INT9295

Context Info Confidence 0.56 First Reported 1980 Last Reported 2009 Negated 2 Speculated 2 Reported most in Body Documents 12 Total Number 14 Disease Relevance 3.32 Pain Relevance 3.60

mitochondrion (MAOB) small molecule metabolic process (MAOB) oxidoreductase activity (MAOB)

Anatomy Link Frequency brain 6 plasma 1 medial 1 cerebral cortex 1 neuron 1 MAOB (Homo sapiens)

Pain Link Frequency Relevance Heat monoamine 24 100.00 cerebral cortex 17 100.00 Dismenorea 5 100.00 Enkephalin 1 100.00 Serotonin 12 99.92 Cholecystokinin 1 99.48 addiction 2 98.54 drug abuse 4 98.26 alcohol 2 97.60 Neurotransmitter 3 95.32

Disease Link Frequency Relevance Heat Reprotox - General 1 5 100.00 Convulsion 48 99.74 Death 8 99.36 Epilepsy 45 99.18 Drug Dependence 4 98.26 Manic Depressive Disorder 4 95.84 Disease 44 95.28 Handedness 6 95.12 Anxiety Disorder 31 92.72 Autism 41 92.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Similarly, no changes in the activities of choline acetyltransferase, tyrosine hydroxylase or MAO-B were observed in brains of alcoholics as compared to the control population.

Neg (no) Regulation (changes) of MAO-B in brains

1) Confidence 0.56 Published 1985 Journal Alcohol Section Abstract Doc Link 2862881 Disease Relevance 0.27 Pain Relevance 0.38

The MAOA and MAOB genes are located on the X chromosome (Xp11) [63] and code for enzymes that catalyze the deamination of biogenic amines including the neurotransmitters norephinephrine, dopamine and serotonin.

Regulation (located) of MAOB associated with dopamine, neurotransmitter and serotonin

2) Confidence 0.44 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.47 Pain Relevance 0.56

Older monoamine oxidase inhibitors nonselectively inhibited both types A and B, whereas newer selective drugs specifically target MAO type B.

Regulation (target) of MAO type B associated with monoamine

3) Confidence 0.25 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2695242 Disease Relevance 0.40 Pain Relevance 0.35

Effect of plasma from premenstrual syndrome and control patients on human platelet and rat brain synaptosome monoamine oxidase B activity.

Regulation (Effect) of monoamine oxidase B in plasma associated with dismenorea and monoamine

4) Confidence 0.19 Published 1992 Journal Neuropsychobiology Section Title Doc Link 1407477 Disease Relevance 0.37 Pain Relevance 0.53

The post-ischemic effects on cerebral cortex and basal ganglia monoamine levels and monoamine oxidase (MAO A and B) and catechol-O-methyl transferase (COMT) activities were evaluated in Mongolian gerbils (Meriones unguiculatus) subjected to bilateral common carotid arteries of occlusion for 15 min and reflow for 7 days.

Regulation (effects) of monoamine oxidase in basal ganglia associated with cerebral cortex and monoamine

5) Confidence 0.11 Published 1980 Journal Acta Neuropathol. Section Abstract Doc Link 7435143 Disease Relevance 0.21 Pain Relevance 0.53

All participants were screened to exclude substance abuse or dependence within the preceding 6 months, and any independent condition that might affect brain function.

Spec (might) Regulation (affect) of brain in brain associated with addiction and drug abuse

6) Confidence 0.05 Published 2008 Journal Brain Section Body Doc Link PMC2525446 Disease Relevance 1.11 Pain Relevance 0.22

The post-ischemic effects on cerebral cortex and basal ganglia monoamine levels and monoamine oxidase (MAO A and B) and catechol-O-methyl transferase (COMT) activities were evaluated in Mongolian gerbils (Meriones unguiculatus) subjected to bilateral common carotid arteries of occlusion for 15 min and reflow for 7 days.

Regulation (effects) of monoamine oxidase in cerebral cortex associated with cerebral cortex and monoamine

7) Confidence 0.04 Published 1980 Journal Acta Neuropathol. Section Abstract Doc Link 7435143 Disease Relevance 0.21 Pain Relevance 0.53

Could increased patient age, increased duration of epilepsy or the presence of seizures itself have altered brain plasticity prior to surgery, for example by producing a hypersynchronous condition in the cortex, whereby stimulation would be more likely to activate distant regions?

Regulation (altered) of brain in cortex associated with epilepsy and convulsion

8) Confidence 0.04 Published 2008 Journal Brain Section Body Doc Link PMC2408939 Disease Relevance 0.26 Pain Relevance 0

These results show that widespread dynamic changes in cortical responses can occur in intact cortex within short periods of time, and that the distribution of these responses depends on local brain states and functional brain architecture at the time of stimulation.

Regulation (depends) of brain in brain

9) Confidence 0.04 Published 2008 Journal Brain Section Abstract Doc Link PMC2408939 Disease Relevance 0 Pain Relevance 0

These results show that widespread dynamic changes in cortical responses can occur in intact cortex within short periods of time, and that the distribution of these responses depends on local brain states and functional brain architecture at the time of stimulation.

Regulation (depends) of brain in brain

10) Confidence 0.04 Published 2008 Journal Brain Section Abstract Doc Link PMC2408939 Disease Relevance 0 Pain Relevance 0

This allowed the start of the measurement periods to be closer to the start of stimulation for higher frequencies, which in turn prevented earlier activity that might not have affected the brain's response to stimulation from influencing these measurements.

Neg (not) Spec (might) Regulation (affected) of brain in brain

11) Confidence 0.04 Published 2008 Journal Brain Section Body Doc Link PMC2408939 Disease Relevance 0 Pain Relevance 0

Statistical maps are displayed on the inflated medial cortical surfaces of the template brain at P ?

Regulation (displayed) of brain in medial

12) Confidence 0.04 Published 2008 Journal Brain Section Body Doc Link PMC2525446 Disease Relevance 0 Pain Relevance 0.03

Additional data about correspondence of estradiol-target neuron accumulations with neuronal sites of peptide messenger production suggest direct effects of estradiol on certain enkephalin, endorphin, corticotropin releasing hormone, adrenalin, serotonin, cholecystokinin, pancreatic polypeptide and gonadotropin releasing hormone neurons--and probably others.

Regulation (effects) of adrenalin in neuron associated with enkephalin, cholecystokinin and serotonin

13) Confidence 0.01 Published 1984 Journal Peptides Section Abstract Doc Link 6384951 Disease Relevance 0 Pain Relevance 0.48

If the repetition-rate is held constant while some other variable is changed, then changes in the magnitude of the product at the stimulus repetition-rate may indicate changes in brain activity if the change in the experimental variable causes no changes in the general waveshape (time-domain), but only changes the magnitude of the entire brain response.

Regulation (changes) of brain response in brain

14) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0 Pain Relevance 0

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