INT929

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Context Info
Confidence 0.70
First Reported 1977
Last Reported 2009
Negated 2
Speculated 8
Reported most in Abstract
Documents 64
Total Number 75
Disease Relevance 14.67
Pain Relevance 52.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 6
spinal cord 4
medulla 3
pons 3
blood 3
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 148 100.00 Very High Very High Very High
opiate 144 100.00 Very High Very High Very High
opioid receptor 125 100.00 Very High Very High Very High
narcan 92 100.00 Very High Very High Very High
Morphine 76 100.00 Very High Very High Very High
Opioid 68 100.00 Very High Very High Very High
agonist 42 100.00 Very High Very High Very High
Dynorphin 37 100.00 Very High Very High Very High
Kappa opioid receptor 18 100.00 Very High Very High Very High
withdrawal 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 58 99.96 Very High Very High Very High
Bordatella Infection 3 99.80 Very High Very High Very High
Sleep Disorders 3 99.72 Very High Very High Very High
Prostate Cancer 3 99.40 Very High Very High Very High
Pain 26 99.24 Very High Very High Very High
Nociception 8 99.24 Very High Very High Very High
Ganglion Cysts 4 98.40 Very High Very High Very High
Sprains And Strains 3 98.30 Very High Very High Very High
Frailty 2 98.28 Very High Very High Very High
Hyperalgesia 7 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in ORL1 receptors could oppose the analgesic action of morphine, contributing to tolerance.
Positive_regulation (increase) of ORL1
1) Confidence 0.70 Published 2005 Journal Indian J. Med. Res. Section Body Doc Link 15802762 Disease Relevance 0 Pain Relevance 0
The data are discussed in connection with the hypothesis that morphine acts directly on reinforcement mechanisms by activating the opiate receptor.
Positive_regulation (activating) of opiate receptor associated with opiate and morphine
2) Confidence 0.70 Published 1979 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 113818 Disease Relevance 0 Pain Relevance 0.48
Marked region-specific up-regulation of the micro, delta, and kappa opioid receptors but not ORL1 receptors was observed in proenkephalin and prodynorphin knockouts.
Positive_regulation (up-regulation) of ORL1 associated with kappa opioid receptor
3) Confidence 0.69 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614912 Disease Relevance 0.23 Pain Relevance 0.60
Region selective up-regulation of micro-, delta- and kappa-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice.
Positive_regulation (up-regulation) of opioid receptor-like 1 in brains associated with targeted disruption, dynorphin, kappa opioid receptor, enkephalin and opioid receptor
4) Confidence 0.69 Published 2003 Journal Neuroscience Section Title Doc Link 14614912 Disease Relevance 0.26 Pain Relevance 0.91
Cerebroside sulfate (CS) appears to fulfill most of the structural requirements of a hypothetical opiate receptor.
Positive_regulation (requirements) of opiate receptor associated with opiate
5) Confidence 0.69 Published 1978 Journal Fed. Proc. Section Abstract Doc Link 203492 Disease Relevance 0 Pain Relevance 0.36
Nociceptin/orphanin FQ knockout mice display up-regulation of the opioid receptor-like 1 receptor and alterations in opioid receptor expression in the brain.
Positive_regulation (up-regulation) of opioid receptor-like 1 receptor in brain associated with targeted disruption, orphanin and opioid receptor
6) Confidence 0.69 Published 2003 Journal Neuroscience Section Title Doc Link 12605902 Disease Relevance 0.64 Pain Relevance 1.53
In conclusion the region-specific up-regulation of the opioid receptor-like 1 receptor indicates a tonic role for nociceptin/orphanin FQ in some brain structures and may suggest the peptide regulates the receptor expression in these regions.
Positive_regulation (up-regulation) of opioid receptor-like 1 receptor in brain structures associated with orphanin and opioid receptor
7) Confidence 0.69 Published 2003 Journal Neuroscience Section Abstract Doc Link 12605902 Disease Relevance 0.36 Pain Relevance 1.16
A region-specific up-regulation of the opioid receptor-like 1 receptor (up to 135%) was seen in brains from homozygous mice.
Positive_regulation (up-regulation) of opioid receptor-like 1 receptor in brains associated with opioid receptor
8) Confidence 0.69 Published 2003 Journal Neuroscience Section Abstract Doc Link 12605902 Disease Relevance 0.52 Pain Relevance 1.52
Our results indicate that the antinociceptive effect of buprenorphine in mice is micro-opioid receptor-mediated yet severely compromised by concomitant activation of ORL-1 receptors.
Positive_regulation (activation) of ORL-1 associated with opioid receptor, antinociceptive and buprenorphine
9) Confidence 0.66 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614092 Disease Relevance 0 Pain Relevance 1.86
In addition to activation of the opiate receptor through the endogenous release of opioids, pharmacotherapy with opiate receptor agonists is frequently used for sedation and analgesia of injured, septic and critically ill patients.
Positive_regulation (activation) of opiate receptor associated with critical illness, agonist, opiate, sleep disorders, opioid and analgesia
10) Confidence 0.66 Published 2006 Journal J. Intern. Med. Section Abstract Doc Link 16420543 Disease Relevance 0.73 Pain Relevance 1.18
In Experiment 3, an increase in opiate receptor sensitivity produced by chronic naltrexone treatment did not affect the strength of the taste aversion, but resulted in an increase in the magnitude of the conditioned analgesic response.
Positive_regulation (increase) of opiate receptor associated with appetite loss, analgesic and opiate
11) Confidence 0.66 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2167492 Disease Relevance 0.42 Pain Relevance 1.09
Influence of a deletion of protein kinase C gamma isoform in the G-protein activation mediated through opioid receptor-like-1 and mu-opioid receptors in the mouse pons/medulla.
Positive_regulation (activation) of opioid receptor-like-1 in pons associated with medulla, kinase c, mu opioid receptor and opioid receptor
12) Confidence 0.66 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12359310 Disease Relevance 0.13 Pain Relevance 0.77
Brain stimulation in the opiate receptor system may be effective through activation of this system.
Positive_regulation (stimulation) of opiate receptor in Brain associated with opiate
13) Confidence 0.65 Published 1978 Journal Electroencephalogr Clin Neurophysiol Suppl Section Abstract Doc Link 312190 Disease Relevance 0.45 Pain Relevance 0.75
This finding suggests that antagonist-induced opiate receptor upregulation does not require the synthesis of new receptor molecules.
Positive_regulation (upregulation) of opiate receptor associated with antagonist and opiate
14) Confidence 0.64 Published 1986 Journal Brain Res. Section Abstract Doc Link 3006869 Disease Relevance 0.15 Pain Relevance 0.73
These findings demonstrate that thyroxine increases opiate receptor number and native pain sensitivity but decreases the duration of analgesia from morphine.
Positive_regulation (increases) of opiate receptor associated with pain, opiate, morphine and analgesia
15) Confidence 0.59 Published 1990 Journal Life Sci. Section Abstract Doc Link 2176266 Disease Relevance 0.41 Pain Relevance 1.15
Significant increases in nociceptin receptor binding were also observed in homozygous mice in brain areas involved in motor behavior.
Positive_regulation (increases) of nociceptin receptor in brain associated with orphanin
16) Confidence 0.57 Published 2008 Journal Neuroscience Section Abstract Doc Link 18424009 Disease Relevance 0.08 Pain Relevance 0.53
BACKGROUND: Agonists at the opioid receptor-like receptor 1 (ORL1) induce motor impairment, sedation, and loss of righting reflex (LRR) in rodents.
Positive_regulation (induce) of ORL1 associated with agonist, opioid receptor and sleep disorders
17) Confidence 0.50 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179266 Disease Relevance 0.10 Pain Relevance 0.26
As a number of studies have proposed a close association between the classical opioid receptors and the ORL1 system we also hypothesized that loss of all of the classical opioid receptors might lead to compensatory changes in ORL1 receptors.
Positive_regulation (changes) of ORL1 associated with opioid receptor
18) Confidence 0.50 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12431223 Disease Relevance 0.45 Pain Relevance 0.70
While naloxone benzoylhydrazone (1 mg/kg), a putative antagonist for nociceptin receptor/naloxone benzoylhydrazone-sensitive sites, also induced the morphine withdrawal signs in both wild-type and the nociceptin receptor knockout mice, the jumping signs in the nociceptin receptor knockout mice were less severe than those in wild-type mice.
Positive_regulation (induced) of nociceptin receptor associated with targeted disruption, orphanin, antagonist, narcan, withdrawal and morphine
19) Confidence 0.50 Published 2001 Journal J Neural Transm Section Abstract Doc Link 11810400 Disease Relevance 0.94 Pain Relevance 2.17
Activation of the opioid receptor-like 1 receptor by nociceptin/orphanin FQ in vivo produces hyperalgesia when this peptide is given supraspinally but analgesia at the spinal level.
Positive_regulation (Activation) of opioid receptor-like 1 receptor in spinal associated with hyperalgesia, orphanin, opioid receptor and analgesia
20) Confidence 0.50 Published 2003 Journal Neuroscience Section Abstract Doc Link 12605902 Disease Relevance 0.61 Pain Relevance 1.38

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