INT92971

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 11.30
Pain Relevance 6.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
skin 2
neuronal 1
AtT20 1
nervous system 1
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 328 100.00 Very High Very High Very High
Serotonin 30 100.00 Very High Very High Very High
bDMF 20 100.00 Very High Very High Very High
sSRI 60 99.80 Very High Very High Very High
Somatostatin 18 99.14 Very High Very High Very High
fluoxetine 38 99.08 Very High Very High Very High
gABA 28 98.04 Very High Very High Very High
Potency 10 98.04 Very High Very High Very High
Inflammation 93 97.84 Very High Very High Very High
Arthritis 64 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 31 99.56 Very High Very High Very High
Shock 38 99.16 Very High Very High Very High
Apoptosis 117 98.02 Very High Very High Very High
Arthritis 62 97.84 Very High Very High Very High
Depression 197 97.00 Very High Very High Very High
Cold Sores 52 96.72 Very High Very High Very High
Morphine Dependence 27 96.72 Very High Very High Very High
Neuropathic Pain 44 95.76 Very High Very High Very High
Disease 114 94.80 High High
Death 18 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequent to phosphorylation at Ser133, CRE-bound CREB can exert its influence upon target gene transcription and interact with promoter-bound cofactors.
CREB Binding (interact) of
1) Confidence 0.47 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.05 Pain Relevance 0.06
The transcription factor cAMP-responsive element binding protein (CREB) and its binding site (CRE) have been suggested to play a major role in both the development of depression and antidepressive therapy.


CREB Binding (site) of associated with depression
2) Confidence 0.37 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1855984 Disease Relevance 0.83 Pain Relevance 0.22
The transcription factor cAMP-responsive element binding protein (CREB) and its binding site (CRE) have been suggested to play a major role in both the development of depression and antidepressive therapy.


cAMP-responsive element binding protein Binding (site) of associated with depression
3) Confidence 0.37 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1855984 Disease Relevance 0.83 Pain Relevance 0.22
In another study, topical application of TPA induced DNA binding of cyclic AMP response element binding (CREB) protein in mouse skin in vivo, which was abrogated by pretreatment with either CB or DC.
cyclic AMP response element binding Binding (binding) of in skin
4) Confidence 0.36 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.31 Pain Relevance 0.16
It has been recently shown that mice with a null mutation for Creb restricted to central regions do not show the excessive apoptosis witnessed by peripheral Creb null mutation [63], driving subsequent studies into central-specific CREB recombination, discussed later.


CREB Binding (recombination) of associated with apoptosis
5) Confidence 0.36 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.48 Pain Relevance 0.03
CREB activity cannot be equated with its phosphorylation per se although phosphorylation is a necessary prerequisite for CREB activity as it enables the interaction with the cofactor CBP (CREB binding protein)[9].
CREB Binding (interaction) of
6) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.34 Pain Relevance 0
In previous studies this construct has been characterized thoroughly with respect to its CREB binding affinity and its response to stimuli like cAMP and membrane depolarization[19].
CREB Binding (affinity) of
7) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.58 Pain Relevance 0
Antisense models have also been utilised, involving the local knockdown of CREB by infusion of CREB antisense, which binds to Creb mRNA thus inhibiting further translation.
Creb Binding (binds) of
8) Confidence 0.35 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.07 Pain Relevance 0.07
CREB is a member of a basic leucine zipper (bZIP) CREB/ATF-1 sub-family which includes members CREM (cAMP Responsive Element Modulatory protein) and ATF-1 (Activating Transcription Factor 1), both which bear high bZIP region sequence homology [106], and can bind as homo- or hetero-dimers with these members to the canonical cAMP Responsive Element (CRE) consensus sequence via the leucine zipper in the promoter regions of target genes [11, 22, 61].
CREB Binding (bind) of
9) Confidence 0.35 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.13 Pain Relevance 0.07
Although the extent and kinetics of mCREB dimerisation (with CREB, CREM and ATF-1), CRE-DNA binding and subsequent dimer transcriptional activation potency is not fully known [65], HSV-mCREB overexpression appears to be a promising strategy in the ongoing elucidation of central CREBÂ’s impact in the context of addiction studies.


CREB Binding (binding) of associated with addiction, cold sores and potency
10) Confidence 0.35 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.22 Pain Relevance 0.12
Excision of exon 10 from Creb1 leads to translation of CREB deficient in DNA binding and dimerization functional domains, such that the protein is unstable and thus, there is loss of CREB [68].
CREB Binding (binding) of
11) Confidence 0.35 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.15 Pain Relevance 0
In another study, topical application of TPA induced DNA binding of cyclic AMP response element binding (CREB) protein in mouse skin in vivo, which was abrogated by pretreatment with either CB or DC.
CREB Binding (binding) of in skin
12) Confidence 0.31 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.31 Pain Relevance 0.16
The sequence of the rat somatostatin gene promoter CRE is a well characterized binding site for the transcription factor CREB [19].
factor CREB Binding (binding) of associated with somatostatin
13) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.93 Pain Relevance 0.20
Subsequently, whilst mCREB can still bind to cAMP responsive elements (CREs), it inhibits active CREB by occupying the CRE and preventing access by wild-type CREB and other CRE-binding proteins [98, 106].
mCREB Binding (bind) of
14) Confidence 0.30 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.54 Pain Relevance 0.03
These results, together with our finding that the depolarization-sensitive upstream stimulatory factor (USF) binds to a composite CREB/ATF4/USF regulatory element only in the absence of CREB binding, indicate that selective control of alternative GABA(B)R1 promoters by CREB, ATF4, and USF may dynamically regulate expression of their gene products in the nervous system.
CREB Binding (binding) of in nervous system associated with gaba
15) Confidence 0.30 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15240803 Disease Relevance 0.07 Pain Relevance 0.45
Gel shift and super-shift experiments demonstrate that the transcription factor CREB can bind to both sites and is likely to be responsible for the cAMP-mediated increase in GalR1 promoter activity.
CREB Binding (bind) of
16) Confidence 0.29 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11145992 Disease Relevance 0 Pain Relevance 0.56
In addition, the NO signaling pathway can mediate the expression of CREB target genes by controlling CREB-DNA binding, which is independent of CREB phosphorylation [62].
CREB-DNA Binding (binding) of
17) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.28 Pain Relevance 0.16
CRE binding of CREB is transiently upregulated after kindling stimulation [73].
CREB Binding (binding) of
18) Confidence 0.26 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.94 Pain Relevance 0.23
However, the outcome of CRE-mediated gene transcription does not solely depend on CREB binding, but on the competitive binding of several dimerized transcription factors, including activators and repressors of gene transcription.
CREB Binding (binding) of
19) Confidence 0.26 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0 Pain Relevance 0
Among the mRNA targets of miR-103 was also the transcription factor CREB1 gene, which binds as a homodimer to cAMP responsive elements within the DNA sequence [39].
CREB1 gene Binding (binds) of
20) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0 Pain Relevance 0

General Comments

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