INT9304

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Context Info
Confidence 0.39
First Reported 1980
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 70
Total Number 71
Disease Relevance 51.97
Pain Relevance 64.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
neurons 6
PAG 5
PAG 5
output neurons 3
LRF 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 331 100.00 Very High Very High Very High
Periaqueductal grey 190 100.00 Very High Very High Very High
GABAergic 94 100.00 Very High Very High Very High
gABA 70 100.00 Very High Very High Very High
Enkephalin 50 100.00 Very High Very High Very High
midbrain 47 100.00 Very High Very High Very High
Spinal cord 40 100.00 Very High Very High Very High
Glutamate 39 100.00 Very High Very High Very High
Antinociceptive 37 100.00 Very High Very High Very High
opiate 33 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 581 100.00 Very High Very High Very High
Diabetic Neuropathy 6 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 100.00 Very High Very High Very High
Pain 82 99.64 Very High Very High Very High
Targeted Disruption 18 99.56 Very High Very High Very High
Bradycardia 8 99.40 Very High Very High Very High
Diabetes Mellitus 20 99.08 Very High Very High Very High
Injury 23 98.92 Very High Very High Very High
Hemorrhage 10 98.84 Very High Very High Very High
Generalized Anxiety Disorder 40 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the PAG-spinal cord pathway by analgesics such as opioids and cannabinoids is thought to be mediated by a reduction in the GABAergic inhibition of PAG and rostral ventromedial medulla output neurons, a process known as disinhibition.
Negative_regulation (inhibition) of PAG in output neurons associated with gabaergic, cannabinoid, analgesic, periaqueductal grey, opioid, rostral ventromedial medulla and spinal cord
1) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.58 Pain Relevance 1.60
In contrast, inactivation of the dorsolateral PAG with lidocaine was ineffective.
Negative_regulation (inactivation) of PAG associated with urological neuroanatomy and lidocaine
2) Confidence 0.37 Published 2001 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 11506988 Disease Relevance 1.02 Pain Relevance 0.64
Neuronal activity in the vlPAG was inhibited with either lidocaine or cobalt chloride 5 min before hemorrhage (2.5 ml/100 g body wt) was initiated in conscious, unrestrained rats.
Negative_regulation (inhibited) of vlPAG in body associated with cva and lidocaine
3) Confidence 0.37 Published 2001 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 11506988 Disease Relevance 1.00 Pain Relevance 0.57
We showed previously that (1 microgram) tetracaine block of PAG prevents the analgesic effect of PGC-ME injections, and also produces hyperalgesia regarding baseline tail-flick latencies.
Negative_regulation (block) of PAG in tail associated with hyperalgesia, analgesic, tail-flick, urological neuroanatomy and enkephalin
4) Confidence 0.36 Published 1994 Journal Int. J. Neurosci. Section Abstract Doc Link 7928102 Disease Relevance 0.48 Pain Relevance 1.18
The PAG inhibition of baroreflexes was greatly attenuated following electrolytic as well as chemical destruction of the parabrachial region.
Negative_regulation (inhibition) of PAG in PAG associated with periaqueductal grey and parabrachial
5) Confidence 0.35 Published 1993 Journal Pflugers Arch. Section Abstract Doc Link 8414916 Disease Relevance 1.36 Pain Relevance 0.59
PAG inhibition of baroreflex vagal bradycardia was not affected following spinal cord transection at C1, indicating that the inhibition was exclusively central in origin and not due to peripheral, prejunctional inhibition of vagal acetylcholine release by increased cardiac sympathetic nerve activities.
Negative_regulation (inhibition) of PAG in PAG associated with periaqueductal grey, bradycardia and spinal cord
6) Confidence 0.35 Published 1993 Journal Pflugers Arch. Section Abstract Doc Link 8414916 Disease Relevance 1.57 Pain Relevance 0.60
Mere confrontation with a non-aggressive opponent failed to induce analgesia and was associated in C57BL/6 mice with a significant reduction in the beta-ELIR content of both the pituitary and the PAG.
Negative_regulation (reduction) of PAG in Mere associated with periaqueductal grey and analgesia
7) Confidence 0.33 Published 1988 Journal Brain Res. Section Abstract Doc Link 3401713 Disease Relevance 0.88 Pain Relevance 0.80
Following dopamine depletion of the PAG, large neurons (not small ones) were selectively affected by the toxin (61.9% dopamine cell loss, 80.7% reduction of in vitro dopaminergic peak), and opiate-induced analgesia in the hot-plate test (not the tail-immersion test) was reliably attenuated in lesioned rats (P < 0.01).
Negative_regulation (depletion) of PAG in tail associated with dopamine, periaqueductal grey, opiate and analgesia
8) Confidence 0.32 Published 2004 Journal Pain Section Abstract Doc Link 15275769 Disease Relevance 1.16 Pain Relevance 1.54
OFQ/N(1-17) attenuation of antinociception produced by a neuroexcitant indicates that OFQ/N(1-17) reverses opioid antinociception by inhibiting PAG output neurons.
Negative_regulation (inhibiting) of PAG in output neurons associated with antinociception, central grey and opioid
9) Confidence 0.32 Published 1997 Journal Neuroreport Section Abstract Doc Link 9427301 Disease Relevance 0.59 Pain Relevance 1.24
However, a high dose (5 mg/kg, s.c.) of naloxone significantly and equally attenuated PAG SPA in both naive and diabetic rats.
Negative_regulation (attenuated) of PAG in PAG associated with diabetes mellitus, narcan, urological neuroanatomy and analgesia
10) Confidence 0.32 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1407710 Disease Relevance 1.48 Pain Relevance 1.23
The glycine level in PAG can be decreased and the pain suppressed by administering paracetamol.
Negative_regulation (decreased) of PAG in PAG associated with pain, paracetamol and urological neuroanatomy
11) Confidence 0.31 Published 2009 Journal Electrophoresis Section Abstract Doc Link 19757436 Disease Relevance 0.60 Pain Relevance 0.35
Chronic morphine (3 days) decreased the low Km GTPase activity of PAG (42), whereas it increased the one of thalamus (99).
Negative_regulation (decreased) of PAG in thalamus associated with urological neuroanatomy, thalamus and morphine
12) Confidence 0.30 Published 1993 Journal Life Sci. Section Abstract Doc Link 8464330 Disease Relevance 0.46 Pain Relevance 0.74
The mechanism whereby systemic methysergide reduces PAG spinal inhibition is unknown and cannot necessarily be related to a blockade of spinally released 5-hydroxytryptamine.
Negative_regulation (inhibition) of PAG in spinal associated with periaqueductal grey
13) Confidence 0.30 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 4076338 Disease Relevance 0.41 Pain Relevance 0.45
Both kinds of inhibition may be blocked by naloxone, this suggests that endogenous opiate like substances involved in these inhibitory processes caused by stimulating role in the inhibitory effect of PAG.
Negative_regulation (effect) of PAG associated with narcan, opiate and central grey
14) Confidence 0.30 Published 1991 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 1873895 Disease Relevance 0.73 Pain Relevance 0.62
Here we report that opioid inhibition of GABAergic synaptic currents in the PAG is controlled by a presynaptic voltage-dependent potassium conductance.
Negative_regulation (inhibition) of PAG associated with periaqueductal grey, gabaergic and opioid
15) Confidence 0.27 Published 1997 Journal Nature Section Abstract Doc Link 9403690 Disease Relevance 0.43 Pain Relevance 1.57
These mechanisms account for the analgesic action of cyclooxygenase inhibitors in the PAG and their synergism with opioids.
Negative_regulation (inhibitors) of PAG associated with periaqueductal grey, analgesic and opioid
16) Confidence 0.27 Published 1997 Journal Nature Section Abstract Doc Link 9403690 Disease Relevance 0.40 Pain Relevance 1.37
When the perfusion medium was modified by substitution of magnesium for calcium, extracellular HA levels in the PAG decreased by a maximum of 72%, and morphine-induced HA release was prevented.
Negative_regulation (decreased) of PAG associated with central grey and morphine
17) Confidence 0.27 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 7515945 Disease Relevance 0.58 Pain Relevance 1.04
Systemically administered naloxone (1-10 mg/kg i.v.) reduced (greater than 20% below predrug inhibition) inhibition from PAG and/or LRF in 5/12 units and had no effect in the remainder.
Negative_regulation (inhibition) of PAG in LRF associated with narcan and central grey
18) Confidence 0.27 Published 1990 Journal Brain Res. Section Abstract Doc Link 2224516 Disease Relevance 0.74 Pain Relevance 0.91
Systemic methysergide (2-6 mg/kg i.v.) selectively reduced PAG-evoked inhibition in 6 units, while inhibitions from both PAG and LRF stimulation were reduced in one unit and unaffected in 8 units.
Negative_regulation (inhibitions) of PAG in LRF associated with central grey
19) Confidence 0.27 Published 1990 Journal Brain Res. Section Abstract Doc Link 2224516 Disease Relevance 0.77 Pain Relevance 0.97
Descending inhibition from PAG is considered as a possible mechanism for analgesia produced by stimulation of PAG and other brainstem structures.
Negative_regulation (inhibition) of PAG in brainstem associated with medulla, central grey and analgesia
20) Confidence 0.27 Published 1980 Journal Exp Brain Res Section Abstract Doc Link 7363975 Disease Relevance 0.67 Pain Relevance 0.62

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