INT92858

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 1.25
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
granule cells 1
Ednra (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 6 99.68 Very High Very High Very High
Glutamate 196 99.64 Very High Very High Very High
Thermal hyperalgesia 7 99.54 Very High Very High Very High
Morphine 28 97.36 Very High Very High Very High
antinociception 4 97.36 Very High Very High Very High
Action potential 24 97.20 Very High Very High Very High
tolerance 18 94.52 High High
Potency 2 90.32 High High
agonist 4 87.60 High High
withdrawal 1 83.72 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 7 99.54 Very High Very High Very High
Blister 8 75.20 Quite High
Toxicity 8 73.80 Quite High
Nociception 1 72.24 Quite High
Increased Venous Pressure Under Development 16 71.00 Quite High
Pain 1 70.04 Quite High
Death 16 5.00 Very Low Very Low Very Low
Poisoning 8 5.00 Very Low Very Low Very Low
Shock 8 5.00 Very Low Very Low Very Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PKC beta(I), beta(II), delta, theta, epsilon, eta and xi inhibitors were inactive.
Negative_regulation (inhibitors) of eta
1) Confidence 0.57 Published 2007 Journal Pain Section Abstract Doc Link 16965856 Disease Relevance 0 Pain Relevance 1.49
The PKC beta(I), beta(II), delta, theta, epsilon, eta and xi inhibitors were inactive (up to 2500 pmol).
Negative_regulation (inhibitors) of eta
2) Confidence 0.41 Published 2007 Journal Pain Section Abstract Doc Link 16965856 Disease Relevance 0 Pain Relevance 1.56
Inhibition of endothelin ET(A) and endothelin ET(B) receptors with bosentan (1 and 10 microM) reduced basal tone.
Negative_regulation (Inhibition) of endothelin ET
3) Confidence 0.21 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11134653 Disease Relevance 0.18 Pain Relevance 0.19
Inhibition of endothelin ET(A) and endothelin ET(B) receptors with bosentan (1 and 10 microM) reduced basal tone.
Negative_regulation (Inhibition) of endothelin ET
4) Confidence 0.21 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11134653 Disease Relevance 0.18 Pain Relevance 0.18
Thermal hyperalgesia was attenuated by the inhibition of ET(A) and protein kinase C (PKC) but not that of ET(B).
Negative_regulation (inhibition) of ET associated with kinase c and thermal hyperalgesia
5) Confidence 0.16 Published 2008 Journal Neuroscience Section Abstract Doc Link 18495351 Disease Relevance 0.67 Pain Relevance 0.99
8 following ET application.
Negative_regulation (following) of ET
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.07 Pain Relevance 0.17
-cyclodextrin pre-treatment (compare panels Ai or Aii and Aiii in Fig.3) and a significant decrease in ET-induced glutamate release was observed (Fig. 3B).
Negative_regulation (decrease) of ET associated with glutamate
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0.15 Pain Relevance 0.08
These findings bring rational for explaining how TTX suppressed the stimulation of glutamate release by ET: TTX, which does not interfere with the initial depolarizing effect of ET on granule cells, prevents propagation of its consequences (i.e. the action potentials) to nerve endings.


Negative_regulation (effect) of ET in granule cells associated with action potential and glutamate
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0.16
15 mV, and the reversal potential for ET-induced current was ??
Negative_regulation (reversal) of ET
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948003 Disease Relevance 0 Pain Relevance 0

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