INT92837

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2011
Negated 6
Speculated 5
Reported most in Abstract
Documents 116
Total Number 121
Disease Relevance 59.67
Pain Relevance 31.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 27
RAW 264 15
lung 7
microglia 6
liver 5
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1540 100.00 Very High Very High Very High
cytokine 770 100.00 Very High Very High Very High
chemokine 109 100.00 Very High Very High Very High
Inflammatory mediators 79 100.00 Very High Very High Very High
COX2 41 100.00 Very High Very High Very High
excitatory amino acid 7 100.00 Very High Very High Very High
Inflammatory response 179 99.90 Very High Very High Very High
qutenza 18 99.84 Very High Very High Very High
agonist 323 99.82 Very High Very High Very High
Sciatic nerve 90 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1786 100.00 Very High Very High Very High
Cancer 344 100.00 Very High Very High Very High
Necrosis 117 100.00 Very High Very High Very High
Obesity 154 99.98 Very High Very High Very High
Targeted Disruption 305 99.96 Very High Very High Very High
Injury 301 99.90 Very High Very High Very High
Arthritis 159 99.52 Very High Very High Very High
Cv General 4 Under Development 19 99.52 Very High Very High Very High
Metastasis 35 99.48 Very High Very High Very High
Nociception 32 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The drug at any concentration failed to decrease iNOS mRNA expression in RAW 264.
Neg (failed) Negative_regulation (decrease) of Gene_expression (expression) of iNOS mRNA in RAW 264
1) Confidence 0.59 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133614 Disease Relevance 0.37 Pain Relevance 0.79
A possible mechanism of neuroprotection is inhibition of iNOS expression.
Negative_regulation (inhibition) of Gene_expression (expression) of iNOS
2) Confidence 0.59 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16861428 Disease Relevance 0.41 Pain Relevance 0.21
C. racemosa extracts also reduced iNOS protein expression and iNOS mRNA levels in a dose-dependent manner.
Negative_regulation (reduced) of Gene_expression (expression) of iNOS protein
3) Confidence 0.59 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703353 Disease Relevance 0 Pain Relevance 0
To further understand the mechanism of activity, we investigated whether the extract inhibited the expression of inducible nitric oxide synthase (iNOS), the production of nitric oxide (NO) and the expression of TNF-alpha from murine macrophage RAW 264.7 cells.
Spec (whether) Negative_regulation (inhibited) of Gene_expression (expression) of iNOS in RAW 264
4) Confidence 0.58 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17227629 Disease Relevance 0.42 Pain Relevance 0.33
These results suggest that Harpagophytum procumbens exerts anti-inflammatory and analgesic effects probably by suppressing cyclooxygenase-2 and iNOS expressions.
Negative_regulation (suppressing) of Gene_expression (expressions) of iNOS associated with inflammation and analgesic
5) Confidence 0.56 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646256 Disease Relevance 0.32 Pain Relevance 0.29
Our analysis of IR-challenged retinas revealed that gene expression of Nos2 was suppressed in the retina of ATP-liposome-treated animals relative to controls.
Negative_regulation (suppressed) of Gene_expression (expression) of Nos2 in retina
6) Confidence 0.56 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013064 Disease Relevance 1.03 Pain Relevance 0.42
The concentrations of erstressin required to activate UPR signaling and UPR gene expression are the same as those that reduce iNOS mRNA and protein expression and enzyme activity.
Negative_regulation (reduce) of Gene_expression (expression) of iNOS
7) Confidence 0.55 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.13 Pain Relevance 0
The results showed that TCCT inhibited LPS-induced NO and PGE2 production and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells more effectively than did XCCT or TWCCT.
Negative_regulation (inhibited) of Gene_expression (expression) of inducible nitric oxide synthase in RAW 264
8) Confidence 0.51 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16310993 Disease Relevance 0.76 Pain Relevance 0.26
Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia.
Negative_regulation (attenuate) of Gene_expression (expression) of inducible nitric oxide synthase in microglia associated with inflammation
9) Confidence 0.51 Published 2001 Journal Eur. J. Neurosci. Section Title Doc Link 11860491 Disease Relevance 0.49 Pain Relevance 0.11
PEA significantly reduced the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in sciatic nerves and restored carrageenan-induced reductions of PPAR-alpha in the L4-L6 dorsal root ganglia (DRG).
Negative_regulation (reduced) of Gene_expression (expression) of iNOS in dorsal root ganglia associated with sciatic nerve
10) Confidence 0.51 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.72 Pain Relevance 0.89
Although both compounds partially inhibited the catalytic activity of iNOS, their inhibitory effect was predominantly due to attenuation of iNOS protein production.
Negative_regulation (attenuation) of Gene_expression (production) of iNOS
11) Confidence 0.51 Published 2006 Journal Planta Med. Section Abstract Doc Link 16732525 Disease Relevance 0.32 Pain Relevance 0.20
Remifentanil could suppress inflammatory responses and inhibit iNOS expression in septic mice.
Negative_regulation (inhibit) of Gene_expression (expression) of iNOS associated with inflammatory response and ultiva
12) Confidence 0.48 Published 2010 Journal Mol. Biol. Rep. Section Abstract Doc Link 19757155 Disease Relevance 0.67 Pain Relevance 0.59
Its action mechanisms are probably involved in the inhibition of inflammatory factor production and suppression of iNOS expression.
Negative_regulation (suppression) of Gene_expression (expression) of iNOS associated with inflammation
13) Confidence 0.48 Published 2010 Journal Mol. Biol. Rep. Section Abstract Doc Link 19757155 Disease Relevance 0.59 Pain Relevance 0.55
Anti-inflammatory activities of ent-16alphaH,17-hydroxy-kauran-19-oic acid isolated from the roots of Siegesbeckia pubescens are due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactivation.
Negative_regulation (inhibition) of Gene_expression (expression) of iNOS in RAW 264 associated with inflammation and analgesic
14) Confidence 0.48 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17207792 Disease Relevance 0.55 Pain Relevance 0.35
Naproxen treatment notably reduces PGE2 production and iNOS expression, reflecting the COX-NOS crosstalk already reported, although it causes an important increment in TNF-alpha synthesis in the epidermis of irradiated mice.
Negative_regulation (reduces) of Gene_expression (expression) of iNOS in epidermis
15) Confidence 0.48 Published 2008 Journal Cytokine Section Abstract Doc Link 18710815 Disease Relevance 0.31 Pain Relevance 0.31
A direct relationship between the UPR-inducing properties of erstressin and the ability of the compound to block iNOS expression can be inferred from several findings.
Negative_regulation (block) of Gene_expression (expression) of iNOS
16) Confidence 0.48 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.13 Pain Relevance 0.03
To identify the mechanism whereby compound 1 inhibited iNOS expression and to identify the biological pathway(s) impacted by compound 1, we then profiled global gene expression in A172 cells simultaneously treated with cytokine-stimulation media and compound.
Negative_regulation (inhibited) of Gene_expression (expression) of iNOS in A172 associated with cytokine
17) Confidence 0.48 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0 Pain Relevance 0.16
To identify small molecules that reduce the production of iNOS-derived NO, we developed a homogeneous forward chemical genetic screen in the murine macrophage cell line RAW 264.7.
Negative_regulation (reduce) of Gene_expression (production) of iNOS in macrophage
18) Confidence 0.48 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.08 Pain Relevance 0.04
First, the ability of erstressin to downregulate iNOS expression is inextricably linked to its ER stressor activity, as a subtle change in chemical structure (nostressin) abrogates the effects in both pathways.
Negative_regulation (downregulate) of Gene_expression (expression) of iNOS
19) Confidence 0.48 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.12 Pain Relevance 0.03
These data taken together led us to reinforce the hypothesis in the literature that the anti-inflammatory effect of propolis may be a due to inhibition of iNOS gene expression, through interference with NF-kappaB sites in the iNOS promoter.
Negative_regulation (inhibition) of Gene_expression (expression) of iNOS associated with inflammation
20) Confidence 0.47 Published 2006 Journal Planta Med. Section Abstract Doc Link 16902858 Disease Relevance 0.49 Pain Relevance 0.41

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