INT9292

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Context Info
Confidence 0.67
First Reported 1982
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 93
Total Number 94
Disease Relevance 35.13
Pain Relevance 23.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
tibia 2
stage 3 2
epithelial cells 2
dorsal root ganglia 2
plasma 1
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 17 100.00 Very High Very High Very High
spinal-cord stimulation 5 100.00 Very High Very High Very High
Botox 3 100.00 Very High Very High Very High
Dopamine 27 99.98 Very High Very High Very High
Dynorphin 11 99.98 Very High Very High Very High
isoflurane 10 99.98 Very High Very High Very High
cINOD 9 99.98 Very High Very High Very High
opioid receptor 31 99.96 Very High Very High Very High
mu opioid receptor 17 99.96 Very High Very High Very High
Enkephalin 6 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 136 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 14 100.00 Very High Very High Very High
Familial Amyloidotic Polyneuropathy 6 100.00 Very High Very High Very High
Stress 5 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia 1 100.00 Very High Very High Very High
Herpes Simplex Virus 1 100.00 Very High Very High Very High
Primary Hyperoxaluria 1 100.00 Very High Very High Very High
Tyrosinemia 11 99.98 Very High Very High Very High
Myocardial Infarction 2 99.98 Very High Very High Very High
Cystic Fibrosis 5 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mineral density and histomorphometric assessment of bone changes in the proximal tibia early after induction of type II collagen-induced arthritis in growing and mature rats.
Positive_regulation (induction) of type in tibia associated with arthritis
1) Confidence 0.67 Published 2001 Journal J. Bone Miner. Metab. Section Title Doc Link 11281163 Disease Relevance 1.41 Pain Relevance 0.49
Pulsatile activation of type D2 dopamine receptors is reported to be the principal factor in the triggering of dyskinesias and may well be involved in the priming phenomenon.
Positive_regulation (activation) of type associated with dopamine receptor and dyskinesias
2) Confidence 0.67 Published 2000 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 10740093 Disease Relevance 1.12 Pain Relevance 0.23
Children aged 1-12 y with a history of bloody mucoid diarrhoea of less than 5 d duration were enrolled after their stool specimen was found to be positive for Shigella dysenteriae type I antigen by a rapid diagnostic fluorescent antibody staining test.
Positive_regulation (positive) of type associated with diarrhoea
3) Confidence 0.67 Published 2001 Journal Acta Paediatr. Section Abstract Doc Link 11853331 Disease Relevance 0.50 Pain Relevance 0
Dopamine added to cells expressing D1A receptors and type V adenylyl cyclase significantly stimulated type V enzyme activity.
Positive_regulation (stimulated) of type associated with dopamine
4) Confidence 0.67 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700117 Disease Relevance 0.06 Pain Relevance 0.74
Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction.
Positive_regulation (increased) of type in ureter associated with cox1
5) Confidence 0.67 Published 2006 Journal Kidney Int. Section Title Doc Link 16820795 Disease Relevance 0.17 Pain Relevance 0.28
This quantitative study demonstrated a specific and strong overexpression of osteocalcin mRNA in HO-isolated cells associated with a significant upregulation of type 1 collagen and osteonectin mRNA while histological analysis showed only small cellular variations.
Positive_regulation (upregulation) of type associated with heterotopic ossification
6) Confidence 0.67 Published 2004 Journal Exp. Mol. Pathol. Section Abstract Doc Link 14738867 Disease Relevance 0.88 Pain Relevance 0.08
Most general anaesthetic agents produce anaesthesia by increasing the activity of inhibitory gamma-aminobutyric acid type A receptors.
Positive_regulation (increasing) of type
7) Confidence 0.67 Published 2006 Journal Best Pract Res Clin Anaesthesiol Section Abstract Doc Link 16634415 Disease Relevance 0 Pain Relevance 0.24
The ensuing research established that the neuropharmacological properties of capsaicin are due to its activation of the transient receptor potential ion channel of the vanilloid type 1 (TRPV1).
Positive_regulation (activation) of type associated with qutenza
8) Confidence 0.67 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464036 Disease Relevance 0.46 Pain Relevance 0.69
Dopamine was more efficacious in stimulating type VII adenylyl cyclase activity in cells concomitantly transfected with the beta gamma subunit cDNAs than in cells not transfected with these G protein subunits.
Positive_regulation (stimulating) of type associated with dopamine
9) Confidence 0.67 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700117 Disease Relevance 0.08 Pain Relevance 0.85
The depression was blocked by the opioid receptor antagonists naloxone and norbinaltorphimine, suggesting that the effect was mediated by dynorphin activation of kappa 1 type opioid receptors.
Positive_regulation (activation) of type associated with dynorphin, depression, antagonist, narcan and opioid receptor
10) Confidence 0.67 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7911518 Disease Relevance 0.10 Pain Relevance 0.67
The opioid-induced stimulation of type II adenylyl cyclase was mediated via pertussis toxin-sensitive Gi proteins, because it was abolished completely by the toxin.
Positive_regulation (stimulation) of type associated with bordatella infection and opioid
11) Confidence 0.67 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595566 Disease Relevance 0.24 Pain Relevance 0.63
Hence, they represented network, GABA-mediated potentials mainly reflecting the activation of type A receptors following GABA release from interneurons.
Positive_regulation (activation) of type in interneurons associated with gaba
12) Confidence 0.67 Published 2001 Journal Neuroscience Section Abstract Doc Link 11530219 Disease Relevance 0 Pain Relevance 0.65
Previous studies have described the efficacy of injections of botulinum toxin type-A (BTX-A) to the long flexors of the toes, but this is often unsatisfactory as high dosages (up to 175 units) have been required, and patients often report significant residual toe clawing.
Positive_regulation (injections) of type
13) Confidence 0.49 Published 2006 Journal Parkinsonism Relat. Disord. Section Abstract Doc Link 16198612 Disease Relevance 0.54 Pain Relevance 0.14
Serum bone-type alkaline phosphatase was increased at the fourth week in groups H and M and decreased at the 48th week in group H.
Positive_regulation (increased) of type
14) Confidence 0.49 Published 1999 Journal Osteoporos Int Section Abstract Doc Link 10550446 Disease Relevance 0.28 Pain Relevance 0.09
[A case of multiple endocrine neoplasia type 2A (MEN2A) with a mutation in the RET gene].
Positive_regulation (multiple) of type associated with multiple endocrine neoplasia type 2a and multiple endocrine neoplasia
15) Confidence 0.49 Published 1999 Journal Hinyokika Kiyo Section Title Doc Link 10442282 Disease Relevance 0.78 Pain Relevance 0.14
It can be concluded that wild-type p53 and/or up-regulation of c-myc is associated with indomethacin-mediated differential apoptosis in gastric epithelial cells.
Positive_regulation (up-regulation) of type in epithelial cells associated with apoptosis
16) Confidence 0.49 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.79 Pain Relevance 0
GABA(A) (gamma-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are targeted by many clinically important drugs.
Positive_regulation (mediate) of type in brain associated with gaba
17) Confidence 0.49 Published 2005 Journal Nat. Rev. Neurosci. Section Abstract Doc Link 15959466 Disease Relevance 0.08 Pain Relevance 0.27
Mineral density and histomorphometric assessment of bone changes in the proximal tibia early after induction of type II collagen-induced arthritis in growing and mature rats.
Positive_regulation (induction) of type in tibia associated with arthritis
18) Confidence 0.49 Published 2001 Journal J. Bone Miner. Metab. Section Title Doc Link 11281163 Disease Relevance 1.41 Pain Relevance 0.49
The following biomarkers were measured by enzyme-linked immunosorbent assay: the proteoglycan aggrecan 846 epitope, a marker of cartilage turnover; C-propeptide of type II collagen (CPII), a biosynthesis marker; and the Col2-3/4(long mono) (C2C) and Col2-3/4(short) (C1-2C) neoepitopes, reflecting collagen cleavage of type II collagen and type I/type II collagen, respectively.
Positive_regulation (reflecting) of type in cleavage
19) Confidence 0.49 Published 2005 Journal Arthritis Rheum. Section Body Doc Link 15751093 Disease Relevance 0 Pain Relevance 0
This novel derivative of botulinum neurotoxin type A demonstrates prolonged analgesic activity in vivo.
Positive_regulation (derivative) of type associated with analgesic
20) Confidence 0.49 Published 2004 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15500391 Disease Relevance 0.64 Pain Relevance 0.58

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