INT92972

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.08
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Galr1) plasma membrane (Galr1) signal transducer activity (Galr1)
Anatomy Link Frequency
brain 2
Galr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 8 99.68 Very High Very High Very High
withdrawal 3 99.40 Very High Very High Very High
opiate 5 98.96 Very High Very High Very High
Dopamine 1 91.20 High High
Substantia nigra 4 87.44 High High
Nucleus accumbens 4 87.12 High High
Ventral tegmentum 4 86.96 High High
addiction 1 77.16 Quite High
Neuropeptide 2 72.60 Quite High
analgesia 1 51.72 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 1 77.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study provides a molecular mechanism for the increased GalR1 expression in the LC seen following opiate withdrawal.
Positive_regulation (increased) of Gene_expression (expression) of GalR1 associated with locus ceruleus, opiate and withdrawal
1) Confidence 0.69 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11145992 Disease Relevance 0 Pain Relevance 0.52
Although the distribution of GalR1, GalR2, and GalR3 largely recapitulates the pattern of galanin binding throughout the brain, some discrepancies exist, suggesting that another galanin receptor(s) may be present in some brain areas.
Positive_regulation (recapitulates) of Gene_expression (distribution) of GalR1 in brain
2) Confidence 0.50 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15514977 Disease Relevance 0.08 Pain Relevance 0.94

General Comments

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