INT9298

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 64
Total Number 67
Disease Relevance 12.29
Pain Relevance 41.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gtpbp4) nucleolus (Gtpbp4) nucleus (Gtpbp4)
GTPase activity (Gtpbp4) ribosome biogenesis (Gtpbp4) cytoplasm (Gtpbp4)
Anatomy Link Frequency
brain 9
hippocampus 3
cerebellum 3
neurons 3
spinal cords 2
Gtpbp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 55 100.00 Very High Very High Very High
agonist 160 99.98 Very High Very High Very High
Neuropathic pain 15 99.96 Very High Very High Very High
Morphine 94 99.84 Very High Very High Very High
ischemia 3 99.84 Very High Very High Very High
Dopamine 30 99.80 Very High Very High Very High
mu opioid receptor 19 99.80 Very High Very High Very High
Neuropeptide 20 99.78 Very High Very High Very High
adenocard 31 99.74 Very High Very High Very High
Peripheral nerve injury 4 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acute Renal Failure 49 100.00 Very High Very High Very High
Neuropathic Pain 80 99.96 Very High Very High Very High
Cv Unclassified Under Development 3 99.84 Very High Very High Very High
Hyperalgesia 45 99.58 Very High Very High Very High
Sprains And Strains 12 99.40 Very High Very High Very High
Nervous System Injury 10 99.28 Very High Very High Very High
INFLAMMATION 35 99.04 Very High Very High Very High
Nociception 24 98.16 Very High Very High Very High
Diabetes Mellitus 73 96.52 Very High Very High Very High
Pain 39 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was also found that the C3 phenolic group is favourable for G-protein activation.
Positive_regulation (activation) of G-protein
1) Confidence 0.69 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12020678 Disease Relevance 0 Pain Relevance 0.42
Furthermore, there was receptor reserve for G-protein activation by some agonists in mMOR-CHO cell membranes, but no receptor reserve was detected in rat thalamic membranes.
Positive_regulation (activation) of G-protein associated with agonist
2) Confidence 0.42 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580589 Disease Relevance 0 Pain Relevance 0.84
This rodent study defines opioid architecture in the perigenual and midcingulate divisions of ACC, relates mu-opioid receptor binding and G-protein activation, and localizes such binding to afferent axons with knife-cut lesions and specifically to noradrenergic terminals with immunotoxin lesions (anti-dopamine beta-hydroxylase-saporin; anti-DBH-saporin). [(3)H]Tyr-D-AlaGly-MePhe-Gly-ol (DAMGO) binding was highest in perigenual areas 32 and 24 with a peak in layer I.
Positive_regulation (activation) of G-protein in ACC associated with dopamine, opioid receptor, anterior cingulate cortex and opioid
3) Confidence 0.36 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11714867 Disease Relevance 0.09 Pain Relevance 0.56
Correlation analysis of receptor and G-protein activation before and after undercut lesions suggested there were a greater number of DAMGO receptor sites for each G-protein on axons, than on somata and proximal dendrites.
Positive_regulation (activation) of G-protein in dendrites
4) Confidence 0.36 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11714867 Disease Relevance 0.05 Pain Relevance 0.46
Because G-protein mediation of opioid effects has been shown in other systems, we tested if the nucleotide requirement for opioid hyperpolarization in SG neurons was due to G-protein activation.
Positive_regulation (activation) of G-protein in neurons associated with substantia gelatinosa and opioid
5) Confidence 0.36 Published 1998 Journal J. Neurophysiol. Section Abstract Doc Link 9862898 Disease Relevance 0 Pain Relevance 0.83
Moreover, the low-affinity potencies for DAMGO in receptor binding and G-protein activation were the same across different regions.
Positive_regulation (activation) of G-protein
6) Confidence 0.35 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10751548 Disease Relevance 0 Pain Relevance 0.44
Morphine produced higher (P < 0.05) maximal stimulation of G-protein in the morphine-withdrawal group (83.60%) compared with the placebo group (66.81%).
Positive_regulation (stimulation) of G-protein associated with withdrawal and morphine
7) Confidence 0.33 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16741068 Disease Relevance 0 Pain Relevance 1.74
The present study investigated the micro-opioid receptor-stimulated G-protein activity using guanylyl 5'-[gamma-[35S]thio]-triphosphate ([35S]-GTPgammaS) autoradiography. [35S]-GTPgammaS binding was performed using coronal rat brain sections (20 microm) in the presence or absence of the micro-opioid selective agonist [D-Ala(2),N-MePhe(4)Gly(5)-ol] enkephalin (DAMGO).
Spec (investigated) Positive_regulation (receptor-stimulated) of G-protein in brain associated with agonist, enkephalin, opioid receptor and opioid
8) Confidence 0.24 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12098584 Disease Relevance 0.18 Pain Relevance 1.01
The present lack of differences between morphine-withdrawn and control rats indicates that micro-opioid receptor-stimulated G-protein activity is not modulated by chronic morphine administration and is not involved in the expression of opiate withdrawal.
Positive_regulation (receptor-stimulated) of G-protein associated with opiate, opioid receptor, withdrawal and morphine
9) Confidence 0.24 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12098584 Disease Relevance 0.38 Pain Relevance 1.64
The responses to 1S,3R-ACPD and quisqualate were reduced by including the G-protein blocker GDP-beta-S (400 microM) in the patch pipette solution by 77 +/- 2% (mean +/- S.E) of control (n = 3), suggesting that these agonists activate a G-protein-coupled receptor.
Positive_regulation (activate) of G-protein associated with agonist
10) Confidence 0.24 Published 1995 Journal Neuroscience Section Abstract Doc Link 8544998 Disease Relevance 0 Pain Relevance 0.34
Differences in G-protein activation by mu- and delta-opioid, and cannabinoid, receptors in rat striatum.
Positive_regulation (activation) of G-protein in striatum associated with cannabinoid and opioid
11) Confidence 0.23 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8831110 Disease Relevance 0 Pain Relevance 0.81
A good correlation existed between ligand binding densities and G-protein activation for mu- and kappa-receptors in control and naloxone-treated brain sections.
Positive_regulation (activation) of G-protein in brain associated with narcan
12) Confidence 0.23 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10551276 Disease Relevance 0 Pain Relevance 1.25
This receptor up-regulation was functional, because receptor coupling to G-protein activation was enhanced by agonist ligands, as revealed by [35S]GTPgammaS autoradiography.
Positive_regulation (activation) of G-protein associated with agonist
13) Confidence 0.23 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10551276 Disease Relevance 0 Pain Relevance 1.21
The degree of decrease in G-protein activation by terbutaline was in harmony with its cervical resistance-increasing action.
Positive_regulation (activation) of G-protein
14) Confidence 0.22 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15645294 Disease Relevance 0.06 Pain Relevance 0.03
Cervical resistance was measured by means of a mechanical stretching test in vitro, the beta(2)-AR density was determined by Western blot analysis, the beta(2)-AR mRNA was determined by RT-PCR, while the G-protein activation following cervical beta(2)-AR stimulation with terbutaline was evaluated via a [(35)S]GTPgammaS binding assay.
Positive_regulation (activation) of G-protein
15) Confidence 0.22 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15645294 Disease Relevance 0.14 Pain Relevance 0.16
The [(35)S]GTPgammaS binding assay demonstrated a decreased G-protein activation on the days of pregnancy investigated, but no activation was found in the nonpregnant samples.
Positive_regulation (activation) of G-protein
16) Confidence 0.22 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15645294 Disease Relevance 0 Pain Relevance 0.03
Further, intracellular application of guanosine-5'-O-(2-thiodiphosphate) (GDP-beta-S; 500 microM), which blocks G-protein activation, abolished the effects of DAMGO.
Positive_regulation (activation) of G-protein
17) Confidence 0.21 Published 1998 Journal J. Neurophysiol. Section Abstract Doc Link 9862898 Disease Relevance 0 Pain Relevance 0.80
The ET(B) agonist, IRL1620, induced G-protein stimulation was similar in placebo (73.43%, EC50 = 13.26 nM) and morphine-withdrawal groups (75.08%, EC(50) = 11.70 nM), respectively.
Positive_regulation (induced) of G-protein associated with agonist, withdrawal and morphine
18) Confidence 0.21 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16741068 Disease Relevance 0 Pain Relevance 1.54
From the results, it is proposed that G-protein activation is an essential component of the bradykinin response, which may also require a Ca(2+)-activated conductance modulated by protein kinase C and lipoxygenase metabolites of arachidonic acid.
Positive_regulation (activation) of G-protein associated with kinase c and bradykinin
19) Confidence 0.19 Published 1992 Journal Neuroscience Section Abstract Doc Link 1407541 Disease Relevance 0.07 Pain Relevance 0.27
Morphine-induced maximal stimulation of G-protein in morphine withdrawal group (83.60%) was significantly higher compared to placebo control group (66.81%).
Positive_regulation (stimulation) of G-protein associated with withdrawal and morphine
20) Confidence 0.17 Published 2006 Journal Peptides Section Abstract Doc Link 16293342 Disease Relevance 0 Pain Relevance 1.80

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox