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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.25
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FGF1) cytoplasm (FGF1) cytosol (FGF1)
extracellular space (FGF1) signal transduction (FGF1) extracellular region (FGF1)
Anatomy Link Frequency
muscle 2
fibroblast 1
FGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Botox 18 98.32 Very High Very High Very High
Enkephalin 1 98.22 Very High Very High Very High
Inflammation 3 93.92 High High
Pain 6 92.40 High High
Neurotransmitter 2 91.92 High High
Neuropeptide 1 91.72 High High
substance P 3 91.08 High High
Glutamate 1 90.56 High High
Analgesic 1 87.88 High High
Calcitonin gene-related peptide 4 85.20 High High
Disease Link Frequency Relevance Heat
Neurogenic Inflammation 1 93.92 High High
Breast Cancer 43 93.24 High High
Apoptosis 12 92.88 High High
Pain 10 92.40 High High
Nociception 1 88.80 High High
Cancer 53 83.96 Quite High
Death 9 77.20 Quite High
Myofascial Pain Syndromes 1 73.12 Quite High
Metastasis 8 69.24 Quite High
Carcinoma 3 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data on other angiogenic growth factors are limited, but an increase in endothelial cell-stimulating angiogenic growth factor (ESAF) has been observed in response to increased blood flow and muscle stretching.
Positive_regulation (increase) of endothelial cell-stimulating angiogenic growth factor in muscle
1) Confidence 0.38 Published 2001 Journal Front. Biosci. Section Abstract Doc Link 11145922 Disease Relevance 0 Pain Relevance 0.06
Quantitative analysis showed after endothelial induction, ICAM1, CD31, VCAM1, and vWF were significantly upregulated, while FGF1, Flt1, KDR and VEGFA were expressed in undifferentiated cells and upregulated with endothelial differentiation of hESCs (Figure 4B), which were also consistent with the microarray data.
Positive_regulation (upregulated) of FGF1
2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0.05 Pain Relevance 0
Enkephalin gene expression is upregulated after BTX injection into the gastrocnemius muscle, while acidic fibroblast growth factor genes become downregulated.[22] Of all BTX serotypes, BTXA produced the strongest effects.
Positive_regulation (become) of acidic fibroblast growth factor in muscle associated with enkephalin and botox
3) Confidence 0.06 Published 2008 Journal Journal of Cutaneous and Aesthetic Surgery Section Body Doc Link PMC2840887 Disease Relevance 0.84 Pain Relevance 1.27
These include the vascular endothelial growth factor, the platelet-derived endothelial cell growth factor (also known as thymidine phosphorylase), and the fibroblast growth factor family [59].

Positive_regulation (derived) of endothelial cell growth factor in fibroblast
4) Confidence 0.06 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400674 Disease Relevance 1.36 Pain Relevance 0

General Comments

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