INT93001

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.97
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
platelets 1
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 8 98.00 Very High Very High Very High
cytokine 153 94.96 High High
agonist 12 94.92 High High
Inflammation 94 94.56 High High
qutenza 1 86.40 High High
Neuropeptide 3 85.36 High High
Inflammatory response 9 82.96 Quite High
rheumatoid arthritis 56 76.64 Quite High
cva 6 71.84 Quite High
antagonist 14 45.88 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 100 94.56 High High
Apoptosis 43 90.68 High High
Injury 6 79.36 Quite High
Osteoporosis 8 78.12 Quite High
Rheumatoid Arthritis 56 76.64 Quite High
Cancer 174 75.76 Quite High
Adhesions 5 72.76 Quite High
Cv General 3 Under Development 4 71.84 Quite High
Coagulation Disorder 2 64.84 Quite High
Thrombosis 3 60.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies indicate that SP-induced cellular Ca+2 signals led to the activation of the NF-kappaB pathway, resulting in nuclear translocation of p65/p50 heterodimers that bind to high-affinity tandem kappaB sites on the VCAM-1 promoter, whereas SP activation induced NF-AT activation and ICAM-1 DNA binding.
Localization (translocation) of p50 associated with substance p
1) Confidence 0.78 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.33 Pain Relevance 0.60
degradation to release p50/RelA and p50/c-Rel heterodimers and via the alternative or noncanonical pathway by promoting p100 processing into p52 [31].
Localization (release) of p50
2) Confidence 0.73 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.22 Pain Relevance 0.04
degradation to release p50/RelA and p50/c-Rel heterodimers and via the alternative or noncanonical pathway by promoting p100 processing into p52 [31].
Localization (release) of p50
3) Confidence 0.73 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.22 Pain Relevance 0.04
or CD40) stimulates secretion of the bioactive, heterodimeric form of IL-12 (i.e., IL-12p70) and ATP?
Localization (secretion) of CD40
4) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.26
In addition, the platelets release the CD40L protein, a potent proinflammatory mediator, which subsequently induces tissue factor synthesis [68,69] and amplifies the secretion of proinflammatory cytokines [70,71].
Localization (release) of CD40L protein in platelets associated with cytokine
5) Confidence 0.01 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 1.21 Pain Relevance 0.51

General Comments

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