INT93045

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 25.26
Pain Relevance 9.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
T-cell 6
Th2 cells 4
lymphocytes 2
lungs 2
heart 2
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1063 100.00 Very High Very High Very High
cytokine 993 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
Inflammatory response 68 99.96 Very High Very High Very High
chemokine 192 99.64 Very High Very High Very High
narcan 7 99.62 Very High Very High Very High
agonist 156 99.60 Very High Very High Very High
antagonist 328 99.08 Very High Very High Very High
Neuritis 9 98.24 Very High Very High Very High
tolerance 15 94.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1114 100.00 Very High Very High Very High
Eosinophilia 140 100.00 Very High Very High Very High
Burns 63 99.80 Very High Very High Very High
Asthma 2350 99.60 Very High Very High Very High
Fungal Infection 7 99.56 Very High Very High Very High
Helminth Infection 25 99.52 Very High Very High Very High
Targeted Disruption 143 99.44 Very High Very High Very High
Organ Transplantation 6 99.38 Very High Very High Very High
Disease 188 99.36 Very High Very High Very High
Atherosclerosis 136 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice.
Negative_regulation (inhibits) of Gene_expression (expression) of Th2 associated with cytokine
1) Confidence 0.43 Published 2004 Journal Blood Section Title Doc Link 14604971 Disease Relevance 0.94 Pain Relevance 0.42
Inhalation of APC significantly inhibited the expression of T helper 2 (Th2) cytokines, immunoglobulin E (IgE), eosinophilic inflammation, and hyperresponsiveness.
Negative_regulation (inhibited) of Gene_expression (expression) of Th2 associated with rhinitis, inflammation and cytokine
2) Confidence 0.36 Published 2004 Journal Blood Section Abstract Doc Link 14604971 Disease Relevance 0.99 Pain Relevance 0.45
APC also significantly suppressed the expression of Th2 cytokines and IgE from lymphocytes isolated from OVA-sensitized/challenged animals.
Negative_regulation (suppressed) of Gene_expression (expression) of Th2 in lymphocytes associated with cytokine
3) Confidence 0.31 Published 2004 Journal Blood Section Abstract Doc Link 14604971 Disease Relevance 0.95 Pain Relevance 0.48
agonists have the potential to shift the T-cell response from Th2 to Th1, or to reduce Th2 cytokine expression, which may be of therapeutic benefit in ASD.
Negative_regulation (reduce) of Gene_expression (expression) of Th2 in T-cell associated with agonist and cytokine
4) Confidence 0.31 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.37 Pain Relevance 0.33
Th2 cytokine levels in the BAL fluid of C57BL/6 mice were inhibited in comparison with Balb/c mice following sensitization and challenge with Af
Negative_regulation (inhibited) of Gene_expression (levels) of Th2 associated with aspergillus infection and cytokine
5) Confidence 0.29 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.81 Pain Relevance 0.23
These results indicate that naloxone increases Th1 and decreases Th2 cytokine production.
Negative_regulation (decreases) of Gene_expression (production) of Th2 associated with narcan and cytokine
6) Confidence 0.27 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268404 Disease Relevance 0.09 Pain Relevance 0.84
To determine whether the cytokine response in the heart after burn was also related to changes in the Th1 and Th2 we analyzed heart tissue for IFN-?
Spec (whether) Negative_regulation (related) of Gene_expression (changes) of Th2 in heart associated with burns and cytokine
7) Confidence 0.25 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.88 Pain Relevance 0.21
agonists have been shown to inhibit GATA-3 expression and Th2-driven inflammatory responses in murine models [77].
Negative_regulation (inhibit) of Gene_expression (expression) of Th2-driven associated with inflammatory response and agonist
8) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.75 Pain Relevance 0.31
Mice with deficient TH2 cytokine expression, induced by gene deletion or the usage of TH2 cytokine antagonists, showed diminished AHR and eosinophilic inflammation [9, 11].
Negative_regulation (deficient) of Gene_expression (expression) of TH2 associated with rhinitis, inflammation, antagonist and cytokine
9) Confidence 0.24 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.50 Pain Relevance 0.29
IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis.
Negative_regulation (inhibits) of Gene_expression (production) of Th2 associated with experimental autoimmune neuritis, neuritis and cytokine
10) Confidence 0.22 Published 2007 Journal J. Neuroimmunol. Section Title Doc Link 17218016 Disease Relevance 0.37 Pain Relevance 0.49
The combination FPS treatment decreased Th2 infiltration compared with Sal indicating that steroids and ?
Negative_regulation (decreased) of Gene_expression (infiltration) of Th2
11) Confidence 0.21 Published 2006 Journal Virol J Section Body Doc Link PMC1488829 Disease Relevance 1.34 Pain Relevance 0.17
The combination FPS treatment decreased Th2 infiltration compared with Sal indicating that steroids and ?
Negative_regulation (compared) of Gene_expression (infiltration) of Th2
12) Confidence 0.21 Published 2006 Journal Virol J Section Body Doc Link PMC1488829 Disease Relevance 1.34 Pain Relevance 0.17
Consequently, a broader approach to inhibiting Th2 cytokine production, as possible with H4R antagonists and other small molecule inhibitors of Th2 cell polarization, may prove beneficial.
Negative_regulation (inhibiting) of Gene_expression (production) of Th2 in Th2 cell associated with antagonist and cytokine
13) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.45 Pain Relevance 0.34
While that study demonstrated a reduction in Th2 cytokine production, no changes in disease relevant Th2 driven pathologies were reported.
Negative_regulation (reduction) of Gene_expression (production) of Th2 associated with disease and cytokine
14) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.84 Pain Relevance 0.31
Notably, a profound reduction in Th2 polarization and the production of the effector Th2 cytokine, IL-13, was observed [6].
Negative_regulation (reduction) of Gene_expression (production) of Th2 associated with cytokine
15) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 1.03 Pain Relevance 0.21
This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN.
Negative_regulation (inhibits) of Gene_expression (production) of Th2 associated with neuritis and cytokine
16) Confidence 0.19 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17218016 Disease Relevance 0.42 Pain Relevance 0.43
In BALF, the levels of a Th2 cytokines, including IL-4, IL-5, and IL-13 were significantly decreased in the sTNFR treated group compared with the OVA group (96.01 ± 16.08 vs. 50.67 ± 7.79*, 223.6 ± 40.3 vs. 136.6 ± 21.7*, 203.3 ± 20.1 vs. 116.6 ± 15.5**, respectively ; *p < 0.05, **p < 0.01) (Figs. 2A, B and C).
Negative_regulation (decreased) of Gene_expression (levels) of Th2 associated with cytokine
17) Confidence 0.18 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.18 Pain Relevance 0.16
Reduced TH2 responses in the MLNs had no influence on systemic type 2 antibody responses, as there were similar total serum IgG1 (unpublished data) and IgE (Figure 2) concentrations in infected SM-MHCCreIL-4R??
Negative_regulation (Reduced) of Gene_expression (responses) of TH2
18) Confidence 0.18 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.15 Pain Relevance 0.14
gene-expressing plasmids or transferred by an adenovirus vector [30-32] can prevent and reverse established allergen-induced airway hyper-reactivity, airway eosinophilia and Th2 cytokine production.
Negative_regulation (prevent) of Gene_expression (production) of Th2 associated with eosinophilia and cytokine
19) Confidence 0.17 Published 2009 Journal Respir Res Section Body Doc Link PMC2713210 Disease Relevance 0.99 Pain Relevance 0.22
gene-expressing plasmids or transferred by an adenovirus vector [30-32] can prevent and reverse established allergen-induced airway hyper-reactivity, airway eosinophilia and Th2 cytokine production.
Negative_regulation (reverse) of Gene_expression (production) of Th2 associated with eosinophilia and cytokine
20) Confidence 0.17 Published 2009 Journal Respir Res Section Body Doc Link PMC2713210 Disease Relevance 0.98 Pain Relevance 0.22

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