INT93003

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 20.25
Pain Relevance 7.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
Anatomy Link Frequency
B cells 5
macrophages 2
T-cells 2
lymph nodes 1
nucleus 1
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 366 99.32 Very High Very High Very High
agonist 34 99.04 Very High Very High Very High
rheumatoid arthritis 245 98.92 Very High Very High Very High
chemokine 46 98.74 Very High Very High Very High
metalloproteinase 21 98.36 Very High Very High Very High
Inflammatory marker 12 97.96 Very High Very High Very High
cytokine 328 97.64 Very High Very High Very High
substance P 8 97.58 Very High Very High Very High
Arthritis 402 88.96 High High
tolerance 40 88.48 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 8 99.50 Very High Very High Very High
INFLAMMATION 419 99.32 Very High Very High Very High
Malignant Neoplastic Disease 35 98.96 Very High Very High Very High
Rheumatoid Arthritis 259 98.92 Very High Very High Very High
Mantle-cell Lymphoma 34 98.28 Very High Very High Very High
Increased Venous Pressure Under Development 16 98.24 Very High Very High Very High
Adhesions 42 97.56 Very High Very High Very High
Apoptosis 139 97.32 Very High Very High Very High
Systemic Lupus Erythematosus 164 96.30 Very High Very High Very High
Renal Disease 21 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Increasing evidence indicates that the CD40-CD40L interaction plays a pivotal role in the inflammatory regulation of atherosclerosis.
CD40 Binding (interaction) of associated with inflammation, increased venous pressure under development and adhesions
1) Confidence 0.47 Published 2002 Journal Clin. Chim. Acta Section Abstract Doc Link 11922919 Disease Relevance 0.86 Pain Relevance 0.20
Although B cell activation can occur independently of T cell help in lupus, a substantial fraction of B cells is activated in a T cell dependent manner [8-10], as demonstrated by isotype switching and affinity maturation of B cells [11,12] and enhanced CD154-CD40 interactions [13].
CD40 Binding (interactions) of in B cells associated with systemic lupus erythematosus
2) Confidence 0.47 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526638 Disease Relevance 1.12 Pain Relevance 0.15
B p65-p50 heterodimers enter the nucleus, bind to NF-?
p50 Binding (bind) of in nucleus
3) Confidence 0.47 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.47 Pain Relevance 0.33
Phipps [16] summarized the data reported when fibroblast CD40 ligation occurs, resulting in upregulation of cyclo-oxygenase-2 and various cytokines that are characteristic of a T-helper-2-like environment [16], which is known to be preferential to a fibrogenic response [17,18].
CD40 Binding (ligation) of in fibroblast associated with cytokine
4) Confidence 0.40 Published 2002 Journal Respir Res Section Body Doc Link PMC64807 Disease Relevance 1.11 Pain Relevance 0.58
Our studies indicate that SP-induced cellular Ca+2 signals led to the activation of the NF-kappaB pathway, resulting in nuclear translocation of p65/p50 heterodimers that bind to high-affinity tandem kappaB sites on the VCAM-1 promoter, whereas SP activation induced NF-AT activation and ICAM-1 DNA binding.
p50 Binding (bind) of associated with substance p
5) Confidence 0.35 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.33 Pain Relevance 0.57
We found no significant association with the SNPs in the MMEL, CDK6, CCL21 or the CD40 genes, which may suggest that these genes are RA-specific loci.
CD40 Neg (no) Binding (association) of associated with rheumatoid arthritis
6) Confidence 0.33 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.90 Pain Relevance 0.45
The SNP lies in intron 2 of the CD40 gene.20
CD40 Binding (intron) of
7) Confidence 0.33 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.60 Pain Relevance 0.30
well as agonistically binding to CD40 [80].
CD40 Binding (binding) of
8) Confidence 0.26 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.57 Pain Relevance 0.06
Preliminary clinical results with CD40 pathway targeting
CD40 Binding (results) of
9) Confidence 0.22 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.15 Pain Relevance 0.04
CD40 ligation could protect normal and malignant B cells from PPAR?
CD40 Binding (ligation) of in B cells associated with malignant neoplastic disease
10) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.36 Pain Relevance 0.04
Activated T-cells expressing CD154 can also interact with CD40 on endothelial cells to induce production of inflammatory cytokines [14].
CD40 Binding (interact) of in T-cells associated with inflammation and cytokine
11) Confidence 0.21 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.25 Pain Relevance 0.54
Blocking CD40 on synovial fibroblasts from RA patients with soluble anti-CD40 antibodies prior to co-culture with synovial mononuclear cells resulted in decreased TNF?
CD40 Binding (Blocking) of in mononuclear cells associated with rheumatoid arthritis
12) Confidence 0.21 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.72 Pain Relevance 0.76
CD40 interacts with CD40 ligand (CD40L or CD154) which is predominantly expressed on activated CD4+ T-cells [12].
CD40 Binding (interacts) of in T-cells
13) Confidence 0.21 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.26 Pain Relevance 0.59
In addition, ligation of CD40 expressed by macrophages increases the production of matrix-degrading proteases.
CD40 Binding (ligation) of in macrophages
14) Confidence 0.20 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.48 Pain Relevance 0.19
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
CD40 Spec (clear) Binding (levels) of in CD86
15) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.60 Pain Relevance 0.03
Kyburz et al (1999) conducted experiments in a transgenic animal model suggesting overactivity of the CD40–CD40L system may occur in RA (Kyburz et al 1999).
CD40 Binding (overactivity) of associated with targeted disruption and rheumatoid arthritis
16) Confidence 0.18 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.50 Pain Relevance 0.21
CD4+ T cells improve the capacity of DCs to induce CTLs by the interaction between CD40 on DCs and CD40 ligand on activated CD4+ T cells.
CD40 Binding (interaction) of in CTLs
17) Confidence 0.18 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 1.14 Pain Relevance 0.08
On engagement of T and B cells, the T cell becomes activated and expresses CD40L, which in turn binds CD40 on the B cell, initiating the process of somatic hypermutation of the immunoglobulin gene and class switching.
CD40 Binding (binds) of in B cell
18) Confidence 0.18 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.67 Pain Relevance 0.34
In a subset of this cohort, blockade of CD40 ligand with BG9588 markedly increased the frequency of IgG-producing B cells and IgG anti-DNA antibody producing B cells in the peripheral blood of treated patients.
CD40 Binding (ligand) of in blood
19) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.66 Pain Relevance 0.06
Furthermore, an anti-CD154 antibody, IDEC-131 (a humanized antibody that blocks CD40-CD154 interactions [31]), was well tolerated in a phase II study conducted in 85 patients with mild-to-moderate SLE [32]; however, it failed to meet the primary efficacy end-point, namely a reduction in SLEDAI score at 20 weeks after six infusions of IDEC-131 ranging from 2.5 to 10 mg/kg.
CD40 Binding (interactions) of associated with systemic lupus erythematosus
20) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.69 Pain Relevance 0.06

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