INT92988

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.48
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Eln) extracellular region (Eln) proteinaceous extracellular matrix (Eln)
extracellular matrix organization (Eln)
Anatomy Link Frequency
blood 1
vasculature 1
plaques 1
skin 1
Eln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 27 99.72 Very High Very High Very High
metalloproteinase 10 98.88 Very High Very High Very High
cva 103 96.96 Very High Very High Very High
cINOD 2 86.96 High High
positron emission tomography 5 80.08 Quite High
fibrosis 1 77.20 Quite High
Pain 32 70.48 Quite High
ischemia 42 64.72 Quite High
imagery 16 25.00 Low Low
Angina 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 29 99.72 Very High Very High Very High
Aneurism 9 98.52 Very High Very High Very High
Alpha-1-antitrypsin Deficiency 12 98.10 Very High Very High Very High
Ulcers 15 97.48 Very High Very High Very High
Abdominal Aortic Aneurysm 13 96.96 Very High Very High Very High
Wound Healing 2 96.80 Very High Very High Very High
Rupture 14 96.32 Very High Very High Very High
Pressure And Volume Under Development 1 96.08 Very High Very High Very High
Hypertension 7 94.52 High High
Duodenal Ulcer 26 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because chronic metalloproteinases production and activation by inflammatory cells causes degradation of elastin and collagen in the aneurysmal wall, the detection of an increased metabolic process preceding fissuration and rupture could be a more sensitive predictor of rupture risk.
Protein_catabolism (degradation) of elastin associated with inflammation, rupture and metalloproteinase
1) Confidence 0.47 Published 2004 Journal Semin Vasc Surg Section Abstract Doc Link 15185180 Disease Relevance 0.79 Pain Relevance 0.22
Chronic inflammation and enzymatic degradation of elastin and collagen constitute the prominent pathogenetic mechanism of infrarenal AAA.
Protein_catabolism (degradation) of elastin associated with inflammation and cva
2) Confidence 0.47 Published 2007 Journal Giornale italiano di cardiologia (2006) Section Abstract Doc Link 17972423 Disease Relevance 1.27 Pain Relevance 0.42
Experimental aortic aneurysm may be evoked in animals by application of chemical compounds disturbing biosynthesis, posttranslating modifications and degradation of elastin and collagen, local damage of the aortic wall by chemical, thermal and mechanical factors and by increased blood pressure.
Protein_catabolism (degradation) of elastin in blood associated with pressure and volume under development and aneurism
3) Confidence 0.21 Published 2000 Journal Postepy Hig Med Dosw Section Abstract Doc Link 11146895 Disease Relevance 0.43 Pain Relevance 0.09
Low levels of A1AT, leading to unopposed neutrophil elastase activity in the vasculature may result in the local degradation of elastin, with a resultant increased collagen deposition.
Protein_catabolism (degradation) of elastin in vasculature associated with alpha-1-antitrypsin deficiency
4) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC3004850 Disease Relevance 1.00 Pain Relevance 0.10
In general, MMP-3 can degrade a wide range of substrates, including fibronectin, type IV, V, IX, and X collagens, elastin, laminins, gelatin, and proteoglycan core proteins, and is thus helpful during wound healing of the skin [27-29].
Protein_catabolism (degrade) of elastin in skin associated with wound healing
5) Confidence 0.02 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC2928200 Disease Relevance 0.89 Pain Relevance 0
The metalloproteinases in particular, expressed by macrophages and smooth muscle cells within plaques, degrade matrix collagen and elastin.
Protein_catabolism (degrade) of elastin in plaques associated with metalloproteinase
6) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922325 Disease Relevance 1.09 Pain Relevance 0.20

General Comments

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