, agonist, triptan and increased venous pressure under development
11) Confidence 0.75 Published 1999 Journal Can J Neurol Sci Section Abstract Doc Link 10563228 Disease Relevance 1.35 Pain Relevance 1.54
Thus, the sumatriptan-induced vasospasm which occurs at low incidence as a side-effect in migraine therapy may be related to the expression of the (124-Cys)h5-HT1B receptor in patients with additional pathogenetic factors such as coronary heart disease.
Gene_expression (expression) of 5-HT1B in heart associated with sumatriptan, coronary artery disease, migraine and increased venous pressure under development
12) Confidence 0.75 Published 2000 Journal Pharmacogenetics Section Abstract Doc Link 11037806 Disease Relevance 0.29 Pain Relevance 0.43
In C6 cells expressing cloned h 5-HT1B receptors, sumatriptan (1 microM) similarly failed to significantly increase IK after 30-min incubation with thapsigargin (1 microM) or when heparin (2 mg/ml) was included in the patch pipette (1.1+/-0.4%, n=5 and 1.2+/-2.4%, n=5, respectively, P=NS).
Gene_expression (expressing) of 5-HT1B associated with sumatriptan
13) Confidence 0.75 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9879718 Disease Relevance 0.15 Pain Relevance 0.45
In C6 cells expressing either cloned h 5-HT1B or h 5-HT1D receptors, sumatriptan-induced increases in IK were prevented by the calcium chelator EGTA (5 mM) when included in the patch pipette (maximum increase 0.57+/-0.6%, n=3, P=NS and -2.8+/-1.6%, n=5, P=NS, respectively).
Gene_expression (expressing) of 5-HT1B associated with sumatriptan
14) Confidence 0.75 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9879718 Disease Relevance 0.13 Pain Relevance 0.62
The identity of the 5-HT1B binding sites under these conditions was corroborated by the pIC50 of sumatriptan, which corresponded to its affinity for cloned human 5-HT1B receptors expressed in cells.
Gene_expression (expressed) of 5-HT1B associated with sumatriptan
15) Confidence 0.75 Published 1997 Journal Recept. Channels Section Abstract Doc Link 9606727 Disease Relevance 0 Pain Relevance 0.24
METHODS: Rings of arteries, coexpressing 5-HT1B and 5-HT2A receptors, from 98 patients undergoing neurosurgery were set up to measure contraction.
Gene_expression (coexpressing) of 5-HT1B
16) Confidence 0.75 Published 2006 Journal Pharmacogenet. Genomics Section Body Doc Link 16847428 Disease Relevance 0 Pain Relevance 0
Isolated microvessels and capillaries consistently expressed messages for the h5-HT1B, h5-HT1D, 5-HT1F, 5-HT2A but not 5-HT7 receptors.
Gene_expression (expressed) of 5-HT1B
17) Confidence 0.75 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10458598 Disease Relevance 0 Pain Relevance 0
These findings clearly show the significance of 5-HT1B receptor expression level in determining whether 5-HT1B receptor activation can modulate the accumulation of [3H]inositol phosphates elicited by a Gq-protein coupled receptor.
Gene_expression (expression) of 5-HT1B
18) Confidence 0.75 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652344 Disease Relevance 0.18 Pain Relevance 0.33
RESULTS: Three patients exhibited the Cys/Phe genotype, probably yielding coexpression of both the 124Phe and the 124Cys 5-HT1B receptors.
Spec (probably) Gene_expression (coexpression) of 5-HT1B
19) Confidence 0.75 Published 2006 Journal Pharmacogenet. Genomics Section Body Doc Link 16847428 Disease Relevance 0 Pain Relevance 0
We also examined the expression of 5-HT1B receptors in atherosclerotic and normal coronary arteries.
Spec (examined) Gene_expression (expression) of 5-HT1B associated with atherosclerosis
20) Confidence 0.75 Published 2005 Journal Clin. Sci. Section Abstract Doc Link 15853772 Disease Relevance 0.18 Pain Relevance 0.86

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