INT93016

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 19.67
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11A) cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
osteoclasts 8
macrophage 2
osteoblasts 2
T lymphocytes 2
monocyte 1
TNFRSF11A (Homo sapiens)
TNFRSF11A - R265H (1)
Pain Link Frequency Relevance Heat
cytokine 119 100.00 Very High Very High Very High
Inflammation 217 99.78 Very High Very High Very High
Arthritis 104 99.70 Very High Very High Very High
mu opioid receptor 14 99.52 Very High Very High Very High
aspirin 12 99.04 Very High Very High Very High
rheumatoid arthritis 353 98.48 Very High Very High Very High
Etanercept 6 98.14 Very High Very High Very High
dexamethasone 7 95.60 Very High Very High Very High
Pain 40 95.16 Very High Very High Very High
addiction 7 93.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 213 99.96 Very High Very High Very High
Bone Disease 11 99.96 Very High Very High Very High
Arthritis 30 99.70 Very High Very High Very High
Metastasis 299 99.36 Very High Very High Very High
Osteoporosis 502 99.28 Very High Very High Very High
Cancer 362 99.24 Very High Very High Very High
Rheumatoid Arthritis 355 98.48 Very High Very High Very High
Bone Cancer 34 97.64 Very High Very High Very High
Giant Cell Granuloma 24 96.96 Very High Very High Very High
Giant Cell Tumors 91 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the context of a chronic inflammatory reaction, RANK-L/RANK interactions between T lymphocytes and dendritic cells and between T lymphocytes and osteoclasts explain the role of T cells in disease progression [17,24,32].
RANK Binding (interactions) of in T lymphocytes associated with inflammation and disease progression
1) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.65 Pain Relevance 0.25
In the context of a chronic inflammatory reaction, RANK-L/RANK interactions between T lymphocytes and dendritic cells and between T lymphocytes and osteoclasts explain the role of T cells in disease progression [17,24,32].
RANK Binding (interactions) of in T lymphocytes associated with inflammation and disease progression
2) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.65 Pain Relevance 0.25
Expression of RANK-L, OPG, and RANK proteins by SF neutrophils from patients with RA
RANK Binding (proteins) of in neutrophils associated with rheumatoid arthritis
3) Confidence 0.37 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.46 Pain Relevance 0.23
OPG is a soluble decoy RANK receptor, secreted by osteoblasts, that binds surface RANK ligand (RANKL) on osteoblasts.
RANK Binding (ligand) of in osteoblasts
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958849 Disease Relevance 0.34 Pain Relevance 0.08
Bisphosphonates and RANK ligand inhibitors for the treatment and prevention of metastatic bone disease.
RANK Binding (ligand) of associated with bone cancer
5) Confidence 0.36 Published 2010 Journal Eur. J. Cancer Section Title Doc Link 20347292 Disease Relevance 1.03 Pain Relevance 0.09
T lymphocytes, for instance, promote bone loss in inflammatory arthritis by expressing RANK-L that directly binds and activates osteoclasts [24].
RANK Binding (binds) of in osteoclasts associated with inflammation and arthritis
6) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.79 Pain Relevance 0.24
It acts by binding to RANK expressed on osteoclast precursors stimulating their differentiation into mature osteoclasts.
RANK Binding (binding) of in osteoclast
7) Confidence 0.29 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686344 Disease Relevance 0.46 Pain Relevance 0
OPG is a negative regulator of the RANK/RANKL pathway and prevents RANK-RANKL interaction by sequestering RANKL.
RANK Binding (interaction) of
8) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 0.76 Pain Relevance 0.04
RANK-RANKL interaction in the presence of macrophage colony-stimulating factor activates multiple intracellular signaling cascades (nuclear factor-?
RANK Binding (interaction) of in macrophage
9) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 0.69 Pain Relevance 0
A prior study in our laboratory using a mouse intratibial injection model of metastasis demonstrated that blocking the RANK-RANKL interaction by RANK-Fc (a recombinant soluble fusion protein consisting of extracellular domain of RANK coupled with the Fc domain of human IgG) limits the formation of osteolytic bone lesions [44].
RANK Binding (interaction) of associated with metastasis
10) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.32 Pain Relevance 0.04
Factors recognized to be responsible for these effects are various cytokines and GC use, especially via the RANK-RANKL-OPG system.
RANK Binding (recognized) of associated with cytokine
11) Confidence 0.20 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2768686 Disease Relevance 1.89 Pain Relevance 0.10
Factors such as monocyte colony stimulating factor (m-CSF) and RANK ligand, which are important for osteoclastogenesis and for fusion of monocytes to form multinucleated giant cells, are expressed in giant cell tumors of bone[9].
RANK Binding (ligand) of in monocyte associated with giant cell tumors
12) Confidence 0.19 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2954972 Disease Relevance 0.70 Pain Relevance 0
In the context of a chronic inflammatory reaction, RANK-L/RANK interactions between T lymphocytes and dendritic cells and between T lymphocytes and osteoclasts explain the role of T cells in disease progression [17,24,32].
RANK Binding (interactions) of in osteoclasts associated with inflammation and disease progression
13) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.65 Pain Relevance 0.25
In the context of a chronic inflammatory reaction, RANK-L/RANK interactions between T lymphocytes and dendritic cells and between T lymphocytes and osteoclasts explain the role of T cells in disease progression [17,24,32].
RANK Binding (interactions) of in osteoclasts associated with inflammation and disease progression
14) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.65 Pain Relevance 0.25
RANKL, in turn, binds to its receptor, RANK, on osteoclast lineage cells.
RANK Binding (receptor) of in osteoclast
15) Confidence 0.15 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074710 Disease Relevance 0.62 Pain Relevance 0
The osteoblasts also produce OPG which functions as a decoy receptor and binds RANKL and thereby prevents it from binding to RANK [2,7].
RANK Binding (binding) of in osteoblasts
16) Confidence 0.15 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.49 Pain Relevance 0
This antibody, named denosumab, has been shown to specifically bind to RANKL with a very high affinity, preventing its interaction with the receptor RANK.
RANK Binding (interaction) of
17) Confidence 0.10 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.61 Pain Relevance 0
RANKL stimulates osteoclastogenesis and osteoclast function by binding to the cell surface RANK located on osteoclast precursors and osteoclasts – the interaction necessary for the formation of osteoclasts, osteoclast survival, and bone resorption [35-37].
RANK Binding (binding) of in osteoclast associated with hypercalcemia
18) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.40 Pain Relevance 0.03
Familial Paget's disease of bone: nonlinkage to the PDB1 and PDB2 loci on chromosomes 6p and 18q in a large pedigree.
PDB2 Binding (nonlinkage) of associated with bone disease
19) Confidence 0.06 Published 2001 Journal J. Bone Miner. Res. Section Title Doc Link 11149487 Disease Relevance 0.86 Pain Relevance 0.10
The RANK ligand (RANKL) and a regulatory protein, osteoprotegerin, produced by stromal cells both bind RANK.
RANK Binding (bind) of in stromal cells
20) Confidence 0.05 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2905716 Disease Relevance 1.05 Pain Relevance 0.04

General Comments

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