INT9299

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Context Info
Confidence 0.53
First Reported 1983
Last Reported 2006
Negated 3
Speculated 2
Reported most in Abstract
Documents 32
Total Number 35
Disease Relevance 6.65
Pain Relevance 16.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
pituitary 8
endothelial cell 3
muscle 2
spinal cord 2
nucleus 2
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thermal hyperalgesia 30 100.00 Very High Very High Very High
Neuropathic pain 20 100.00 Very High Very High Very High
Spinal cord 9 100.00 Very High Very High Very High
tolerance 11 99.98 Very High Very High Very High
narcan 14 99.96 Very High Very High Very High
Morphine 40 99.78 Very High Very High Very High
antagonist 9 99.78 Very High Very High Very High
local anesthetic 8 99.78 Very High Very High Very High
Neurotransmitter 7 99.60 Very High Very High Very High
Opioid 15 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 30 100.00 Very High Very High Very High
Neuropathic Pain 20 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 9 100.00 Very High Very High Very High
Nociception 10 98.84 Very High Very High Very High
Vibrio Infection 5 98.80 Very High Very High Very High
Stress Incontinence 4 97.40 Very High Very High Very High
Hypoglycemia 2 87.96 High High
Cv General 3 Under Development 2 84.48 Quite High
Opiate Addiction 2 82.64 Quite High
Bordatella Infection 4 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the acute nociceptive effects of N-methyl-D-aspartate have been reported to be mediated through production of nitric oxide and activation of soluble guanylate cyclase, these experiments were designed to determine whether the thermal hyperalgesia produced in a rat model of neuropathic pain is also mediated through the production of nitric oxide and activation of soluble guanylate cyclase.
Positive_regulation (mediated) of Positive_regulation (activation) of cyclase associated with nociception, thermal hyperalgesia and neuropathic pain
1) Confidence 0.53 Published 1992 Journal Neuroscience Section Abstract Doc Link 1407561 Disease Relevance 0.84 Pain Relevance 0.84
The nitrite-elicited relaxation depends on activation of guanylate cyclase and high conductance Ca2+-activated potassium channels; however, activation of potassium channels might be a part of or might act in parallel with the mechanism involving the cyclic GMP system.
Positive_regulation (depends) of Positive_regulation (activation) of guanylate cyclase associated with potassium channel
2) Confidence 0.50 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 10100881 Disease Relevance 0 Pain Relevance 0.16
The local anesthetics appear to exert their inhibitory effect on endothelium-dependent vasodilation at a site distal to receptor activation at the endothelial cell and proximal to guanylate cyclase activation in the vascular smooth muscle.
Spec (appear) Positive_regulation (exert) of Positive_regulation (activation) of cyclase in endothelial cell associated with increased venous pressure under development and local anesthetic
3) Confidence 0.40 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2719315 Disease Relevance 0.33 Pain Relevance 0.40
Nitric oxide activates guanylate cyclase, resulting in an accumulation of cyclic GMP.
Positive_regulation (resulting) of Positive_regulation (activates) of guanylate cyclase
4) Confidence 0.38 Published 1991 Journal Nurs. Clin. North Am. Section Abstract Doc Link 1904576 Disease Relevance 0.31 Pain Relevance 0.11
As the acute nociceptive effects of N-methyl-D-aspartate have been reported to be mediated through production of nitric oxide and activation of soluble guanylate cyclase, these experiments were designed to determine whether the thermal hyperalgesia produced in a rat model of neuropathic pain is also mediated through the production of nitric oxide and activation of soluble guanylate cyclase.
Positive_regulation (mediated) of Positive_regulation (activation) of cyclase associated with nociception, thermal hyperalgesia and neuropathic pain
5) Confidence 0.38 Published 1992 Journal Neuroscience Section Abstract Doc Link 1407561 Disease Relevance 0.84 Pain Relevance 0.84
As the acute nociceptive effects of N-methyl-D-aspartate have been reported to be mediated through production of nitric oxide and activation of soluble guanylate cyclase, these experiments were designed to determine whether the thermal hyperalgesia produced in a rat model of neuropathic pain is also mediated through the production of nitric oxide and activation of soluble guanylate cyclase.
Positive_regulation (through) of Positive_regulation (activation) of cyclase associated with nociception, thermal hyperalgesia and neuropathic pain
6) Confidence 0.38 Published 1992 Journal Neuroscience Section Abstract Doc Link 1407561 Disease Relevance 0.84 Pain Relevance 0.84
As the acute nociceptive effects of N-methyl-D-aspartate have been reported to be mediated through production of nitric oxide and activation of soluble guanylate cyclase, these experiments were designed to determine whether the thermal hyperalgesia produced in a rat model of neuropathic pain is also mediated through the production of nitric oxide and activation of soluble guanylate cyclase.
Positive_regulation (mediated) of Positive_regulation (activation) of cyclase associated with nociception, thermal hyperalgesia and neuropathic pain
7) Confidence 0.38 Published 1992 Journal Neuroscience Section Abstract Doc Link 1407561 Disease Relevance 0.71 Pain Relevance 0.73
These results suggest that a sustained production of nitric oxide and subsequent activation of soluble guanylate cyclase in the lumbar spinal cord mediate the thermal hyperalgesia produced in a model of neuropathic pain in the rat.
Positive_regulation (mediate) of Positive_regulation (activation) of cyclase in spinal cord associated with thermal hyperalgesia, neuropathic pain and spinal cord
8) Confidence 0.38 Published 1992 Journal Neuroscience Section Abstract Doc Link 1407561 Disease Relevance 0.92 Pain Relevance 0.97
Using specific radioimmunoassays for pituitary adenylate cyclase activating peptide-38, pituitary adenylate cyclase activating peptide-27 and pituitary adenylate cyclase activating peptide-related peptide we found that all three pituitary adenylate cyclase activating peptide-precursor-derived peptides were present in tissue extracts from the ureter, the urinary bladder and the urethra.
Positive_regulation (activating) of Positive_regulation (activating) of cyclase in pituitary associated with stress incontinence
9) Confidence 0.16 Published 1998 Journal Neuroscience Section Abstract Doc Link 9502264 Disease Relevance 0.09 Pain Relevance 0.07
Using specific radioimmunoassays for pituitary adenylate cyclase activating peptide-38, pituitary adenylate cyclase activating peptide-27 and pituitary adenylate cyclase activating peptide-related peptide we found that all three pituitary adenylate cyclase activating peptide-precursor-derived peptides were present in tissue extracts from the ureter, the urinary bladder and the urethra.
Positive_regulation (present) of Positive_regulation (activating) of cyclase in pituitary associated with stress incontinence
10) Confidence 0.16 Published 1998 Journal Neuroscience Section Abstract Doc Link 9502264 Disease Relevance 0.10 Pain Relevance 0.07
Using specific radioimmunoassays for pituitary adenylate cyclase activating peptide-38, pituitary adenylate cyclase activating peptide-27 and pituitary adenylate cyclase activating peptide-related peptide we found that all three pituitary adenylate cyclase activating peptide-precursor-derived peptides were present in tissue extracts from the ureter, the urinary bladder and the urethra.
Positive_regulation (pituitary) of Positive_regulation (activating) of cyclase in pituitary associated with stress incontinence
11) Confidence 0.16 Published 1998 Journal Neuroscience Section Abstract Doc Link 9502264 Disease Relevance 0.09 Pain Relevance 0.07
Using specific radioimmunoassays for pituitary adenylate cyclase activating peptide-38, pituitary adenylate cyclase activating peptide-27 and pituitary adenylate cyclase activating peptide-related peptide we found that all three pituitary adenylate cyclase activating peptide-precursor-derived peptides were present in tissue extracts from the ureter, the urinary bladder and the urethra.
Positive_regulation (activating) of Positive_regulation (activating) of cyclase in pituitary associated with stress incontinence
12) Confidence 0.16 Published 1998 Journal Neuroscience Section Abstract Doc Link 9502264 Disease Relevance 0.09 Pain Relevance 0.07
These data suggest that the switch to Gs coupling by MOR in response to chronic morphine, which is attenuated by ultra-low-dose opioid antagonist cotreatment, leads to a two-pronged stimulation of adenylyl cyclase utilizing both Galpha and Gbetagamma subunits of the Gs protein novel to this receptor.
Positive_regulation (leads) of Positive_regulation (stimulation) of cyclase associated with antagonist, mu opioid receptor, opioid and morphine
13) Confidence 0.15 Published 2006 Journal J. Neurobiol. Section Abstract Doc Link 16967511 Disease Relevance 0 Pain Relevance 1.19
These data suggest that the switch to Gs coupling by MOR in response to chronic morphine, which is attenuated by ultra-low-dose opioid antagonist cotreatment, leads to a two-pronged stimulation of adenylyl cyclase utilizing both Galpha and Gbetagamma subunits of the Gs protein novel to this receptor.
Positive_regulation (stimulation) of Positive_regulation (utilizing) of cyclase associated with antagonist, mu opioid receptor, opioid and morphine
14) Confidence 0.15 Published 2006 Journal J. Neurobiol. Section Abstract Doc Link 16967511 Disease Relevance 0 Pain Relevance 1.17
The local anesthetics appear to exert their inhibitory effect on endothelium-dependent vasodilation at a site distal to receptor activation at the endothelial cell and proximal to guanylate cyclase activation in the vascular smooth muscle.
Spec (appear) Positive_regulation (exert) of in proximal Positive_regulation (activation) of cyclase in endothelial cell associated with increased venous pressure under development and local anesthetic
15) Confidence 0.14 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2719315 Disease Relevance 0.33 Pain Relevance 0.40
Stimulation of adenylate cyclase by PMA is markedly reduced following EGTA treatment, is not observed when adenyl-5'-yl-imidodiphosphate is substituted for ATP as substrate for adenylate cyclase, and is enhanced by L-alpha-phosphatidyl-L-serine.
Neg (not) Positive_regulation (enhanced) of Positive_regulation (Stimulation) of cyclase
16) Confidence 0.11 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 3734803 Disease Relevance 0.08 Pain Relevance 0.18
Therefore, the contractile responses of the rat anococcygeus muscle to MkTx I can be attributed to the release of transmitter NA on postjunctional alpha-adrenoceptors, whereas the relaxant responses of the Acm to MkTx I involve the release of nitric oxide as the neurotransmitter which, presumably, results in the activation of the enzyme guanylate cyclase leading to relaxation of the muscle.
Positive_regulation (results) of Positive_regulation (activation) of guanylate cyclase in muscle associated with neurotransmitter and noradrenaline
17) Confidence 0.10 Published 1997 Journal J Auton Pharmacol Section Abstract Doc Link 9234083 Disease Relevance 0 Pain Relevance 0.29
Procaine treatment increased the glucagon and fluoride activation of the cyclase and the stimulation was concentration-dependent; this compound seemed to act at the G/F unit level since changes in the glucagon binding were not observed and the basal activity was not modified.
Positive_regulation (increased) of Positive_regulation (activation) of cyclase
18) Confidence 0.08 Published 1983 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6309252 Disease Relevance 0 Pain Relevance 0.09
Two possibilities exist: either cGMP accumulates in the preganglionic nerves or a noncholinergic, nonadrenergic transmitter activates guanylate cyclase in postsynaptic structures.
Positive_regulation (accumulates) of Positive_regulation (activates) of cyclase in nerves
19) Confidence 0.08 Published 1983 Journal Fed. Proc. Section Abstract Doc Link 6138282 Disease Relevance 0 Pain Relevance 0.11
In contrast, cAMP production induced via direct activation of the catalytic unit of adenylate cyclase with forskolin was not changed upon long-term morphine treatment, although DAGO strongly inhibited the effect of forskolin.
Positive_regulation (induced) of Positive_regulation (activation) of cyclase associated with enkephalin and morphine
20) Confidence 0.06 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1686867 Disease Relevance 0 Pain Relevance 1.29

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