INT92821

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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 9.82
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd14) plasma membrane (Cd14) response to stress (Cd14)
Anatomy Link Frequency
monocytes 14
hepatocytes 2
leucocyte 2
B cells 2
neutrophil 2
Cd14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 13 100.00 Very High Very High Very High
MU agonist 1 99.96 Very High Very High Very High
Inflammatory response 4 99.86 Very High Very High Very High
Inflammation 48 99.72 Very High Very High Very High
cytokine 34 99.36 Very High Very High Very High
Angina 9 99.32 Very High Very High Very High
Cancer pain 49 99.12 Very High Very High Very High
substance P 1 98.96 Very High Very High Very High
opioid receptor 3 97.52 Very High Very High Very High
Potency 6 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 13 100.00 Very High Very High Very High
Magnesium Deficiency 1 99.84 Very High Very High Very High
INFLAMMATION 45 99.72 Very High Very High Very High
Bone Cancer 55 99.32 Very High Very High Very High
Cv General 3 Under Development 9 99.32 Very High Very High Very High
Acute Coronary Syndrome 8 99.28 Very High Very High Very High
Adhesions 4 97.88 Very High Very High Very High
Infection 22 97.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 21 97.32 Very High Very High Very High
Viral Meningitis 7 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to bacterial peritonitis, we observed no increase in CD14 expression on the peripheral and peritoneal macrophages on the day of presentation and during the follow-up period.
Neg (no) Positive_regulation (increase) of Gene_expression (expression) of CD14 in peritoneal macrophages
1) Confidence 0.66 Published 2003 Journal Nephrol. Dial. Transplant. Section Body Doc Link 12897108 Disease Relevance 0.16 Pain Relevance 0
Removing endogenous E2 through OVX reduced CFA induced TMJ inflammation, whereas CFA increased the number of TMJ monocytes expressing the CD14 receptor equally in all groups irrespective of plasma E2 levels.
Positive_regulation (increased) of Gene_expression (expressing) of CD14 in monocytes associated with snapping jaw and inflammation
2) Confidence 0.60 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 16153820 Disease Relevance 2.32 Pain Relevance 1.36
Flow cytometrical analysis revealed that PPF pretreatment showed no modulatory effect on the LPS-upregulated CD14 expression on hepatocytes.
Positive_regulation (upregulated) of Gene_expression (expression) of CD14 in hepatocytes
3) Confidence 0.54 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.32 Pain Relevance 0.17
Intestinal and cardiac inflammatory response shows enhanced endotoxin receptor (CD14) expression in magnesium deficiency.
Positive_regulation (enhanced) of Gene_expression (expression) of CD14 associated with inflammatory response, inflammation and magnesium deficiency
4) Confidence 0.49 Published 2005 Journal Mol. Cell. Biochem. Section Title Doc Link 16180088 Disease Relevance 0.38 Pain Relevance 0.36
Because no increase in the expression of the LPS receptor CD14 could be observed, the increased peritoneal leucocyte count is probably not caused by LPS or LPS-like (possibly peptidoglycan-like) contamination.


Neg (no) Positive_regulation (increase) of Gene_expression (expression) of CD14 in leucocyte
5) Confidence 0.44 Published 2003 Journal Nephrol. Dial. Transplant. Section Body Doc Link 12897108 Disease Relevance 0 Pain Relevance 0
The TT homozygote has been associated with increased circulating soluble CD14 levels and a higher density of the monocyte CD14 receptor [22].
Positive_regulation (increased) of Gene_expression (levels) of CD14 in monocyte
6) Confidence 0.42 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266053 Disease Relevance 0.70 Pain Relevance 0.36
A two- to three-fold increase in the mRNA expression levels of microglial activation markers CD11b and CD14 was observed in bone cancer pain rats at days 6 and 12 after inoculation (n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).
Positive_regulation (increase) of Gene_expression (expression) of CD14 associated with cancer pain and bone cancer
7) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.68 Pain Relevance 0.58
OBJECTIVES: The purpose of this study was to establish whether oxidized low-density lipoprotein (oxLDL) contributes to cytokine overproduction via upregulation of CD14 and toll-like receptor-4 (TLR-4) expression on circulating monocytes of unstable angina (UA) patients.
Spec (whether) Positive_regulation (upregulation) of Gene_expression (expression) of CD14 in monocytes associated with angina and cytokine
8) Confidence 0.24 Published 2007 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 17600225 Disease Relevance 0.17 Pain Relevance 0.26
The expression of CD14 by monocytes was increased significantly in ACS patients (activation index 38.7 +/- 2.5, mean +/- SEM) in comparison to the control subjects (8.0 +/- 1.9) and the SA patients (16.9 +/- 3.9) (p < 0.001 and p < 0.01, respectively).
Positive_regulation (increased) of Gene_expression (expression) of CD14 in monocytes associated with acute coronary syndrome and angina
9) Confidence 0.23 Published 2000 Journal Jpn Heart J Section Abstract Doc Link 11132167 Disease Relevance 1.12 Pain Relevance 0.36
M induced CD14 expression (Fig. 3).
Positive_regulation (induced) of Gene_expression (expression) of CD14
10) Confidence 0.23 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.77 Pain Relevance 0.05
We constructed a number of gene sets a priori for CD4+ T cells, CD8+ T cells, CD19+ B cells, CD14+ monocytes and CD16+ neutrophils using data collected on Affymetrix microarrays (Affymetrix, Santa Clara, CA, USA) by Lyons et al. [23].
Positive_regulation (priori) of Gene_expression (monocytes) of CD14 in B cells
11) Confidence 0.21 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.17 Pain Relevance 0.05
Indeed significant interactions appeared linking the expression of the CD14+ monocyte gene set with that of the B cell (CD19+ up-regulated) and the CD16+ neutrophil gene sets.
Positive_regulation (linking) of Gene_expression (expression) of CD14 in neutrophil
12) Confidence 0.21 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.47 Pain Relevance 0
METHODS: We studied changes in adhesion molecule expression of platelets (GPIIb/IIIa), neutrophils--CD18, CD11b and L-selectin--and monocytes (CD14) after interaction with active lesions of patients with stable angina subjected to PTCA and patients with unstable angina (UA).
Positive_regulation (changes) of Gene_expression (expression) of CD14 in monocytes
13) Confidence 0.16 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 15771923 Disease Relevance 0.19 Pain Relevance 0
CONCLUSIONS: In UA patients oxLDL may contribute to monocyte overproduction of some cytokines by upregulating CD14 and TLR-4 expression.


Positive_regulation (upregulating) of Gene_expression (expression) of CD14 in monocyte
14) Confidence 0.16 Published 2007 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 17600225 Disease Relevance 0.06 Pain Relevance 0
CD14 expression was restricted to perivascular microglia in all groups (including normal controls) apart from the two HIVE groups where some but not all cases also showed parenchymal expression of CD14.
Positive_regulation (restricted) of Gene_expression (expression) of CD14 in microglia associated with viral meningitis
15) Confidence 0.14 Published 2005 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 15885069 Disease Relevance 1.33 Pain Relevance 0.11
Our results show that DAMGO, a selective mu-opioid agonist, increases CXCR4 and CCR5 expression in both CD3(+) lymphoblasts and CD14(+) monocytes three- to fivefold.
Positive_regulation (increases) of Gene_expression (expression) of CD14 in monocytes associated with mu agonist
16) Confidence 0.06 Published 2003 Journal Virology Section Abstract Doc Link 12726730 Disease Relevance 0.96 Pain Relevance 0.83

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