INT92826

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.58
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Esrrb)
Anatomy Link Frequency
myometrium 1
autonomic 1
Esrrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dismenorea 8 99.84 Very High Very High Very High
Angina 1 93.04 High High
tolerance 3 90.96 High High
agonist 1 90.76 High High
Endogenous opioid 1 86.88 High High
Pain 1 85.60 High High
Opioid 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Dysmenorrhea 8 99.84 Very High Very High Very High
Menopausal Vasomotor Symptoms 1 99.32 Very High Very High Very High
Hyperplasia 2 97.76 Very High Very High Very High
Cv General 3 Under Development 1 93.04 High High
Anxiety Disorder 1 90.24 High High
Reprotox - General 3 5 88.88 High High
Pain 1 85.60 High High
Cancer 1 71.28 Quite High
Addisons Disease 1 24.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A correlation of steroid hormone receptor expression in AM foci and in leiomyocytes of perifocal myometrium hyperplasia was also found.
Gene_expression (expression) of steroid hormone receptor in myometrium associated with dismenorea and hyperplasia
1) Confidence 0.75 Published 2005 Journal Arkh. Patol. Section Abstract Doc Link 16075610 Disease Relevance 1.14 Pain Relevance 0.71
OBJECTIVE: The natural selective estrogen receptor modulator DT56a (Femarelle), derived from soybean, has been shown to relieve menopausal vasomotor symptoms with no effect on sex steroid hormone levels or endometrial thickness.The purpose of the present study was to evaluate the neuroendocrine effect of DT56a administration through the evaluation of brain content of allopregnanolone (AP), an endogenous neurosteroid gamma-aminobutyric acid agonist with anxiolytic properties, and through the assessment of beta-endorphin (beta-END), the endogenous opioid implicated in pain mechanism, emotional state, and autonomic control.
Gene_expression (levels) of steroid hormone in autonomic associated with pain, anxiety disorder, endogenous opioid, agonist and menopausal vasomotor symptoms
2) Confidence 0.08 Published 2009 Journal Menopause Section Abstract Doc Link 19295450 Disease Relevance 0.28 Pain Relevance 0.29
Decreased steroid hormone synthesis from inorganic nitrite and nitrate: studies in vitro and in vivo.
Gene_expression (synthesis) of steroid hormone
3) Confidence 0.02 Published 2000 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 11133344 Disease Relevance 0.16 Pain Relevance 0.18

General Comments

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