INT93037

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 26
Total Number 30
Disease Relevance 11.90
Pain Relevance 16.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal cord 4
hippocampus 2
neuronal 1
spinal 1
neurons 1
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 490 100.00 Very High Very High Very High
Spinal cord 240 99.98 Very High Very High Very High
Hippocampus 106 99.96 Very High Very High Very High
tetrodotoxin 5 99.84 Very High Very High Very High
Pain 80 99.44 Very High Very High Very High
intrathecal 63 99.44 Very High Very High Very High
antagonist 99 99.40 Very High Very High Very High
butorphanol 9 99.12 Very High Very High Very High
long-term potentiation 392 99.04 Very High Very High Very High
Glutamate 93 99.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 158 99.64 Very High Very High Very High
Pain 128 99.44 Very High Very High Very High
Injury 103 99.34 Very High Very High Very High
Diabetes Mellitus 87 99.00 Very High Very High Very High
INFLAMMATION 129 98.68 Very High Very High Very High
Hyperalgesia 130 97.20 Very High Very High Very High
Neuropathic Pain 125 95.88 Very High Very High Very High
Dementia 1 95.44 Very High Very High Very High
Nervous System Injury 15 95.28 Very High Very High Very High
Dyskinesias 1 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The efficacy of intrathecal NR2B antagonists in acute models and the lack of effect in chronic injury models support the concept that NR2B is down regulated in the spinal cord as the injury progresses.
Regulation (regulated) of NR2B in spinal cord associated with antagonist, injury, spinal cord and intrathecal
1) Confidence 0.57 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 1.26 Pain Relevance 0.97
These data will hopefully provide the impetus for development of novel compounds that use multiple approaches to modulate the activity of NR2B subunit-containing NMDA receptors, thus bringing to fruition the promise of therapeutic efficacy utilizing this approach.
Regulation (modulate) of NR2B associated with nmda receptor
2) Confidence 0.52 Published 2006 Journal Curr Opin Pharmacol Section Abstract Doc Link 16376149 Disease Relevance 0.61 Pain Relevance 0.72
Continuous intracerebroventricular (i.c.v.) infusion with butorphanol (26 nmol/microl/h) resulted in significant modulations in the NRI, NR2A, and NR2B mRNA levels.
Regulation (modulations) of NR2B associated with butorphanol and intracerebroventricular
3) Confidence 0.45 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.31
This could be prevented by intrathecal administration of inhibitors of the signaling kinases Src and PKC and of group I metabotropic glutamate and NK1 receptors, revealing that in this model NR2B could be modulated by glutamatergic and tachykinin nociceptive transmission, leading to hyperalgesia.
Regulation (modulated) of NR2B associated with nociception, hyperalgesia, glutamate and intrathecal
4) Confidence 0.45 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.34 Pain Relevance 0.57
M did not affect NR2B-NMDAR currents in vitro [22].
Neg (not) Regulation (affect) of NR2B-NMDAR
5) Confidence 0.41 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.23
g) treatment potentiated the antinociceptive effect of morphine, with a 5.5-fold leftward shift of the morphine dose-response curve in morphine-tolerant rats, and this was associated with reversal of the up-regulated NR1 and NR2B subunits in the synaptosome fraction.
Regulation (regulated) of NR2B
6) Confidence 0.38 Published 2010 Journal Anesthesiology Section Body Doc Link 20938337 Disease Relevance 0 Pain Relevance 0
We found that the upregulated phosphorylation of both NR1 and NR2B subunits induced by capsaicin injection was significantly potentiated by the PP2A inhibitor without affecting the NR1 and NR2B protein itself.
Neg (without) Regulation (affecting) of NR2B in PP2A associated with qutenza
7) Confidence 0.38 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15919130 Disease Relevance 0 Pain Relevance 0.83
PP2 alone did not alter NR2B basal phosphorylation levels (data not shown).
Neg (not) Regulation (alter) of NR2B
8) Confidence 0.33 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.11 Pain Relevance 0.17
As shown in Figure 10A–D, both leupeptin (100 µM) and calpeptin (100 µM) completely prevented UCB-induced down-regulation of NR2A and NR2B subunit proteins.
Regulation (regulation) of NR2B
9) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.07 Pain Relevance 0.07
However, NR2B was up-regulated by tetrodotoxin (Audinat et al., 1994), suggesting a contribution of spontaneous electrical activity to block the fast Na+ current in the neuronal cells.
Regulation (regulated) of NR2B in neuronal associated with tetrodotoxin
10) Confidence 0.29 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.22 Pain Relevance 0.48
Recent studies demonstrated that accumulation of glutaric acid (GA), analogue of glutamate, in the glutaric aciduria type I (MIM 231670) and chronic stimulation of NMDA simultaneously down-regulate the NR2B subunit and decreases Na+/K+-ATPase activity (Resink et al., 1996; Kölker et al., 2002).
Regulation (regulate) of NR2B associated with glutamate
11) Confidence 0.29 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.24 Pain Relevance 0.48
Chronic incubation with GA resulted in a down-regulation particularly of the NR2B subunit and reduced the NMDA receptor-mediated increase in intracellular Ca2+ (Kölker et al., 2002).
Regulation (regulation) of NR2B associated with nmda receptor
12) Confidence 0.29 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.28 Pain Relevance 0.39
Here we used a selective NR2B antagonist (Ro-256981) to determine the contribution of NR2B-containing NMDA receptors to pain-related sensitization of CeA neurons.
Spec (determine) Regulation (contribution) of NR2B-containing in neurons associated with pain, nmda receptor, antagonist and amygdala
13) Confidence 0.27 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2679723 Disease Relevance 0.47 Pain Relevance 0.89
In the hippocampus, immunoreactivity for NR2A and NR2B subunits are reduced in diabetic rats.
Regulation (immunoreactivity) of NR2B in hippocampus associated with diabetes mellitus and hippocampus
14) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.98 Pain Relevance 0.40
Therefore, we investigated the hypothesis that a humoral autoimmune response targeting the NR2B subunit of NMDA receptor relieves pain like behaviours produced by peripheral injury.
Regulation (targeting) of NR2B associated with pain, nmda receptor and injury
15) Confidence 0.27 Published 2007 Journal Chin. Med. J. Section Abstract Doc Link 17517177 Disease Relevance 0.36 Pain Relevance 0.36
The results indicate that the use of siRNA targeting the NR2B subunit not only decreased the expression of NR2B mRNA and its associated protein, as demonstrated by real-time PCR and Western blotting, but also abolished formalin-induced pain behaviors in rat model.
Regulation (targeting) of NR2B associated with pain
16) Confidence 0.27 Published 2005 Journal Gene Ther. Section Abstract Doc Link 15470478 Disease Relevance 0.34 Pain Relevance 0.62
According to the quantitative changes of NMDA receptor subunits, including NR1, NR2A, and NR2B, induced by diverse types of reinforcers, we chose NR2B subunit as the target of research.
Regulation (changes) of NR2B associated with nmda receptor
17) Confidence 0.26 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16631172 Disease Relevance 0.17 Pain Relevance 0.66
The loss of NR2B subunits in the spinal cord as the nociceptive stimulus progresses suggests that pharmacological agents targeting NR2B may be less effective in chronic pain than in acute pain.
Regulation (targeting) of NR2B in spinal cord associated with nociception, acute pain, lasting pain and spinal cord
18) Confidence 0.25 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 1.03 Pain Relevance 0.83
There seems a recruitment mechanism in the hippocampus and amygdala for involvement of NR2B-NMDARs in memory acquisition: the heavier the training load is, the more involved the NR2B-NMDAR is.


Regulation (involved) of NR2B-NMDAR in amygdala associated with hippocampus and amygdala
19) Confidence 0.24 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.28 Pain Relevance 0.44
It is possible that NR2B-NMDARs are more sensitive to the certain form of LTP induction protocol.
Spec (possible) Regulation (sensitive) of NR2B-NMDARs associated with long-term potentiation
20) Confidence 0.24 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.06 Pain Relevance 0.53

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