INT92823

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Context Info
Confidence 0.68
First Reported 2000
Last Reported 2010
Negated 5
Speculated 5
Reported most in Abstract
Documents 65
Total Number 70
Disease Relevance 25.69
Pain Relevance 14.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP1) extracellular region (MMP1) proteinaceous extracellular matrix (MMP1)
Anatomy Link Frequency
fibroblasts 24
keratinocytes 8
chondrocytes 4
joints 4
skin 4
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 589 100.00 Very High Very High Very High
cytokine 211 100.00 Very High Very High Very High
Inflammatory stimuli 10 99.98 Very High Very High Very High
agonist 26 99.96 Very High Very High Very High
qutenza 34 99.62 Very High Very High Very High
endometriosis 276 99.28 Very High Very High Very High
Angina 49 98.52 Very High Very High Very High
Osteoarthritis 431 98.38 Very High Very High Very High
rheumatoid arthritis 214 98.20 Very High Very High Very High
Arthritis 62 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Endometriosis 362 100.00 Very High Very High Very High
Shock 113 100.00 Very High Very High Very High
INFLAMMATION 312 99.82 Very High Very High Very High
Death 178 99.66 Very High Very High Very High
Transitional Cell Carcinoma 26 98.92 Very High Very High Very High
Sprains And Strains 29 98.78 Very High Very High Very High
Cv General 3 Under Development 13 98.52 Very High Very High Very High
Osteoarthritis 390 98.38 Very High Very High Very High
Rheumatoid Arthritis 214 98.20 Very High Very High Very High
Arthritis 91 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: In general, median expression of MMP-1 in the ulcer tissue was significantly increased compared to the surrounding mucosa (16.8 [4.7-33.4] vs. 10.9 [2.8-17.8] ng/mg protein) (p < 0.001).
Positive_regulation (increased) of Gene_expression (expression) of MMP-1
1) Confidence 0.68 Published 2000 Journal Z Gastroenterol Section Body Doc Link 11132534 Disease Relevance 0.16 Pain Relevance 0
Even with an extreme single irradiation dose of 3951 J/cm² (which would mean an irradiance of 1098 mW/cm², if administered during 1 hour; an irradiance is not presented) Kim et al. [53] found no increase of MMP-1 mRNA expression after single infrared irradiation, but only after multiple irradiations.
Neg (no) Positive_regulation (increase) of Gene_expression (expression) of MMP-1 mRNA
2) Confidence 0.66 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.09 Pain Relevance 0
Taking these aspects into account, the present study evidences no systematic induction of MMP-1 mRNA expression or other undesired effects with high or even disproportionally high irradiances and irradiation doses of wIRA in skin fibroblast cultures, supporting the notion that wIRA does not bring along noxious consequences when clinically administered in an appropriate form.
Positive_regulation (induction) of Gene_expression (expression) of MMP-1 mRNA in skin
3) Confidence 0.66 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.07 Pain Relevance 0
Conclusions: wIRA(+RL) even at the investigated disproportionally high irradiances does not induce cell death or a systematic increase of MMP-1 mRNA expression, both of which can be easily induced by UV-A radiation.
Positive_regulation (increase) of Gene_expression (expression) of MMP-1 mRNA associated with death
4) Confidence 0.66 Published 2007 Journal GMS German Medical Science Section Abstract Doc Link PMC2703241 Disease Relevance 0.26 Pain Relevance 0.03
Taken together, our results suggest that heat-shock-induced MMP-1 expression is mediated by activation of TRPV1 and is dependent on a calcium-dependent signaling process in human epidermal keratinocytes.
Positive_regulation (induced) of Gene_expression (expression) of MMP-1 in keratinocytes associated with shock and metalloproteinase
5) Confidence 0.55 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.66 Pain Relevance 0.50
Heat shock induced the expression of MMP-1 mRNA and protein in a temperature-dependent manner in an immortalized human keratinocyte cell line (HaCaT) and normal human epidermal keratinocytes (NHK).
Positive_regulation (induced) of Gene_expression (expression) of MMP-1 in keratinocyte associated with shock and metalloproteinase
6) Confidence 0.55 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.49 Pain Relevance 0.38
We found that heat shock induced calcium influx through TRPV1 and that extracellular calcium was necessary for heat-shock-induced MMP-1 expression in HaCaT cells.
Positive_regulation (induced) of Gene_expression (expression) of MMP-1 associated with shock and metalloproteinase
7) Confidence 0.55 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.68 Pain Relevance 0.51
We found that heat shock induced calcium influx through TRPV1 and that extracellular calcium was necessary for heat-shock-induced MMP-1 expression in HaCaT cells.
Positive_regulation (necessary) of Gene_expression (expression) of MMP-1 associated with shock and metalloproteinase
8) Confidence 0.55 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.68 Pain Relevance 0.52
Overexpression and activation of MMPs contributes to many pathologies, including arthritis, cardiovascular disease, tumour progression and lung disease.
Positive_regulation (activation) of Gene_expression (Overexpression) of MMP in lung associated with pulmonary disease, cancer, cardiovascular disease, metalloproteinase and arthritis
9) Confidence 0.49 Published 2005 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 16101546 Disease Relevance 1.03 Pain Relevance 0.56
Overexpression and activation of MMPs contributes to many pathologies, including arthritis, cardiovascular disease, tumour progression and lung disease.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of MMP in lung associated with pulmonary disease, cancer, cardiovascular disease, metalloproteinase and arthritis
10) Confidence 0.49 Published 2005 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 16101546 Disease Relevance 1.03 Pain Relevance 0.56
Heat-shock-induced MMP-1 expression was decreased by treatment of the TRPV1 inhibitors (capsazepine and ruthenium red) or knockdown of TRPV1 using RNA interference in HaCaT cells.
Positive_regulation (induced) of Gene_expression (expression) of MMP-1 associated with shock and metalloproteinase
11) Confidence 0.48 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.63 Pain Relevance 0.47
Conclusions: wIRA(+RL) even at the investigated disproportionally high irradiances does not induce cell death or a systematic increase of MMP-1 mRNA expression, both of which can be easily induced by UV-A radiation.
Positive_regulation (induced) of Gene_expression (expression) of MMP-1 mRNA associated with death
12) Confidence 0.48 Published 2007 Journal GMS German Medical Science Section Abstract Doc Link PMC2703241 Disease Relevance 0.26 Pain Relevance 0.03
These studies have shown that high strains (or long duty cycles) applied by stretching bioreactors can cause tenocytes to produce abnormal levels of matrix metalloproteases (MMPs), which would in turn degrade the collagen and cause degeneration [131,137-144].
Positive_regulation (cause) of Gene_expression (produce) of MMP associated with sprains and strains
13) Confidence 0.45 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2695438 Disease Relevance 0.93 Pain Relevance 0.08
Remarkably, several MMP genes (MMP1,2,3,10,11,14) were found overexpressed and specific for endometriosis, possibly providing a biological explanation for the propensity of these cells to invade the surrounding tissues.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MMP1 associated with endometriosis
14) Confidence 0.45 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.28 Pain Relevance 0.37
There was a clear induction of MMP-1 expression in fibroblasts irradiated with UV-A(+BL), with a 76 ±2 fold expression (at 30°C) and a 75 ±1 fold expression (at 37°C) related to basal levels normalized to actin mRNA expression (see Figure 4 and Figure 5).


Spec (clear) Positive_regulation (induction) of Gene_expression (expression) of MMP-1 in fibroblasts
15) Confidence 0.44 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0 Pain Relevance 0
In the present study we showed (i) that single wIRA exposure neither caused cell death nor MMP-1 mRNA up-regulation in skin fibroblasts at two physiologic temperatures (30°C and 37°C), and (ii) that the same was true for repeated wIRA exposure at 30°C, while (iii) UV-A radiation (mainly UV-A1) caused a drastic increase in MMP-1 mRNA expression under all investigated conditions (11 ±1 fold expression for conventional RT-PCR and 76 ±2 fold expression for quantitative real-time RT-PCR both at 30°C in single exposure, and 75 ±1 fold expression for quantitative real-time RT-PCR at 37°C in single exposure) and a dose-dependent decrease in cell survival.
Spec (investigated) Positive_regulation (increase) of Spec (investigated) Gene_expression (expression) of MMP-1 mRNA in fibroblasts associated with death
16) Confidence 0.44 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.10 Pain Relevance 0
wIRA(+RL) irradiation was employed at multiple irradiation doses to dermal fibroblasts at 30°C and in addition at 37°C to obtain a potential induction of MMP-1 mRNA expression.
Positive_regulation (induction) of Gene_expression (expression) of MMP-1 mRNA in fibroblasts
17) Confidence 0.44 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0 Pain Relevance 0
On the molecular level, a recent publication has indicated that wIRA irradiation could induce MMP-1 gene expression in newborn foreskin dermal fibroblasts using conventional RT-PCR techniques (RT-PCR) [44] (and derived from this [47], [48], [49]).
Positive_regulation (induce) of Gene_expression (expression) of MMP-1 in fibroblasts
18) Confidence 0.44 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.06 Pain Relevance 0
UV-A(+BL) radiation (50 J/cm² at 30°C) induced MMP-1 mRNA expression and when normalized to actin mRNA expression showed a 11 ±1 fold expression compared with fibroblasts that were not irradiated (see Figure 3).
Positive_regulation (induced) of Gene_expression (expression) of MMP-1 mRNA in fibroblasts
19) Confidence 0.44 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.24 Pain Relevance 0
Additionally, repeated exposure of human skin fibroblasts to wIRA(+RL) did not induce MMP-1 mRNA expression systematically (less than twofold expression by up to 10 consecutive wIRA(+RL) exposures and analysis with real-time RT-PCR).
Positive_regulation (induce) of Gene_expression (expression) of MMP-1 mRNA in skin
20) Confidence 0.44 Published 2007 Journal GMS German Medical Science Section Abstract Doc Link PMC2703241 Disease Relevance 0.23 Pain Relevance 0

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