INT92990

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.42
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Mthfr)
Mthfr (Mus musculus)
Mthfr - C677T (1)
Pain Link Frequency Relevance Heat
methotrexate 5 97.40 Very High Very High Very High
tolerance 1 94.44 High High
alcohol 3 82.36 Quite High
anesthesia 1 60.48 Quite High
Spinal cord 3 55.96 Quite High
cytokine 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
cryotherapy 4 5.00 Very Low Very Low Very Low
analgesia 3 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomatitis 51 98.84 Very High Very High Very High
Recurrence 1 97.88 Very High Very High Very High
Congenital Anomalies 6 92.04 High High
Genetic Predisposition To Disease 1 89.32 High High
Disease 5 87.24 High High
Mucositis 49 85.36 High High
Xerostomia 4 78.76 Quite High
Malignant Neoplastic Disease 4 77.32 Quite High
Spina Bifida 6 75.00 Quite High
Exencephaly /

Neural Tube Defects

1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study of folate and its association with NTDs is an ongoing endeavor that has led to numerous studies of different genes involved in the folate metabolism pathway, including the most commonly studied thermolabile mutation (C677T) in the MTHFR gene.
MTHFR gene (C677T) Binding (association) of
1) Confidence 0.37 Published 2000 Journal Curr Probl Pediatr Section Abstract Doc Link 11147289 Disease Relevance 1.23 Pain Relevance 0.11
For instance, Ulrich et al (2001) reported that in patients undergoing HDC for HSCT, a polymorphism in the 5, 10-methylenetetrahydrofolate reductase gene was associated with a differential rate of oral mucositis after treatment with methotrexate.
methylenetetrahydrofolate reductase Binding (associated) of associated with stomatitis and methotrexate
2) Confidence 0.36 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 1.12 Pain Relevance 0.14

General Comments

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