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Context Info
Confidence 0.15
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.34
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SFTPA1, CD40) signal transduction (CD40) extracellular space (SFTPA1)
plasma membrane (CD40) enzyme binding (CD40) protein complex assembly (CD40)
SFTPA1 (Homo sapiens)
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 8 100.00 Very High Very High Very High
Inflammation 2 88.48 High High
qutenza 1 87.24 High High
Neuropeptide 3 86.20 High High
Inflammatory response 2 59.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 75.00 Quite High
Adhesions 3 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies indicate that SP-induced cellular Ca+2 signals led to the activation of the NF-kappaB pathway, resulting in nuclear translocation of p65/p50 heterodimers that bind to high-affinity tandem kappaB sites on the VCAM-1 promoter, whereas SP activation induced NF-AT activation and ICAM-1 DNA binding.
Positive_regulation (activation) of SP Positive_regulation (resulting) of Localization (translocation) of p50 associated with substance p
1) Confidence 0.15 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.34 Pain Relevance 0.61

General Comments

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