INT92835

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 13.50
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col4a1) proteinaceous extracellular matrix (Col4a1)
Anatomy Link Frequency
fibroblasts 4
lymphocytes 2
RAW 264 2
stroma 1
macrophages 1
Col4a1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 14 100.00 Very High Very High Very High
fibrosis 125 98.64 Very High Very High Very High
Inflammatory mediators 16 96.52 Very High Very High Very High
lidocaine 9 92.28 High High
metalloproteinase 142 90.56 High High
Inflammation 194 86.04 High High
Inflammatory response 8 81.04 Quite High
cytokine 88 80.00 Quite High
cINOD 17 72.56 Quite High
Inflammatory stimuli 1 68.12 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 59 99.84 Very High Very High Very High
Systemic Sclerosis 335 99.36 Very High Very High Very High
Syndrome 65 99.08 Very High Very High Very High
Fibrosis 116 98.64 Very High Very High Very High
Adhesions 232 97.40 Very High Very High Very High
Disease 86 97.14 Very High Very High Very High
INFLAMMATION 225 96.12 Very High Very High Very High
Stress 24 94.40 High High
Myeloid Leukemia 4 93.36 High High
Open-angle Glaucoma 17 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We confirmed significantly lower transcript levels of Col1a1, Col1a2, Col3a1 and Col4a1 in aged stroma by qRT-PCR (Figure 5A).
Gene_expression (levels) of Col4a1 in stroma
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.43 Pain Relevance 0.08
In contrast, COX-2 was not expressed by vector only controls or RAW clones 6, 8 and 22 but COX-2 mRNA and protein was induced in the RAW clone expressing the greatest amount of IDO (clone 11) (Fig 8A).
Gene_expression (expressing) of RAW
2) Confidence 0.32 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0.03
Therefore we treated vector-only transfected RAW cells with various concentrations of indomethacin ranging from 0.1 ?
Gene_expression (transfected) of RAW
3) Confidence 0.28 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
We transfected the murine macrophage cell line RAW 264.7 with a construct in which IDO was expressed under the control of the murine MHC Class II promoter (Fig 1A).
Gene_expression (transfected) of RAW in RAW 264
4) Confidence 0.28 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.40 Pain Relevance 0.08
Expression of iNOS mRNA in harvested RAW 264 was quantified by Northern blot analysis using mouse iNOS complementary DNA probe.
Gene_expression (Expression) of RAW in RAW 264
5) Confidence 0.28 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133614 Disease Relevance 0.38 Pain Relevance 0.61
Treatment of IDO-expressing RAW clones with a known inducer of COX-2 (LPS), revealed a lack of correlation between COX-2 RNA and protein levels.
Gene_expression (clones) of RAW
6) Confidence 0.24 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.28 Pain Relevance 0.15
Therefore, we treated IDO transfected RAW cells and controls with LPS and measured COX-2 expression 24 hours later.
Gene_expression (transfected) of RAW
7) Confidence 0.24 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
Specifically, overexpression of IDO in RAW and MC57 cells resulted in the growth of macroscopic foci and other phenotypic alterations.
Gene_expression (overexpression) of RAW
8) Confidence 0.24 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.14 Pain Relevance 0
The alterations in COX-2 expression observed in IDO-expressing RAW and MC57 cells are a particularly interesting feature of our results.
Gene_expression (expression) of RAW
9) Confidence 0.24 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.15 Pain Relevance 0.10
RAW transfectants over-expressing IDO showed reduced expression of collagenase I (MMP-1), and also bound less well to collagen-coated plates than controls.
Gene_expression (transfectants) of RAW
10) Confidence 0.24 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.16 Pain Relevance 0.04
Recent immunohistological studies in NPS patients with severe glomerular disease suggest a possible regulation of type III collagen by LMX1B, while the homozygous mutations of LMX1B do not appear to dramatically affect the expression of type IV collagen chains and podocin in NPS patients.
Gene_expression (expression) of type IV collagen associated with syndrome and disease
11) Confidence 0.14 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 1.30 Pain Relevance 0
The excessive production of type IV collagen and subsequent autoimmune T-cell responses to type IV collagen may set off a self-perpetuating cycle in SSc through the interaction between lymphocytes and fibroblasts.
Gene_expression (production) of type IV collagen in lymphocytes associated with systemic sclerosis
12) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.23 Pain Relevance 0.20
The excessive production of type IV collagen and subsequent autoimmune T-cell responses to type IV collagen may set off a self-perpetuating cycle in SSc through the interaction between lymphocytes and fibroblasts.
Gene_expression (production) of type IV collagen in lymphocytes associated with systemic sclerosis
13) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.16 Pain Relevance 0.19
Our study identified a large number of genes associated with the extracellular matrix (SPARC, SERPINH1/HSP47, COL1A1, COL1A2, COL4A1, MMP3, TIMP1, PRSS2, CDH3, SPP1, IL8, CTSB, LUM, CEACAM, CTHRC1, SULF1, ASPN, SPON2 and CLDN18) and chemokine activity, to be differentially expressed in gastric cancers.
Gene_expression (expressed) of COL4A1 in extracellular matrix associated with chemokine and stomach cancer
14) Confidence 0.05 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.37 Pain Relevance 0.05
The finding that the synthesis of type IV collagen, a major collagen type in basement membrane, is disproportionately increased in the dermal fibroblasts and sera of patients with SSc supports this notion [4,5].
Gene_expression (synthesis) of type IV collagen in fibroblasts associated with systemic sclerosis
15) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.28 Pain Relevance 0.11
Several studies demonstrated that in these animals the thymus exhibits enhanced deposition of extracellular matrix proteins such as fibronectin, laminin, and type IV collagen, increased chemokine contents such as CXCL12, and expression of de-adhesive molecules such as galectin-3.
Gene_expression (expression) of type IV collagen in thymus associated with chemokine
16) Confidence 0.04 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.27 Pain Relevance 0.05
They include the High Mobility Group family proteins including the prototypic HMGB1/amphoterin, members of the S100/calgranulin protein family, matrix proteins such as Collagen I and IV, A?
Gene_expression (include) of Collagen I and IV
17) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.08 Pain Relevance 0.14
We found that lipopolysaccharide (LPS) stimulation of mouse Raw 264.7 macrophages resulted in the upregulation of miR-155 and downregulation of miR-125b levels.
Gene_expression (macrophages) of Raw in macrophages
18) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 1.03 Pain Relevance 0.04
The expressions of vimentin and ECM molecules such as laminin, type I collagen, and type IV collagen were more intense in the precursor/gelatin group than the other groups after one week (Figure 4A).
Gene_expression (expressions) of type IV collagen
19) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2566587 Disease Relevance 0.44 Pain Relevance 0
Immunohistochemical findings on day 7 and 28 showed that the expression of type I collagen, type IV collagen, laminin, and vimentin were strongly positive in the transplanted gelatin hydrogels of the precursor/gelatin group while they were faint in the gelatin and fibroblast/gelatin groups.
Gene_expression (expression) of type IV collagen in fibroblast
20) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2566587 Disease Relevance 0 Pain Relevance 0

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