INT93036

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 7.10
Pain Relevance 10.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
cleavage 1
forebrain 1
motoneuron 1
hippocampus 1
Grin2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 124 100.00 Very High Very High Very High
Anterior cingulate cortex 29 99.52 Very High Very High Very High
depression 871 99.44 Very High Very High Very High
Morphine 19 99.42 Very High Very High Very High
Hippocampus 136 99.08 Very High Very High Very High
long-term potentiation 1010 98.30 Very High Very High Very High
withdrawal 7 98.20 Very High Very High Very High
butorphanol 9 97.24 Very High Very High Very High
cerebral cortex 4 97.08 Very High Very High Very High
nMDA receptor 276 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 871 99.44 Very High Very High Very High
Anxiety Disorder 239 98.96 Very High Very High Very High
Status Epilepticus 57 98.80 Very High Very High Very High
Necrosis 8 96.84 Very High Very High Very High
Cancer 8 96.48 Very High Very High Very High
Anaerobic Bacterial Infections 59 95.60 Very High Very High Very High
INFLAMMATION 40 95.04 Very High Very High Very High
Pain 8 88.44 High High
Cognitive Disorder 20 84.44 Quite High
Li-fraumeni Syndrome 52 79.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the LTD was nearly blocked by this NR2A inhibitor, amounting to 92 ± 3% (n = 10, p < 0.05) of baseline.
Negative_regulation (inhibitor) of NR2A associated with depression
1) Confidence 0.50 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.37 Pain Relevance 0.22
LTP experiments were therefore carried out in normal solution in the presence of either NR2A or NR2B inhibitors.
Negative_regulation (inhibitors) of NR2A associated with long-term potentiation
2) Confidence 0.50 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.31 Pain Relevance 0.44
In contrast, no decrease of NR2A subunit and of post-synaptic density 95 could be detected at any time following the lesion. beta Catenin and cadherin immunoreactivity pattern changed around the cell body of facial motoneuron by day 3 after axotomy, and then, tends to recover at day post-lesion 60 days.
Neg (no) Negative_regulation (decrease) of NR2A in motoneuron
3) Confidence 0.46 Published 2005 Journal Neuroscience Section Abstract Doc Link 16182453 Disease Relevance 0 Pain Relevance 0.23
We have previously shown, using radioligand binding studies, that N-methyl-d-aspartate (NMDA) NR1 and NR2A receptor subunits density was decreased in the forebrain of morphine-dependent rats.
Negative_regulation (decreased) of NR2A in forebrain associated with morphine
4) Confidence 0.41 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17321516 Disease Relevance 0.12 Pain Relevance 0.63
The NR2A mRNA was significantly decreased in the CA1 and CA3 of hippocampus in tolerant rats and increased in the cerebral cortex and dentate gyrus in butorphanol withdrawal rats.
Negative_regulation (decreased) of NR2A in hippocampus associated with butorphanol, hippocampus, withdrawal and cerebral cortex
5) Confidence 0.40 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.52
Formalin treatment did not affect NR1 splice variant expression but significantly increased and decreased the proportion of NR2A and NR2C, respectively.
Neg (not) Negative_regulation (decreased) of NR2A
6) Confidence 0.39 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373534 Disease Relevance 0.08 Pain Relevance 0.40
Regarding the NR2 subunit expression in controls, NR2B exhibited the highest expression, followed by decreasing proportions of NR2C, NR2A, and NR2D.
Negative_regulation (decreasing) of NR2A
7) Confidence 0.39 Published 2002 Journal Amino Acids Section Abstract Doc Link 12373534 Disease Relevance 0.09 Pain Relevance 0.41
In similar experiments, either NR2A or NR2B inhibitor, i.e.
Negative_regulation (inhibitor) of NR2A
8) Confidence 0.37 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.36 Pain Relevance 0.30
Moreover, this data also indicate that targeted inhibition of the NMDA receptor NR2 subunit is a potentially important new treatment approach for inflammatory pain originating in the orofacial area.


Negative_regulation (inhibition) of NR2
9) Confidence 0.37 Published 2010 Journal J Orofac Pain Section Body Doc Link 20401359 Disease Relevance 0 Pain Relevance 0
In the present case we studied depotentiation induced by application of NMDA and examined its sensitivity to NR2A and NR2B inhibitors, since not much attention has been paid to this issue previously.
Spec (examined) Negative_regulation (inhibitors) of NR2A
10) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.28 Pain Relevance 0.24
For instance, LTD recorded in cells in ACC, was blocked by either NR2A or NR2B inhibitors suggesting involvement of both receptor types.
Negative_regulation (inhibitors) of NR2A associated with depression and anterior cingulate cortex
11) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.42 Pain Relevance 0.31
According to the proposed scenario, blockade of NR2A-type receptors would then lead to unmasking of the LTD.
Negative_regulation (blockade) of NR2A-type associated with depression
12) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.73 Pain Relevance 0.64
Then, we examined the effects of intra-CA1 inhibition of NR2B- as well as NR2A-NMDARs on memory retrieval for the five CS-US pairing conditioning.
Negative_regulation (inhibition) of NR2A-NMDARs
13) Confidence 0.36 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.29 Pain Relevance 0
We also investigated the effect of intra-CA1 blockade of NR2A-NMDARs, using the relatively selective NR2A-NMDAR antagonist NVP-AAM077.
Spec (investigated) Negative_regulation (blockade) of NR2A-NMDARs associated with antagonist
14) Confidence 0.35 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.33 Pain Relevance 0.17
l vehicle) for pharmacological blockade of NR2A-NMDARs in the CA1 region.
Negative_regulation (blockade) of NR2A-NMDARs
15) Confidence 0.35 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.20 Pain Relevance 0.21
Bath application of the NR2A relatively selective antagonist NVP-AAM077 (0.3 ?
Negative_regulation (antagonist) of NR2A associated with antagonist
16) Confidence 0.35 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.51
The real-time polymerase chain reaction results showed that prenatal morphine exposure caused significant decreases in mRNA levels of the PSD-95 and three NMDAR subunits (NR1, NR2A, and NR2B) in offspring (P14 and P45).
Negative_regulation (decreases) of NR2A associated with morphine
17) Confidence 0.35 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.16 Pain Relevance 0.66
However, the rats with intra-CA1 blockade of NR2B- and NR2A-NMDARs showed a normal auditory fear memory (Figure 6B2: F(3,24) = 0.72, p > 0.05).
Negative_regulation (blockade) of NR2A-NMDARs associated with anxiety disorder
18) Confidence 0.31 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.63 Pain Relevance 0.03
NVP-AAM077 (0.4 µM) has been shown to completely block NR2A-containing NMDAR and attenuate NR2B-containing NMDAR [23], [24].
Negative_regulation (block) of NR2A-containing
19) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.87 Pain Relevance 1.04
The gene expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2C was up-regulated (+3.78), while the NR2A subunit was down-regulated (?
Negative_regulation (down-regulated) of NR2A
20) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.24 Pain Relevance 0.11

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