INT92916

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Context Info
Confidence 0.74
First Reported 2001
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 50
Total Number 52
Disease Relevance 17.52
Pain Relevance 6.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Acta2) cytoplasm (Acta2)
Anatomy Link Frequency
PSCs 17
smooth muscle 14
hepatocytes 2
myometrium 1
muscle 1
Acta2 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 67 100.00 Very High Very High Very High
COX-2 inhibitor 5 96.96 Very High Very High Very High
Chronic pancreatitis 67 96.92 Very High Very High Very High
Dismenorea 13 95.76 Very High Very High Very High
cytokine 34 95.16 Very High Very High Very High
Inflammation 12 94.52 High High
alcohol 4 90.20 High High
Inflammatory response 5 82.08 Quite High
Pain 8 79.60 Quite High
addiction 3 74.16 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 77 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 38 100.00 Very High Very High Very High
Cutaneous Melanoma 1 99.64 Very High Very High Very High
Stress 32 99.36 Very High Very High Very High
Aggression 15 98.72 Very High Very High Very High
Primitive Neuroectodermal Tumors 27 98.64 Very High Very High Very High
Injury 37 97.92 Very High Very High Very High
Cancer 371 97.24 Very High Very High Very High
Shock 151 96.92 Very High Very High Very High
Pancreatitis 73 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although tamoxifen induces inner myometrial changes including that of ACTA2, desmin, ESR1 and laminin expression in C57/BL6J neonatal mice similar to those induced in CD-1 mice, C57/BL6J mice did not develop premature adenomyosis.
Gene_expression (expression) of ACTA2 associated with dismenorea
1) Confidence 0.74 Published 2010 Journal Reproduction Section Abstract Doc Link 20368191 Disease Relevance 0.29 Pain Relevance 0.37
The inner myometrium showed thinning, lack of continuity, disorganization, and bundling. alpha-SMA expression was normal.
Gene_expression (expression) of alpha-SMA in myometrium
2) Confidence 0.50 Published 2009 Journal Reproduction Section Abstract Doc Link 19451194 Disease Relevance 0.32 Pain Relevance 0.32
-gal-positive cells expressed Acta2, whereas not all of the Acta2-expressing cells were ?
Gene_expression (expressed) of Acta2
3) Confidence 0.47 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570687 Disease Relevance 0.15 Pain Relevance 0
Expression of mRNA for collagen alpha1(I), alpha-smooth muscle actin or CTGF were all increased and co-localized exclusively to activated PSC in ACP.
Gene_expression (Expression) of alpha-smooth muscle actin in PSC associated with primary sclerosing cholangitis and chronic pancreatitis
4) Confidence 0.29 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.31 Pain Relevance 0.71
In mice receiving ethanol plus cerulein, there was increased collagen deposition as compared with other treatment groups as well as increased frequency of alpha-smooth muscle actin and desmin-positive PSC, which also showed significantly enhanced CTGF protein production.
Gene_expression (production) of alpha-smooth muscle actin in PSC associated with primary sclerosing cholangitis
5) Confidence 0.25 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.31 Pain Relevance 0.71
SRF plays a prominent role in regulating the expression of heart muscle genes [33] and may explain increases in muscle contraction genes (ACTA1, ACTA2, DES, MYL1, MYL2, MYL3, MYL9, MYOM1, TNNC2, TNNT1, TNNT3, TPM2, TPM4) after HS.
Gene_expression (expression) of ACTA2 in muscle associated with shock
6) Confidence 0.19 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.75 Pain Relevance 0
DA-9601 decreased the expressions of alpha-SMA and type I collagen in cultured pancreatic stellate cells.
Gene_expression (expressions) of alpha-SMA in stellate cells
7) Confidence 0.15 Published 2005 Journal Pancreatology Section Body Doc Link 15849487 Disease Relevance 0.16 Pain Relevance 0
Furthermore, using alpha-smooth muscle actin (?
Gene_expression (using) of alpha-smooth muscle actin in smooth muscle
8) Confidence 0.08 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.30 Pain Relevance 0
We define the MSC derived TAF in a xenograft ovarian carcinoma model by the immunohistochemical presence of 1) fibroblast specific protein and fibroblast activated protein; 2) markers phenotypically associated with aggressiveness, including tenascin-c, thrombospondin-1, and stromelysin-1; 3) production of pro-tumorigenic growth factors including hepatocyte growth factor, epidermal growth factor, and interleukin-6; and 4) factors indicative of vascularization, including alpha-smooth muscle actin, desmin, and vascular endothelial growth factor.
Gene_expression (production) of alpha-smooth muscle actin in hepatocyte associated with aggression and ovarian cancer
9) Confidence 0.07 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2661372 Disease Relevance 0.98 Pain Relevance 0.10
Independently of age, MSC transplanted into liver did not differentiate into hepatocytes but remained mesenchymal and expressed collagen and alpha smooth muscle actin (?
Gene_expression (expressed) of alpha smooth muscle actin in hepatocytes
10) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.64 Pain Relevance 0.12
Engrafted MSC in liver express alpha smooth muscle actin and their localization merges with collagen deposition
Gene_expression (express) of alpha smooth muscle actin in smooth muscle
11) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.09 Pain Relevance 0.05
Whether the increased expression of alpha smooth muscle actin is related to the tumorgenic nature of Huh-7 cells has to be determined.
Gene_expression (expression) of alpha smooth muscle actin in smooth muscle
12) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0 Pain Relevance 0
After intrahepatic injection, MSC permanently remained in liver tissue, kept a mesenchymal morphology and expressed vimentin and alpha smooth muscle actin, but no hepatic markers.
Neg (no) Gene_expression (expressed) of alpha smooth muscle actin in smooth muscle
13) Confidence 0.04 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2722022 Disease Relevance 0.12 Pain Relevance 0
Immunohistochemically, the spindled cells were diffusely positive for smooth muscle actin (SMA) and weakly expressed vimentin and inhibin.
Gene_expression (expressed) of smooth muscle actin in smooth muscle
14) Confidence 0.03 Published 2008 Journal Cases J Section Body Doc Link PMC2579288 Disease Relevance 0.77 Pain Relevance 0.03
Epithelial membrane antigen (EMA) and smooth muscle actin (SMA) may occasionally be expressed.
Gene_expression (expressed) of smooth muscle actin in smooth muscle
15) Confidence 0.03 Published 2007 Journal Diagn Pathol Section Abstract Doc Link PMC1913496 Disease Relevance 0.40 Pain Relevance 0
Immunohistochemically SFT commonly expresses CD34, CD99 and bcl-2, epithelial membrane antigen (EMA), and smooth muscle actin (SMA) may occasionally be expressed.
Gene_expression (expressed) of smooth muscle actin in smooth muscle
16) Confidence 0.03 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1913496 Disease Relevance 0.57 Pain Relevance 0
Immunohistochemically, the spindled cells were diffusely positive for smooth muscle actin (SMA) and weakly expressed vimentin.
Gene_expression (expressed) of smooth muscle actin in smooth muscle
17) Confidence 0.02 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2217290 Disease Relevance 0.70 Pain Relevance 0.13
Pancreatic blood flow was detected by intravital microscope; malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were measured in pancreatic tissues for assessment of oxidative stress and alpha-smooth muscle actin (alpha-SMA) expression was determined by immunohistochemical staining and RT-PCR.
Gene_expression (expression) of alpha-SMA in blood associated with stress
18) Confidence 0.02 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16814251 Disease Relevance 0.80 Pain Relevance 0.07
In addition, alpha-SMA expression was up-regulated significantly (p < 0.05).
Gene_expression (expression) of alpha-SMA
19) Confidence 0.02 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16814251 Disease Relevance 0.69 Pain Relevance 0.05
In vitro, IS-741 has no direct effect on the proliferation, alpha-SMA expression, and collagen synthesis of PSCs.
Gene_expression (expression) of alpha-SMA in PSCs
20) Confidence 0.02 Published 2007 Journal Pancreas Section Body Doc Link 17414052 Disease Relevance 0.06 Pain Relevance 0

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