INT92902

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.06
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
striatum 2
hippocampus 2
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 295 100.00 Very High Very High Very High
Glutamate receptor 9 100.00 Very High Very High Very High
agonist 3 100.00 Very High Very High Very High
cocaine 7 99.98 Very High Very High Very High
tetrodotoxin 2 99.98 Very High Very High Very High
Inflammation 7 99.76 Very High Very High Very High
Nucleus accumbens 2 99.08 Very High Very High Very High
lidocaine 1 98.60 Very High Very High Very High
Hippocampus 32 98.24 Very High Very High Very High
local anesthetic 1 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.76 Very High Very High Very High
Anaerobic Bacterial Infections 1 98.56 Very High Very High Very High
Anxiety Disorder 154 85.76 High High
Injury 1 81.44 Quite High
Pain 3 80.08 Quite High
Shock 44 79.92 Quite High
Hyperalgesia 1 75.00 Quite High
Overdose 4 5.00 Very Low Very Low Very Low
Amnesia 3 5.00 Very Low Very Low Very Low
Aids-related Complex 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
45 h after IA training, prevent the rapid increase in GluR1 protein induced by IA training necessary for memory consolidation.
Negative_regulation (prevent) of Positive_regulation (increase) of GluR1 protein
1) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.08 Pain Relevance 0.19
Moreover, we observed that rats sensitized to cocaine presented a significant increase in the levels of GLUR1, NR1 and NR2B, in the nucleus accumbens, and of NR2B in the hippocampus compared to control animals.
Negative_regulation (presented) of Positive_regulation (increase) of GLUR1 in hippocampus associated with nucleus accumbens, hippocampus and cocaine
2) Confidence 0.35 Published 2002 Journal Neuroscience Section Abstract Doc Link 11801363 Disease Relevance 0 Pain Relevance 1.34
The upregulation of phosphoserine 831 GluR1 was attenuated by pretreatment with chelerythrine, a selective PKC inhibitor, KN-93, a selective CaMKII inhibitor, and two NMDA receptor antagonists, MK-801 and APV.
Negative_regulation (attenuated) of Positive_regulation (upregulation) of GluR1 associated with nmda receptor antagonist
3) Confidence 0.34 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15276247 Disease Relevance 0.59 Pain Relevance 0.98
Relative to vehicle controls, naive rats given intra-LA infusion of Ifenprodil prior to sacrifice at the same time as the trained animals described above exhibited no significant differences in levels of GluR1, synapsin, or synaptophysin in the LA [GluR1: t(7)?
Neg (no) Negative_regulation (exhibited) of Positive_regulation (levels) of GluR1 associated with amygdala
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.14 Pain Relevance 0.41
Relative to vehicle controls, naive rats given intra-LA infusion of Ifenprodil prior to sacrifice at the same time as the trained animals described above exhibited no significant differences in levels of GluR1, synapsin, or synaptophysin in the LA [GluR1: t(7)?
Neg (no) Negative_regulation (exhibited) of Positive_regulation (levels) of GluR1 associated with amygdala
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.15 Pain Relevance 0.41
Preincubation with the Na(+) channel blocker tetrodotoxin abolished the glutamate receptor agonist-induced increases except in the striatum following kainic acid infusion.
Negative_regulation (abolished) of Neg (except) Positive_regulation (increases) of glutamate receptor in striatum associated with tetrodotoxin, glutamate receptor and agonist
6) Confidence 0.25 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11137867 Disease Relevance 0 Pain Relevance 0.46
Each stimulation protocol resulted in a significant increase in BDNF release that was tetrodotoxin sensitive and occurred in the absence of glutamate receptor activation.
Negative_regulation (absence) of Positive_regulation (activation) of glutamate receptor associated with tetrodotoxin and glutamate receptor
7) Confidence 0.13 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451139 Disease Relevance 0.10 Pain Relevance 0.30

General Comments

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