INT93046

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 24.54
Pain Relevance 7.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
lung 8
T cell 8
regulatory T cells 4
macrophage 2
CD86 2
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1249 100.00 Very High Very High Very High
Inflammation 1090 100.00 Very High Very High Very High
agonist 177 99.98 Very High Very High Very High
Opioid 2 98.48 Very High Very High Very High
antagonist 301 98.12 Very High Very High Very High
Endocannabinoid 16 97.56 Very High Very High Very High
Multiple sclerosis 79 97.48 Very High Very High Very High
Inflammatory response 88 96.96 Very High Very High Very High
Central nervous system 19 91.64 High High
hyperexcitability 10 90.00 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1193 100.00 Very High Very High Very High
Asthma 2748 99.98 Very High Very High Very High
Hypersensitivity 234 99.98 Very High Very High Very High
Disease 463 99.60 Very High Very High Very High
Eosinophilia 186 99.52 Very High Very High Very High
Targeted Disruption 200 98.08 Very High Very High Very High
Multiple Sclerosis 97 97.48 Very High Very High Very High
Aspergillus Infection 88 97.16 Very High Very High Very High
Lymphadenopathy 4 96.64 Very High Very High Very High
Rhinitis 100 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, evidence suggests that endocannabinoids have immunosuppressant and anti-inflammatory properties, they downregulate the production of T helper 1 (Th1) cytokines, enhancing the production of T helper 2 (Th2) cytokines, since a polarization of T cell response towards a Th2 phenotype has been associated with therapeutic benefit in MS, while a shift towards Th1 has been associated with disease progression (Matsuda et al 1990; Hemmer 2002).
Positive_regulation (enhancing) of Gene_expression (production) of Th2 in T cell associated with endocannabinoid, multiple sclerosis, inflammation, disease progression and cytokine
1) Confidence 0.47 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 0.83 Pain Relevance 0.83
We have identified, using serial analysis of gene expression, transcripts that are overexpressed in regulatory T cells compared with Th1 and Th2 clones.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Th2 in regulatory T cells
2) Confidence 0.38 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801640 Disease Relevance 0.09 Pain Relevance 0.11
Regulatory T cells overexpress a subset of Th2 gene transcripts.
Positive_regulation (overexpress) of Gene_expression (overexpress) of Th2 in Regulatory T cells
3) Confidence 0.38 Published 2002 Journal J. Immunol. Section Title Doc Link 11801640 Disease Relevance 0.09 Pain Relevance 0.10
In support of that, recent studies in mice over expressing IL-4 [30,31], IL-5 [32] and IL-13 [33] in the lung tissue indicated that Th2-type inflammation induced over production of SP-D.
Positive_regulation (induced) of Gene_expression (inflammation) of Th2-type in lung associated with inflammation
4) Confidence 0.25 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.77 Pain Relevance 0.13
We have previously shown that allergic Th2-type inflammation induced production of SP-D, an otherwise constitutively expressed protein in the lung [12].
Positive_regulation (induced) of Gene_expression (production) of Th2-type in lung associated with inflammation and hypersensitivity
5) Confidence 0.25 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.04 Pain Relevance 0.20
ligands (troglitazone, pioglitazone, and rosiglitazone) increases the expression of the specific Th2 transcription factor, GATA-3.
Positive_regulation (increases) of Gene_expression (expression) of Th2
6) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.23 Pain Relevance 0.21
Hence, also patients suffering from allergic asthma displayed mixed T helper cell responses, reflected by the occurrence of TH2 specific IL-13 and of TH1 specific IFN-?
Positive_regulation (occurrence) of Gene_expression (specific) of TH2 associated with asthma
7) Confidence 0.24 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.65 Pain Relevance 0.12
Mice with deficient TH2 cytokine expression, induced by gene deletion or the usage of TH2 cytokine antagonists, showed diminished AHR and eosinophilic inflammation [9, 11].
Positive_regulation (induced) of Gene_expression (expression) of TH2 associated with rhinitis, inflammation, antagonist and cytokine
8) Confidence 0.19 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.50 Pain Relevance 0.29
Earlier reports proposed a Th2 response (especially IL-4) (or a mixed Th1 and Th2 response) [1, 32–35] whereas recent evidences demonstrated the importance of the Th1 response especially IFN-?
Positive_regulation (mixed) of Gene_expression (response) of Th2
9) Confidence 0.19 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.87 Pain Relevance 0.18
Earlier reports proposed a Th2 response (especially IL-4) (or a mixed Th1 and Th2 response) [1, 32–35] whereas recent evidences demonstrated the importance of the Th1 response especially IFN-?
Positive_regulation (mixed) of Gene_expression (response) of Th2
10) Confidence 0.19 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.86 Pain Relevance 0.18
Effects of Bv8 on KLH-stimulated Th1 and Th2 cytokine production in vitro and in vivo
Positive_regulation (stimulated) of Gene_expression (production) of Th2 associated with cytokine
11) Confidence 0.18 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.11 Pain Relevance 0.11
Unexpectedly, an early and strong, yet transient, induction of expression of the Th2 cytokines IL-4, IL-5 and IL-13 was measured in pulmonary T cells by day 2, before clinical manifestations became noticeable (Figure 3).
Positive_regulation (induction) of Gene_expression (expression) of Th2 in T cells associated with cytokine
12) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.50 Pain Relevance 0.21
It is important to note that there are conflicting reports on the basic notion that an imbalance in Th1/Th2 immunity is best characterized in the elderly by overactive Th1 and underactive Th2 cytokine production.
Positive_regulation (underactive) of Gene_expression (production) of Th2 associated with cytokine
13) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.56 Pain Relevance 0.34
TLR4 deficient mice have reduced CD86 expression on DCs and a reduced ability to promote Th2 cytokines and allergen-specific IgE levels [58].
Positive_regulation (promote) of Gene_expression (levels) of Th2 in CD86 associated with cytokine
14) Confidence 0.13 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.10
may induce immune deviation toward the production of Th2 cytokines, which may contribute to its therapeutic benefit in MS [27].
Spec (may) Positive_regulation (induce) of Gene_expression (production) of Th2 associated with multiple sclerosis and cytokine
15) Confidence 0.12 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.26 Pain Relevance 0.64
In addition, by itself it can stimulate TH2 cytokine production [40].
Positive_regulation (stimulate) of Gene_expression (production) of TH2 associated with cytokine
16) Confidence 0.11 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 0.68 Pain Relevance 0.33
Increased intracellular pH, modifications of Ca and Mg binding proteins, increase in 'magnesium-like' polyamines, stimulation of cellular antioxidant system; decreased activity of EAA metabotropic receptors and of opioid mu (and delta) receptors, increased activity of inhibitory neuromediators, increased production of anti-inflammatory mediator such as cytokines Th 2, stimulation of systemic antioxidant and antialdehyde defences.
Positive_regulation (increased) of Gene_expression (production) of Th 2 associated with inflammation, opioid and cytokine
17) Confidence 0.11 Published 2000 Journal Magnes Res Section Abstract Doc Link 11153899 Disease Relevance 0.86 Pain Relevance 0.81
A study done in 1992 also demonstrated increased IL-4 and IL-10 transcripts in the graft and spleen using a murine heart allograft model.[27] Similarly in randomized controlled trials comparing the effects of allogeneic blood transfusion versus autologous blood transfusion, a statistically significant increase was observed in mean levels of cytokines of the Th2 pathway (IL-10) in allogeneic transfusion arm which remain increased up to day 7 post-op.[9]
Positive_regulation (increase) of in heart Gene_expression (pathway) of Th2 in blood associated with cytokine
18) Confidence 0.09 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0 Pain Relevance 0.35
B and MAP kinases, and drives production of Th2-associated cytokines from in vitro polarized Th2 cells [295].
Positive_regulation (polarized) of Gene_expression (production) of Th2-associated in Th2 cells associated with cytokine
19) Confidence 0.09 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.21 Pain Relevance 0.12
ST2L is preferentially expressed on Th2 cells [297] and stimulates Th2 cytokine production in the lung and functions as an important effector molecule of Th2 (but not Th1) responses [298,299].
Positive_regulation (stimulates) of Gene_expression (production) of Th2 in lung associated with cytokine
20) Confidence 0.09 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.41 Pain Relevance 0.15

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