INT92862

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Context Info
Confidence 0.02
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pklr) carbohydrate metabolic process (Pklr) kinase activity (Pklr)
Anatomy Link Frequency
cerebral cortex 1
Pklr (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 1 98.62 Very High Very High Very High
opioid receptor 7 98.04 Very High Very High Very High
mu opioid receptor 1 93.28 High High
withdrawal 3 90.56 High High
antinociception 1 88.40 High High
narcan 1 85.20 High High
Physical dependence 2 80.72 Quite High
addiction 1 75.00 Quite High
agonist 1 54.12 Quite High
Opioid 1 53.40 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 2 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of the immunoreactivity levels of PKC-alpha, PKC-beta (I and II) and PKC-gamma isozymes in the cerebral cortex of mice infused chronically with deltorphin II showed a significant up-regulation of all these isozymes in the soluble fraction in wild-type but not in MOR-deficient mice.
Positive_regulation (up-regulation) of isozymes in cerebral cortex associated with opioid receptor and cerebral cortex
1) Confidence 0.02 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11135013 Disease Relevance 0.06 Pain Relevance 0.83

General Comments

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