INT93005

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Context Info
Confidence 0.68
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.55
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
monocyte 4
vascular endothelium 4
leukocytes 2
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 16 99.76 Very High Very High Very High
Inflammation 102 92.32 High High
Inflammatory response 40 89.28 High High
Neuropeptide 6 89.28 High High
qutenza 2 81.16 Quite High
Nicotine 20 76.80 Quite High
cytokine 4 17.04 Low Low
transdermal 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
nerve block 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 226 100.00 Very High Very High Very High
Nicotine Addiction 368 98.58 Very High Very High Very High
INFLAMMATION 144 89.28 High High
Increased Venous Pressure Under Development 32 67.80 Quite High
Cv Unclassified Under Development 20 54.24 Quite High
Reperfusion Injury 12 33.64 Quite Low
Stroke 2 27.44 Quite Low
Acute Coronary Syndrome 2 26.96 Quite Low
Chronic Obstructive Pulmonary Disease 44 9.84 Low Low
Disease 54 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that smoking may lead to increased monocyte-HUVEC adhesion by influencing an endothelial Mac-1 ligand, with ICAM-1 the prime candidate, or that smoking may induce conformational, or other, alterations to Mac-1, leading to increased affinity for ICAM-1.
Positive_regulation (increased) of ICAM-1 Binding (affinity) of in monocyte associated with nicotine addiction and adhesions
1) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.07 Pain Relevance 0.07
This indicates that smoking may lead to increased monocyte-HUVEC adhesion by influencing an endothelial Mac-1 ligand, with ICAM-1 the prime candidate, or that smoking may induce conformational, or other, alterations to Mac-1, leading to increased affinity for ICAM-1.
Positive_regulation (increased) of ICAM-1 Binding (affinity) of in monocyte associated with nicotine addiction and adhesions
2) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.07 Pain Relevance 0.07
Our studies indicate that SP-induced cellular Ca+2 signals led to the activation of the NF-kappaB pathway, resulting in nuclear translocation of p65/p50 heterodimers that bind to high-affinity tandem kappaB sites on the VCAM-1 promoter, whereas SP activation induced NF-AT activation and ICAM-1 DNA binding.
Positive_regulation (induced) of ICAM-1 Binding (binding) of associated with substance p
3) Confidence 0.47 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.26 Pain Relevance 0.50
After exposure to SP, DMEC expressed significant levels of both intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which was accompanied by increased binding to leukocytes expressing the appropriate integrin counter receptors for these CAM.
Positive_regulation (increased) of ICAM-1 Binding (binding) of in leukocytes associated with adhesions and substance p
4) Confidence 0.47 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.52 Pain Relevance 0.61
This adhesion molecule on the cell surface of phagocytic leukocytes may bind to counter-receptors, such as intercellular adhesion molecule-1 (ICAM-1), present on the surface of vascular endothelium.
Positive_regulation (present) of ICAM-1 Binding (bind) of in vascular endothelium associated with adhesions
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.81 Pain Relevance 0.08
This adhesion molecule on the cell surface of phagocytic leukocytes may bind to counter-receptors, such as intercellular adhesion molecule-1 (ICAM-1), present on the surface of vascular endothelium.
Positive_regulation (present) of adhesion molecule-1 Binding (intercellular) of in vascular endothelium associated with adhesions
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.81 Pain Relevance 0.08

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