INT93035

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2000
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.29
Pain Relevance 4.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
cingulate cortex 4
prefrontal 3
spinal cord 2
hippocampus 2
striatum 1
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 22 100.00 Very High Very High Very High
cerebral cortex 3 99.68 Very High Very High Very High
Thalamus 3 99.00 Very High Very High Very High
Spinal cord 3 98.32 Very High Very High Very High
Hippocampus 6 97.96 Very High Very High Very High
butorphanol 9 97.36 Very High Very High Very High
Morphine 24 97.08 Very High Very High Very High
allodynia 1 96.72 Very High Very High Very High
withdrawal 6 96.36 Very High Very High Very High
amygdala 10 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 3 96.88 Very High Very High Very High
Neuropathic Pain 5 96.72 Very High Very High Very High
Anxiety Disorder 6 95.92 Very High Very High Very High
Depression 4 92.60 High High
Nociception 1 88.24 High High
Sleep Disorders 2 80.92 Quite High
Sprains And Strains 6 78.12 Quite High
Frailty 1 75.00 Quite High
Pain 2 60.56 Quite High
Alcohol Addiction 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, repeated dosing with MTEP (2 mg/kg i.p.) caused significant reductions in expression of the mRNA encoding the NR1 subunit of the N-methyl-D-aspartate receptor and the GluR2 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor in the cingulate cortex.
Negative_regulation (reductions) of Transcription (expression) of N-methyl-D-aspartate receptor in cingulate cortex associated with nmda receptor
1) Confidence 0.41 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014750 Disease Relevance 0.77 Pain Relevance 0.53
In the genetic section, the mRNA expression of NMDA receptor subunits (NR1 and NR2A) was measured in certain areas of the male rat brain (striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala).
Negative_regulation (measured) of Transcription (expression) of NR1 in prefrontal associated with nmda receptor, hippocampus and amygdala
2) Confidence 0.39 Published 2008 Journal Pharmacology Section Abstract Doc Link 18391508 Disease Relevance 0 Pain Relevance 0.64
The level of NR1 mRNA was significantly decreased in the cerebral cortex, thalamus, and CA1 area of hippocampus in butorphanol tolerant and withdrawal (7 h after stopping the infusion) rats.
Negative_regulation (decreased) of Transcription (level) of NR1 in hippocampus associated with butorphanol, hippocampus, thalamus, withdrawal and cerebral cortex
3) Confidence 0.36 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.37
Finally, repeated dosing with MTEP (2 mg/kg i.p.) caused significant reductions in expression of the mRNA encoding the NR1 subunit of the N-methyl-D-aspartate receptor and the GluR2 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor in the cingulate cortex.
Negative_regulation (reductions) of Transcription (expression) of NR1 in cingulate cortex associated with nmda receptor
4) Confidence 0.36 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014750 Disease Relevance 0.77 Pain Relevance 0.52
Real time RT-PCR was employed to determine the relative mRNA levels of NMDAR subunits, ppD and PKCgamma in the dorsal spinal cord 1, 14 and 28 days after injury.
Spec (determine) Negative_regulation (determine) of Spec (determine) Transcription (levels) of NMDAR in spinal cord associated with injury and spinal cord
5) Confidence 0.16 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18835424 Disease Relevance 0.75 Pain Relevance 0.68
In the genetic section, the mRNA expression of NMDA receptor subunits (NR1 and NR2A) was measured in certain areas of the male rat brain (striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala).
Negative_regulation (measured) of in striatum Transcription (expression) of NR1 in prefrontal associated with nmda receptor, hippocampus and amygdala
6) Confidence 0.13 Published 2008 Journal Pharmacology Section Abstract Doc Link 18391508 Disease Relevance 0 Pain Relevance 0.64

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox