INT92877

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Context Info
Confidence 0.76
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 17.10
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE5A) signal transduction (PDE5A) cellular_component (PDE5A)
Anatomy Link Frequency
endothelial cells 5
vasculature 3
pulmonary artery 2
smooth muscle 1
platelets 1
PDE5A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 39 100.00 Very High Very High Very High
adenocard 7 100.00 Very High Very High Very High
headache 46 96.76 Very High Very High Very High
nud 17 95.96 Very High Very High Very High
Angina 16 93.12 High High
Multiple sclerosis 21 88.60 High High
tolerance 24 85.36 High High
Migraine 2 85.16 High High
nMDA receptor 15 84.16 Quite High
cINOD 1 80.20 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 223 99.96 Very High Very High Very High
Pulmonary Hypertension 350 99.92 Very High Very High Very High
Pulmonary Disease 38 99.92 Very High Very High Very High
Reprotox - General 2 159 99.72 Very High Very High Very High
Airway Remodeling 1 99.60 Very High Very High Very High
Cardiovascular Disease 40 98.82 Very High Very High Very High
Schizophrenia 21 98.44 Very High Very High Very High
Diabetes Mellitus 26 96.96 Very High Very High Very High
Headache 38 96.76 Very High Very High Very High
Apoptosis 8 96.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Real time polymerase chain reaction and Western blots were used to show expression of PDE2A, PDE3B, and PDE5A in a stable cell line of human brain microvascular endothelial cells.
Gene_expression (expression) of PDE5A in endothelial cells
1) Confidence 0.76 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
Western blot detection of Phosphodiesterase-5 Protein
Gene_expression (detection) of Phosphodiesterase-5 Protein
2) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2680410 Disease Relevance 0 Pain Relevance 0
In conclusion, our results demonstrate that phosphodiesterase-5 is present in the feto-placental circulation, and that sildenafil citrate is a vasodilator in this circulation.
Gene_expression (present) of phosphodiesterase-5
3) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2680410 Disease Relevance 0.41 Pain Relevance 0
Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP), is widely expressed in the vasculature, and is best known as the target of sildenafil, a drug used to treat erectile dysfunction [67].
Gene_expression (expressed) of Phosphodiesterase 5 in vasculature associated with reprotox - general 2 and adenocard
4) Confidence 0.75 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995617 Disease Relevance 0.10 Pain Relevance 0.05
Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP), is widely expressed in the vasculature, and is best known as the target of sildenafil, a drug used to treat erectile dysfunction [67].
Gene_expression (expressed) of PDE5 in vasculature associated with reprotox - general 2 and adenocard
5) Confidence 0.75 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995617 Disease Relevance 0.10 Pain Relevance 0.05
The Princeton Consensus Recommendations were developed to provide instructions to physicians who treat men with CVD and ED and answer the most common question: is it safe to take PDE5i and engage in sexual activity?
Gene_expression (take) of PDE5i associated with reprotox - general 2 and cardiovascular disease
6) Confidence 0.67 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699643 Disease Relevance 1.01 Pain Relevance 0.12
We evaluated the presence of PDE5 mRNA and protein in human arteries.
Gene_expression (presence) of PDE5
7) Confidence 0.67 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16182282 Disease Relevance 0.31 Pain Relevance 0.26
Newer compounds have certain advantages over sildenafil, including greater selectivity for PDE-5 compared with other isoenzymes, absence of effect of food on absorption, faster onset and longer duration of action.
Gene_expression (selectivity) of PDE-5
8) Confidence 0.66 Published 2007 Journal Indian J Med Sci Section Abstract Doc Link 18174638 Disease Relevance 1.14 Pain Relevance 0.09
With the entry of three novel PDE5 inhibitors into the therapeutic armamentarium for ED, differentiating properties of the new agents may confer clinical benefits that physicians as well as patients and their partners should consider when selecting a PDE5 inhibitor.
Gene_expression (selecting) of PDE5 associated with reprotox - general 2
9) Confidence 0.65 Published 2004 Journal J Am Osteopath Assoc Section Abstract Doc Link 15083994 Disease Relevance 0.76 Pain Relevance 0.08
Hemodynamic studies have shown that therapeutic dosages of the PDE5 inhibitors produce only mild and transient changes in mean systolic and diastolic blood pressure and heart rate in healthy men as well as those with ischemic heart disease or chronic stable angina.
Gene_expression (produce) of PDE5 in heart associated with angina and coronary artery disease
10) Confidence 0.65 Published 2004 Journal J Am Osteopath Assoc Section Abstract Doc Link 15083994 Disease Relevance 0.82 Pain Relevance 0.09
The presence of PDE5 in other tissues such as vascular smooth muscle results in side effects such as headache, flushing, indigestion and nasal congestion.
Gene_expression (presence) of PDE5 in nasal associated with nud, headache and increased venous pressure under development
11) Confidence 0.65 Published 1999 Journal Expert Opin Pharmacother Section Abstract Doc Link 11249556 Disease Relevance 0.64 Pain Relevance 0.14
The promoters are responsive to cGMP or cAMP stimulation, and several studies have demonstrated regulation of PDE5 expression possibly through these promoters (Lin et al 2006).
Gene_expression (expression) of PDE5
12) Confidence 0.64 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0 Pain Relevance 0
Because PDE5 is also present in small amounts in the systemic vasculature, sildenafil can cause a synergistic and major decrease in pressure when combined with organic nitrates.
Gene_expression (present) of PDE5 in vasculature
13) Confidence 0.60 Published 2000 Journal Am. J. Med. Section Abstract Doc Link 11137498 Disease Relevance 0.68 Pain Relevance 0.07
In conclusion, PDE5 is present in human and guinea pig cerebral arteries, and is inhibited by sildenafil at micromolar levels.
Gene_expression (present) of PDE5
14) Confidence 0.60 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16182282 Disease Relevance 0.19 Pain Relevance 0.10
OBJECTIVE: To investigate nitric oxide (NO)-mediated changes in expression of cyclic nucleotide degrading phosphodiesterases 2A (PDE2A), PDE3B, and PDE5A in human endothelial cells.
Gene_expression (expression) of PDE5A in endothelial cells
15) Confidence 0.59 Published 2010 Journal Headache Section Abstract Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
RESULTS: This study shows the expression of PDE2A, PDE3B, and PDE5A mRNA and PDE3B and PDE5A protein in human cerebral endothelial cells.
Gene_expression (expression) of PDE5A in endothelial cells
16) Confidence 0.59 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
The presence of PDE3 or PDE5 in endothelial cells indicates that selective inhibitors may have functional effects in such cells.
Gene_expression (presence) of PDE5 in endothelial cells
17) Confidence 0.59 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
RESULTS: This study shows the expression of PDE2A, PDE3B, and PDE5A mRNA and PDE3B and PDE5A protein in human cerebral endothelial cells.
Gene_expression (expression) of PDE5A protein in endothelial cells
18) Confidence 0.59 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
The purposes of these studies were to determine whether the phosphodiesterase-5 enzyme was present in the feto-placental circulation, and then to characterize the effects and mechanisms of action of sildenafil citrate in this circulation.


Gene_expression (present) of phosphodiesterase-5 enzyme
19) Confidence 0.58 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2680410 Disease Relevance 0.39 Pain Relevance 0.13
The Phosphodiesterase-5 protein is present in chorionic plate arterial rings as demonstrated by Western blot.
Gene_expression (present) of Phosphodiesterase-5 protein
20) Confidence 0.58 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2680410 Disease Relevance 0 Pain Relevance 0

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