INT93033

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 0
Speculated 5
Reported most in Body
Documents 48
Total Number 55
Disease Relevance 20.94
Pain Relevance 28.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal cord 3
spike 2
dendrites 1
cleavage 1
caudate putamen 1
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 383 100.00 Very High Very High Very High
ischemia 165 100.00 Very High Very High Very High
long-term potentiation 1637 99.84 Very High Very High Very High
withdrawal 76 99.72 Very High Very High Very High
Dorsal horn 94 99.68 Very High Very High Very High
cerebral cortex 11 99.68 Very High Very High Very High
allodynia 147 99.52 Very High Very High Very High
Pain 90 99.44 Very High Very High Very High
Morphine 13 99.42 Very High Very High Very High
nMDA receptor 839 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Brain Hemorrhage 114 100.00 Very High Very High Very High
Neuropathic Pain 160 99.52 Very High Very High Very High
Pain 170 99.44 Very High Very High Very High
INFLAMMATION 258 99.12 Very High Very High Very High
Depression 879 98.86 Very High Very High Very High
Anxiety Disorder 680 98.80 Very High Very High Very High
Nociception 284 98.56 Very High Very High Very High
Hyperalgesia 159 98.24 Very High Very High Very High
Stress 46 97.92 Very High Very High Very High
Injury 181 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: The NR2B peptide could be used as a vaccine against neuropathic pain, which could be associated with reduction of NR2B protein in the lumbar spinal cord.


Negative_regulation (reduction) of NR2B protein in spinal cord
1) Confidence 0.58 Published 2007 Journal Chin. Med. J. Section Body Doc Link 17517177 Disease Relevance 0 Pain Relevance 0
This might indicate that the suppression of NR2B is used to compensate for the enhanced nociceptive barrage.
Negative_regulation (suppression) of NR2B associated with nociception
2) Confidence 0.54 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.75 Pain Relevance 0.52
The temporal association of thermal hyperalgesia with NR1 phosphorylation while recovery of mechanical allodynia is correlated with the suppression of NR2B suggests that the two behavioral phenomena have distinct mechanisms.
Negative_regulation (suppression) of NR2B associated with allodynia and thermal hyperalgesia
3) Confidence 0.54 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 1.10 Pain Relevance 0.91
Next, we examined the effect of NR2B inhibition on LTP induced by pairing protocol (Figure 2A).
Spec (examined) Negative_regulation (inhibition) of NR2B associated with long-term potentiation
4) Confidence 0.53 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.44
Thus, there is such a possibility, although remains to be demosntrated, that inhibition of NR2B-NMDARs affect the charge transfer during LTP induction.
Negative_regulation (inhibition) of NR2B-NMDARs associated with long-term potentiation
5) Confidence 0.53 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.05 Pain Relevance 0.53
Presumably, the loss of NR2B subunits would prevent the remaining NR1 subunits from forming functional receptors in much the same way as siRNA to NR2B was found to suppress nociceptive behaviors by selectively reducing the amount of NR2B protein [27].
Negative_regulation (loss) of NR2B associated with nociception
6) Confidence 0.47 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.49 Pain Relevance 0.71
The suppression of NR2B following peripheral inflammation could have significant effects on nociception and the choice of treatments for chronic pain.
Negative_regulation (suppression) of NR2B associated with nociception, inflammation and lasting pain
7) Confidence 0.47 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.87 Pain Relevance 0.49
Only as the number of NR2B subunits is reduced do the synapses return toward normal function.
Negative_regulation (number) of NR2B in synapses
8) Confidence 0.47 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.53 Pain Relevance 0.75
The loss of NR2B subunits in the spinal cord as the nociceptive stimulus progresses suggests that pharmacological agents targeting NR2B may be less effective in chronic pain than in acute pain.
Negative_regulation (loss) of NR2B in spinal cord associated with nociception, acute pain, lasting pain and spinal cord
9) Confidence 0.47 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 1.05 Pain Relevance 0.82
A previous study in our laboratory showed that intra-CA1 blockade of NR2B-NMDARs with Ro25-6981 (5.0 ?
Negative_regulation (blockade) of NR2B-NMDARs
10) Confidence 0.46 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.27 Pain Relevance 0.19
However, the rats with intra-CA1 blockade of NR2B- and NR2A-NMDARs showed a normal auditory fear memory (Figure 6B2: F(3,24) = 0.72, p > 0.05).
Negative_regulation (blockade) of NR2B associated with anxiety disorder
11) Confidence 0.46 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.63 Pain Relevance 0.03
M doses of Ro25-6981 to block NR2B-NMDARs.
Negative_regulation (block) of NR2B-NMDARs
12) Confidence 0.46 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.06 Pain Relevance 0.24
Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit.
Negative_regulation (inhibition) of NR2B in spinal associated with neuropeptide
13) Confidence 0.45 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 18477704 Disease Relevance 0.08 Pain Relevance 0.28
LTP experiments were therefore carried out in normal solution in the presence of either NR2A or NR2B inhibitors.
Negative_regulation (inhibitors) of NR2B associated with long-term potentiation
14) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.31 Pain Relevance 0.44
The BAPTA injection decreased significantly the mean integrated optical density of phosphorylated NR1 subunit in the superficial laminae and neck region, and the phosphorylated NR2B subunit in the superficial laminae.
Negative_regulation (decreased) of NR2B in neck
15) Confidence 0.43 Published 2010 Journal Acta Histochem. Section Abstract Doc Link 19056106 Disease Relevance 0 Pain Relevance 0.55
Thus, the NMDA receptors may still remain functional as the NR2B protein decreases.
Negative_regulation (decreases) of NR2B protein associated with nmda receptor
16) Confidence 0.40 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.88 Pain Relevance 0.68
Furthermore, recent work by Tan and colleagues [27] demonstrated that selective knockdown of NR2B in the dorsal horn using siRNA can suppress formalin induced nocifensive behaviors.
Negative_regulation (knockdown) of NR2B in dorsal horn associated with dorsal horn
17) Confidence 0.39 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.86 Pain Relevance 0.55
Pharmacological blockade of NR2B-NMDARs in the lateral amygdala or in the ACC impairs formation of fear memory [23,24].
Negative_regulation (blockade) of NR2B-NMDARs in amygdala associated with anxiety disorder and amygdala
18) Confidence 0.39 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.60 Pain Relevance 0.51
Then, we examined the effects of intra-CA1 inhibition of NR2B- as well as NR2A-NMDARs on memory retrieval for the five CS-US pairing conditioning.
Negative_regulation (inhibition) of NR2B
19) Confidence 0.39 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.29 Pain Relevance 0
Inhibition of NR2B-NMDARs did not affect the late phase LTP induced by four-train HFS.
Negative_regulation (Inhibition) of NR2B-NMDARs associated with long-term potentiation
20) Confidence 0.39 Published 2008 Journal Mol Brain Section Abstract Doc Link PMC2570668 Disease Relevance 0.07 Pain Relevance 0.62

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