INT9290

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Context Info
Confidence 0.09
First Reported 1984
Last Reported 1992
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.69
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pomc, Prl) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc)
extracellular space (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
third ventricle 1
Pomc (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 6 100.00 Very High Very High Very High
Opioid 2 99.98 Very High Very High Very High
Glutamate 1 97.52 Very High Very High Very High
Central nervous system 1 72.64 Quite High
Intracerebroventricular 1 60.28 Quite High
amygdala 1 41.44 Quite Low
midbrain 1 40.64 Quite Low
Disease Link Frequency Relevance Heat
Stress 4 100.00 Very High Very High Very High
Galactorrhea 2 89.20 High High
Hemorrhage 4 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to determine the site(s) at which the opioid peptide beta-endorphin (beta-END) acts to influence plasma LH and PRL levels in the ovariectomized (OVX) rat. beta-END, administered into the third ventricle of conscious OVX rats fitted with jugular catheters, significantly decreased plasma LH in doses greater than or equal to 50 ng and increased PRL levels at all doses administered (10, 50, 100 and 250 ng) in a dose dependent fashion.
peptide beta-endorphin Regulation (influence) of PRL in third ventricle associated with opioid
1) Confidence 0.09 Published 1984 Journal Life Sci. Section Abstract Doc Link 6323905 Disease Relevance 0 Pain Relevance 0.23
Prolactin response to anesthetic stress and beta-endorphin is altered in female rats treated neonatally with monosodium glutamate.
beta-endorphin Regulation (response) of Prolactin associated with stress, anesthesia and glutamate
2) Confidence 0.05 Published 1992 Journal Neuropeptides Section Title Doc Link 1407411 Disease Relevance 0.69 Pain Relevance 0.48

General Comments

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