INT92935

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Context Info
Confidence 0.32
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.99
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (GRPR) plasma membrane (GRPR) signal transducer activity (GRPR)
Anatomy Link Frequency
neurons 1
GRPR (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 100.00 Very High Very High Very High
qutenza 3 99.16 Very High Very High Very High
agonist 2 97.84 Very High Very High Very High
antagonist 3 97.32 Very High Very High Very High
pruritus 14 96.44 Very High Very High Very High
cytokine 2 70.96 Quite High
Central nervous system 4 64.16 Quite High
Pain 5 56.64 Quite High
Inflammation 2 48.72 Quite Low
Opioid 3 29.84 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 5 100.00 Very High Very High Very High
Pancreatic Cancer 4 100.00 Very High Very High Very High
Pruritus 46 96.44 Very High Very High Very High
Lichen 1 86.00 High High
Amyloidosis 1 85.44 High High
Disease 2 85.20 High High
Cancer 1 80.48 Quite High
Skin Allergy 3 72.84 Quite High
Eczema 3 66.56 Quite High
Pain 6 56.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of bombesin receptor subtypes has been evaluated in specimens of human pancreatic tissues with chronic pancreatitis (n = 23) and ductal pancreatic carcinoma (n = 29) with in vitro receptor autoradiography on tissue sections incubated with 125I-[Tyr4]-bombesin or the universal ligand 125I-[D-Tyr6, beta-Ala11, Phe13, Nle14]-bombesin(6-14) as radioligands and displaced by subtype-selective bombesin receptor agonists and antagonists.
bombesin receptor Binding (radioligands) of associated with antagonist, pancreatic cancer, agonist and chronic pancreatitis
1) Confidence 0.32 Published 2000 Journal Lab. Invest. Section Abstract Doc Link 11140694 Disease Relevance 0.61 Pain Relevance 0.28
These neurons did respond to histamine and capsaicin (these cells had also expressed GRP, the ligand for GRPR) as well as to histamine, providing evidence that these cells play an important role in pruritus.
GRPR Binding (ligand) of in neurons associated with qutenza and pruritus
2) Confidence 0.29 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950052 Disease Relevance 1.38 Pain Relevance 0.34

General Comments

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