INT92934

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 5.13
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (GRPR) plasma membrane (GRPR) signal transducer activity (GRPR)
Anatomy Link Frequency
neurons 3
GRPR (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 9 99.54 Very High Very High Very High
Pain 15 98.44 Very High Very High Very High
pruritus 42 96.44 Very High Very High Very High
Inflammation 4 95.92 Very High Very High Very High
Chronic pancreatitis 4 94.76 High High
Central nervous system 12 83.28 Quite High
antagonist 7 71.92 Quite High
cytokine 6 70.96 Quite High
agonist 4 70.32 Quite High
c fibre 3 66.56 Quite High
Disease Link Frequency Relevance Heat
Pruritus 138 99.16 Very High Very High Very High
Pain 18 98.44 Very High Very High Very High
Pancreatic Cancer 4 97.28 Very High Very High Very High
Skin Diseases 3 96.48 Very High Very High Very High
INFLAMMATION 6 95.92 Very High Very High Very High
Pancreatitis 5 94.76 High High
Skin Allergy 9 87.56 High High
Lichen 3 86.00 High High
Amyloidosis 3 85.44 High High
Eczema 9 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such a selective expression of bombesin receptor subtypes in pancreatic tissues may not only be of pathophysiological significance but may represent the basis for potential diagnostic and therapeutic clinical applications of bombesin analogs, including GRP receptor scintigraphy to differentiate chronic pancreatitis from ductal pancreatic carcinoma.
Gene_expression (expression) of bombesin receptor associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.67 Published 2000 Journal Lab. Invest. Section Abstract Doc Link 11140694 Disease Relevance 0.80 Pain Relevance 0.39
These neurons did respond to histamine and capsaicin (these cells had also expressed GRP, the ligand for GRPR) as well as to histamine, providing evidence that these cells play an important role in pruritus.
Gene_expression (expressed) of GRPR in neurons associated with qutenza and pruritus
2) Confidence 0.46 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950052 Disease Relevance 1.44 Pain Relevance 0.34
New evidence for a specific pathway for itch was generated by the findings of neurons expressing a gastrin-releasing peptide receptor (GRPR) gene that transmit only itch and not pain [11].
Gene_expression (expressing) of gastrin-releasing peptide receptor in neurons associated with pain and pruritus
3) Confidence 0.46 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950052 Disease Relevance 1.45 Pain Relevance 0.42
New evidence for a specific pathway for itch was generated by the findings of neurons expressing a gastrin-releasing peptide receptor (GRPR) gene that transmit only itch and not pain [11].
Gene_expression (expressing) of GRPR in neurons associated with pain and pruritus
4) Confidence 0.46 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950052 Disease Relevance 1.45 Pain Relevance 0.42

General Comments

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